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Molecular and ecological evidence for small-scale isolation by distance in an endangered damselfly, Coenagrion mercuriale
Publication Year: 2004 Source: Mol Ecol PMID: 15367110 DOI: 10.1111/j.1365-294X.2004.02300.x
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Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice
Publication Year: 2004 Source: Eur J Immunol PMID: 15368285 DOI: 10.1002/eji.200324833
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Extensive antigenic changes in an atypical isolate of very virulent infectious bursal disease virus and experimental clinical control of this virus with an antigenically classical live vaccine
Publication Year: 2004 Source: Avian Pathol PMID: 15370040 DOI: 10.1080/03079450410001724049
Oral dextran sodium sulfate (DSS, 3%) produces experimental colitis with many features of human inflammatory bowel disease (IBD), (leukocyte extravasation, cachexia, and histopathology). Previous studies suggest that the inducible nitric oxide synthase (iNOS) in blood cells or in the endothelium contribute to this injury. However, until now no study has …
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase
Publication Year: 2004 Source: J Biol Chem PMID: 15371438 DOI: 10.1074/jbc.M406307200
Since glycolipid biosynthesis is potentially involved in immunological and inflammatory responses, we tested the effect of a novel inhibitor of intracellular glycolipid biosynthesis N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin (AMP-DNM) in two hapten-induced colitis models: trinitrobenzene sulphonic acid (TNBS)- and oxazolone (4-ethoxymethylene-2phenyl-2oxazoline-5-one; Oxa)-induced colitis. AMP-DNM was given either by intraperitoneal injection or orally via the …
The clinical significance of focally enhanced gastritis
Publication Year: 2004 Source: Am J Surg Pathol PMID: 15371951 DOI: 10.1097/01.pas.0000138182.97366.b4
Inflammatory bowel disease (IBD) is characterized by a chronically inflamed mucosa of the gastrointestinal tract, caused by an underlying immune imbalance and triggered by luminal substances, including bacteria. Mucus forms a gel layer covering the gastrointestinal tract, acting as a semi-permeable barrier between the lumen and the epithelium. Mucins, the …
Indium-labelled human gut-derived T cells from healthy subjects with strong in vitro adhesion to MAdCAM-1 show no detectable homing to the gut in vivo
Publication Year: 2004 Source: Clin Exp Immunol PMID: 15373907 DOI: 10.1111/j.1365-2249.2004.02578.x
BACKGROUND AND AIMS: The intestinal bacterial microflora plays an important role in the aetiology of inflammatory bowel disease (IBD). As most of the colonic bacteria cannot be identified by culture techniques, genomic technology can be used for analysis of the composition of the microflora. PATIENTS AND METHODS: The mucosa associated …
Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease
Publication Year: 2004 Source: Clin Immunol PMID: 15380529 DOI: 10.1016/j.clim.2004.05.004
Chronic intestinal inflammation, as seen in inflammatory bowel disease (IBD), results from an aberrant and poorly understood mucosal immune response to the microbiota of the gastrointestinal tract in genetically susceptible individuals. Here we used serological expression cloning to identify commensal bacterial proteins that could contribute to the pathogenesis of IBD. …
[Isotretinoin and ulcerous colitis]
Publication Year: 2004 Source: An Sist Sanit Navar PMID: 15381956 DOI: 10.4321/s1137-66272004000300009
Musculoskeletal manifestations are the most common extra-intestinal complication of inflammatory bowel disease (IBD). They are part of the clinical spectrum of spondylarthropathies and include different articular manifestations. In addition to axial symptoms, peripheral findings such as seronegative oligoarthritis, dactylitis, and enthesopathy commonly occur, sometimes representing the only manifestation. Wide ranges …
Animal models of inflammatory bowel disease
Publication Year: 2004 Source: J Pharmacol Toxicol Methods PMID: 15385082 DOI: 10.1016/j.vascn.2003.12.002
The Crohn's and Colitis Foundation of Canada (CCFC) has established a national bank for tissue, serum and blood from patients with inflammatory bowel disease (IBD). Investigators from across the country submit material to the bank together with clinical data. Investigators may access their own patient information from the bank for …
Soluble selectins, sICAM, sVCAM, and angiogenic proteins in different activity groups of patients with inflammatory bowel disease
Publication Year: 2004 Source: Dig Dis Sci PMID: 15387356 DOI: 10.1023/b:ddas.0000037822.55717.31
CD4+CD25+ regulatory T cells have been extensively studied during the last decade, but how these cells exert their regulatory function on pathogenic effector T cells remains to be elucidated. Naive CD4+ T cells transferred into T cell-deficient mice strongly expand and rapidly induce inflammatory bowel disease (IBD). Onset of this …
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