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Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety
Publication Year: 2004 Source: Clin Gastroenterol Hepatol PMID: 15354273 DOI: 10.1016/s1542-3565(04)00344-1
BACKGROUND: Tissue inhibitors of metalloproteinases (TIMPs) play a key role in tissue degradation and remodeling. Since chronic inflammation is associated with tissue remodeling in inflammatory bowel disease (IBD), we evaluated serum TIMP-1 and TIMP-4 levels in IBD patients, in comparison with healthy controls (HC). METHODS: TIMP-1, TIMP-2 and TIMP-4 serum …
A genetic contribution to inflammatory bowel disease in Iceland: a genealogic approach
Publication Year: 2004 Source: Clin Gastroenterol Hepatol PMID: 15354281 DOI: 10.1016/s1542-3565(04)00351-9
The diagnosis of inflammatory bowel disease (IBD) in a proband increases the probability of a parallel IBD diagnosis in a family member. In this study, we were able to confirm the IBD diagnosis in 35 (9.9 percent) of the relatives of 352 registry probands. To confirm a proband's report of …
Aortic aneurysm repair is associated with a lower inflammatory response compared with surgery for inflammatory bowel disease
Publication Year: 2004 Source: Eur Surg Res PMID: 15359089 DOI: 10.1159/000079911
It is now well established that the intestinal flora plays an important role in the pathogenesis of inflammatory bowel disease (IBD). However, whether bacteria serve as the sole target of the immune response in this process or whether they act indirectly by triggering an anti-self response is still unclear. We …
More about Helicobacter pylori, antibiotics and IBD
Publication Year: 2004 Source: Helicobacter PMID: 15361088 DOI: 10.1111/j.1083-4389.2004.00259.x
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Cost of illness of inflammatory bowel disease in the UK: a single centre retrospective study
Publication Year: 2004 Source: Gut PMID: 15361497 DOI: 10.1136/gut.2004.041616
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Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease
Publication Year: 2004 Source: Gastroenterology PMID: 15362034 DOI: 10.1053/j.gastro.2004.06.049
Schizophrenia candidate regions 33-51 cM in length on chromosomes 5q, 6q, 10p, and 13q were investigated for genetic linkage with mapped markers with an average spacing of 5.64 cM. We studied 734 informative multiplex pedigrees (824 independent affected sibling pairs [ASPs], or 1,003 ASPs when all possible pairs are counted), …
Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bones
Publication Year: 2004 Source: Gastroenterology PMID: 15362035 DOI: 10.1053/j.gastro.2004.06.013
Comment in Gut. 2000 Jul;47(1):12-4. BACKGROUND/AIMS: Alterations in synthesis and breakdown of extracellular matrix components are known to play a crucial role in tissue remodelling during inflammation and wound healing. Degradation of collagens is highly regulated by a cascade of matrix metalloproteinases (MMPs). The current study was therefore designed to …
Mesalamine in IBD: multiple hats?
Publication Year: 2004 Source: Gastroenterology PMID: 15362058 DOI: 10.1053/j.gastro.2004.07.029
BACKGROUND AND AIMS: Iron deficiency anemia (IDA) is a common problem in patients with Inflammatory Bowel Disease (IBD) and has a significant negative impact on quality of life. The aim was to compare the clinical efficacy of intravenous (IV) versus oral (PO) iron replacement in adult IBD with iron deficiency …
The diagnostic yield of stool pathogen studies during relapses of inflammatory bowel disease
Publication Year: 2004 Source: J Clin Gastroenterol PMID: 15365403 DOI: 10.1097/01.mcg.0000139057.05297.d6
BACKGROUND: Fecal calprotectin (FC) has been proposed as a marker of inflammatory bowel disease (IBD), but few studies have evaluated its usefulness in patients with chronic diarrhea of various causes. We evaluated the diagnostic accuracy of a FC assay in identifying "organic" causes of chronic diarrhea in consecutive adults and …
GM haplotype diversity of 82 populations over the world suggests a centrifugal model of human migrations
Publication Year: 2004 Source: Am J Phys Anthropol PMID: 15365983 DOI: 10.1002/ajpa.10405
Quantitative trait loci (QTL) for growth and fatness traits have previously been identified on chromosomes 4 and 7 in several experimental pig populations. The segregation of these QTL in commercial pigs was studied in a sample of 2713 animals from five different populations. Variance component analysis (VCA) using a marker-based …
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