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A genome scan in 260 inflammatory bowel disease-affected relative pairs
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15472510 DOI: 10.1097/00054725-200409000-00004
Erratum in Gut. 2004 Nov;53(11):1722. BACKGROUND AND AIMS: Two divergent patterns of mortality for smoking related diseases in ulcerative colitis and Crohn's disease patients were suggested in a previous population based study in Florence, Italy. Long term follow up (median 15 years) was completed to re-evaluate mortality in this Mediterranean …
Intracellular polyamine levels of intestinal epithelial cells in inflammatory bowel disease
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15472512 DOI: 10.1097/00054725-200409000-00006
Coenagrion mercuriale (Charpentier) (Odonata: Zygoptera) is one of Europe's most threatened damselflies and is listed in the European Habitats directive. We combined an intensive mark-release-recapture (MRR) study with a microsatellite-based genetic analysis for C. mercuriale from the Itchen Valley, UK, as part of an effort to understand the dispersal characteristics …
Altered immune system glycosylation causes colitis in alpha1,2-fucosyltransferase transgenic mice
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15472514 DOI: 10.1097/00054725-200409000-00008
OBJECTIVES: The Inflammatory Bowel Disease Questionnaire (IBDQ) is a disease-specific questionnaire for assessing health-related quality of life. The main objective of this study is to assess three main areas of the validation of the Greek IBDQ: internal validity, designating items to dimensions, and selecting items for a short form. An …
Intestinal interleukin-13 in pediatric inflammatory bowel disease patients
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15472520 DOI: 10.1097/00054725-200409000-00014
BACKGROUND AND AIMS: The strong clinical association between primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) suggests common factors in their pathogenesis. Smoking, previous appendectomy, and tonsillectomy have been associated with a decreased risk of developing UC. In this study, our aim was to examine these risk factors in patients …
Pharmacokinetics of mesalazine pellets in children with inflammatory bowel disease
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15472525 DOI: 10.1097/00054725-200409000-00019
BACKGROUND AND AIMS: Inflammatory bowel diseases (IBD) evoke a damage-repair process accompanied by the activation of apoptotic genes. Data on transglutaminase (TG) expression in apoptotic cells in inflamed colonic epithelium has not been reported, although TG cross-links proteins within typical apoptotic bodies in various cell lines. In an experimental model …
Assessing the demand for psychological care in chronic diseases: development and validation of a questionnaire based on the example of inflammatory bowel disease
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15472527 DOI: 10.1097/00054725-200409000-00021
Comment in J Hepatol. 2004 Aug;41(2):327-32. BACKGROUND/AIMS: Intercellular adhesion molecule-1 (ICAM-1, CD54) gene polymorphisms have been implicated in the susceptibility to a range of inflammatory diseases, including inflammatory bowel disease (IBD). Primary sclerosing cholangitis (PSC) is an immune-mediated chronic cholestatic liver disease associated with IBD. ICAM-1 is expressed on proliferating …
Acute sinusoidal obstruction syndrome after 6-thioguanine therapy for Crohn's disease
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15472529 DOI: 10.1097/00054725-200409000-00023
It is well established that smoking cigarettes is associated with Crohn's disease (CD) and that non-smoking is associated with ulcerative colitis (UC). Furthermore, there is convincing evidence that smoking cigarettes has a negative effect on the course of CD, and that smoking cigarettes may improve the disease severity or have …
C-reactive protein as a marker for inflammatory bowel disease
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15472532 DOI: 10.1097/00054725-200409000-00026
Managing IBD in children and adolescents requires attention to issues unique to these age groups. The spectrum of presenting signs and symptoms is broad and often, subtle. Physician awareness of intestinal and extra-intestinal features prompts earlier diagnosis and intervention. The focus of treatment is not limited to intestinal symptoms, but …
Regulatory T cells: peace keepers in the gut
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15472533 DOI: 10.1097/00054725-200409000-00027
Azathioprine (AZA) or 6-mercaptopurine (6-MP) are the immunosuppressive drugs of choice in the treatment of inflammatory bowel disorders (IBD). Optimal dosage for AZA is around 2.5 mg/kg body weight and induction of remission by these drugs may take 6 - 7 months. Intramuscularly applied Methotrexate (MTX) is the second choice, …
Guidelines for immunizations in patients with inflammatory bowel disease
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15472534 DOI: 10.1097/00054725-200409000-00028
BACKGROUND: Pairs of related individuals are widely used in linkage analysis. Most of the tests for linkage analysis are based on statistics associated with identity by descent (IBD) data. The current biotechnology provides data on very densely packed loci, and therefore, it may provide almost continuous IBD data for pairs …
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