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Patients with active inflammatory bowel disease lack immature peripheral blood plasmacytoid and myeloid dendritic cells
Publication Year: 2005 Source: Gut PMID: 15647187 DOI: 10.1136/gut.2004.040360
Both genetic and environmental factors have been implicated in the etiology of inflammatory bowel diseases (IBD) i.e., Crohn's disease (CD) and ulcerative colitis (UC). Polymorphisms in cytokine genes are likely to influence an individual's predisposition to IBD. In intron 2 of the interleukin-1 receptor antagonist (IL-1ra) gene, a variable number …
Comparison of magnetic resonance imaging colonography with conventional colonoscopy for the assessment of intestinal inflammation in patients with inflammatory bowel disease: a feasibility study
Publication Year: 2005 Source: Gut PMID: 15647190 DOI: 10.1136/gut.2003.037390
Mucosal injury and inflammation are cardinal manifestations of inflammatory bowel diseases (IBD), arising when the effects of cytotoxic factors and conditions overwhelm the cell's capacity for defense (i.e. cytoprotection) or repair. To date, most research in this area has focused primarily on agents and processes involved in producing tissue injury, …
Magnetic resonance colonography for the detection of inflammatory diseases of the large bowel: quantifying the inflammatory activity
Publication Year: 2005 Source: Gut PMID: 15647191 DOI: 10.1136/gut.2003.037085
Inflammatory bowel disease (IBD) is a chronic immunoinflammatory response to an stimulus that activates a chain of cellular mediators causing intestinal damage. One of the most well recognized proinflammatory mediators involved in the pathogenesis of IBD is tumor necrosis factor alpha (TNFalpha). The treatment of IBD has advanced in parallel …
Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression
Publication Year: 2005 Source: Biochem Pharmacol PMID: 15652231 DOI: 10.1016/j.bcp.2004.10.015
BACKGROUND & AIMS: Activation of NF-kappaB/Rel has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Various drugs used in the treatment of IBD, such as glucocorticoids, 5-aminosalicylic acid, and sulfasalazine, interfere with NF-kappaB/Rel signaling. The aim of this study was to define the molecular mechanism by which sulfasalazine …
Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases
Publication Year: 2005 Source: Am J Gastroenterol PMID: 15654782 DOI: 10.1111/j.1572-0241.2005.40615.x
BACKGROUND & AIMS: To investigate the role of inducible costimulator (ICOS), a new member of the CD28 family involved in regulation of T-cell activation and chronic intestinal inflammation, we assessed its expression and functional role in patients with inflammatory bowel disease (IBD). METHODS: Expression of ICOS, CD28, and cytotoxic T-lymphocyte …
A STAT need for human immunologic studies to understand inflammatory bowel disease
Publication Year: 2005 Source: Am J Gastroenterol PMID: 15654783 DOI: 10.1111/j.1572-0241.2005.41382.x
OBJECTIVE: To assess the presence of thrombospondin (TSP) in normal and colonic disease and correlate its presence to survival in colorectal cancers. MATERIALS AND METHODS: A specific antibody was used to stain paraffin-embedded sections of human colorectal disease (103 carcinomas, 10 inflammatory bowel disease (IBD), 10 diverticulosis and 10 normal). …
Variants of CARD15 are associated with an aggressive clinical course of Crohn's disease--an IG-IBD study
Publication Year: 2005 Source: Am J Gastroenterol PMID: 15654786 DOI: 10.1111/j.1572-0241.2005.40705.x
BACKGROUND & AIMS: Defective suppressor/regulatory T-cell activation has been proposed as a mechanism to explain the uncontrolled inflammatory process seen in inflammatory bowel disease (IBD). Previous studies have suggested that inappropriate activation of CD4+ T cells may occur in the gastrointestinal tract in these patients. Because suppressor/regulatory T cells are …
Conditional probability methods for haplotyping in pedigrees
Publication Year: 2004 Source: Genetics PMID: 15342540 DOI: 10.1534/genetics.103.021055
Multipoint interval mapping (MIM) and the MAPMAKER/SIBS program (M/S) are two methods of mapping quantitative loci by examining identity by descent (IBD) sharing in a region spanned by multiple microsatellite DNA markers. For the purpose of comparison, we simulated a quantitative trait controlled by a two-locus model, and evaluated the …
Targeting Therapy in Pediatric Inflammatory Bowel Disease
Publication Year: 2004 Source: Curr Treat Options Gastroenterol PMID: 15345210 DOI: 10.1007/s11938-004-0052-y
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Review article: bone disease in inflammatory bowel disease
Publication Year: 2004 Source: Aliment Pharmacol Ther PMID: 15352893 DOI: 10.1111/j.1365-2036.2004.02057.x
In many animal species different intestinal Helicobacter species have been described and a few species are associated with intestinal infection. In humans, the only member of the Helicobacter family which is well described in literature is Helicobacter pylori. No other Helicobacter-associated diseases have definitely been shown in humans. We developed …
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