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Atractylodes macrocephala-derived extracellular vesicles-like particles enhance the recovery of ulcerative colitis by remodeling intestinal microecological balance
Publication Year: 2025 Source: J Nanobiotechnology PMID: 40490795
Current treatment of ulcerative colitis (UC) remains challenging, with the mainstay of therapy being 5-aminosalicylic acid-based drugs, which have limited and inconsistent results. Atractylodes macrocephala (AM) is a traditional Chinese medicine commonly used in the clinical treatment of various inflammatory diseases. Herein, we demonstrate that AM-derived extracellular vesicle-like particles (AMEVLP) …
The effectiveness of second- and-third-line biologics in perianal Crohn's disease-a multicenter propensity score-matched study
Publication Year: 2025 Source: J Crohns Colitis PMID: 40490896 DOI: 10.1093/ecco-jcc/jjaf099
BACKGROUND AND AIMS: Anti-tumor necrosis factor-alpha inhibitors (anti-TNFs) are the established treatment for perianal Crohn's disease (pCD), but relapse and non-response are common. Data on second- and third-line biologics are limited. We present the first direct comparison of second- and third-line biologics in pCD patients with active perianal disease previously …
ST6GAL1 promotes IBD B cell recruitment to the inflamed colon in a CD22-dependent mechanism
Publication Year: 2025 Source: J Crohns Colitis PMID: 40491026 DOI: 10.1093/ecco-jcc/jjaf097
BACKGROUND AND AIMS: Since the discovery that auto-reactive anti-alphavbeta6 integrin antibodies are associated with ulcerative colitis, cells from the B cell lineage, especially plasmablasts and plasma cells have increasingly come into the focus of research on inflammatory bowel disease. However, the mechanisms regulating their recruitment from the circulation to the …
Association between Food Diversity in the Infant Period and the Risk of Inflammatory Bowel Disease: A Nationwide Cohort Study in South Korea
Publication Year: 2025 Source: J Crohns Colitis PMID: 40491043 DOI: 10.1093/ecco-jcc/jjaf101
BACKGROUND: Emerging evidence suggests that diet plays a significant role in the development of inflammatory bowel diseases. This study aimed to assess the association between early-life food diversity and the incidence of inflammatory bowel diseases from a nationwide retrospective cohort study in South Korea. METHODS: This study incorporated 1,242,295 South …
Glutamine Attenuates Inflammation and Oxidative Stress in Ulcerative Colitis by Suppressing Wilms' Tumor 1 Associated Protein-Mediated N6-Methyladenosine Modification of Nuclear Receptor Coactivator 3
Publication Year: 2025 Source: Chem Biol Drug Des PMID: 40491173
Ulcerative colitis (UC) is a chronic inflammatory condition. Glutamine (Gln) has shown an improved effect on UC. However, its molecular determinants are incompletely understood. NCM460 cells were stimulated with lipopolysaccharide (LPS) to generate an in vitro UC cell model, and dextran sulfate sodium (DSS)-induced UC models were established in mice. …
Impact of mirikizumab treatment on fatigue in patients with moderately to severely active Crohn's disease: results from the phase 3 VIVID-1 study
Publication Year: 2025 Source: J Crohns Colitis PMID: 40491246
BACKGROUND: Fatigue is a debilitating multifactorial symptom experienced by patients with Crohn's disease (CD). Mirikizumab, an anti-interleukin-23p19 antibody, demonstrated significant efficacy and safety in the patients with moderately to severely active CD. This analysis investigated the impact of mirikizumab on fatigue and the association between changes in clinical, endoscopic, and …
The gut-heart axis: unveiling the roles of gut microbiota in cardiovascular diseases
Publication Year: 2025 Source: Front Cardiovasc Med PMID: 40491716
The gut microbiome refers to the collective genomes of the approximately 1,000-1,150 microbial species found in the human gut, called the gut microbiota. Changing the gut microbiota composition has been shown to affect cardiovascular health significantly. Numerous studies have demonstrated the part that gut microbiota and its metabolites play in …
How Do Organelle-Targeting Nanotherapeutics Treat Inflammatory Diseases? A Comprehensive Review of the Literature
Publication Year: 2025 Source: Int J Nanomedicine PMID: 40491850
Inflammation is a protective response of the body, but when excessive or prolonged, it can contribute to disease progression and tissue damage. Identifying more effective and less toxic drugs for treating both acute and chronic inflammatory diseases is a major challenge. Organelle-targeting strategies, which deliver drugs directly to specific organelles, …
Microbial Patterns in Newly Diagnosed Inflammatory Bowel Disease Revealed by Presence and Transcriptional Activity - Relationship to Diagnosis and Outcome
Publication Year: 2025 Source: Clin Exp Gastroenterol PMID: 40491932 DOI: 10.2147/CEG.S504459
BACKGROUND: As part of the IBD Character initiative, we examined an inception cohort and investigated mucosal microbiota composition and transcriptional activity in relation to clinical outcomes. METHODS: A cohort of 237 individuals were included from five countries: Crohn's disease (CD, n = 72), ulcerative colitis (UC, n = 57), symptomatic …
Comparing the effectiveness of different vaccines in individuals with and without autoimmune diseases: a study protocol for a target trial emulation
Publication Year: 2025 Source: Front Public Health PMID: 40492009 DOI: 10.3389/fpubh.2025.1583434
AIM: This article presents the study protocol of a retrospective cohort study designed to compare the effectiveness of herpes zoster, and influenza vaccines in individuals with multiple sclerosis (MS), chronic inflammatory bowel diseases (IBD), or chronic inflammatory rheumatic diseases (CIRD) to individuals without these diseases, using claims data of one …
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