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To (I)B(D) or NOD2 (I)B(D)--are paneth cells the answer?
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15472538 DOI: 10.1097/00054725-200409000-00032
Comment in Digestion. 2011;84(3):236-7. BACKGROUND: Alcohol consumption is a potential trigger for inflammatory bowel disease (IBD) flare because of alcohol-induced oxidative stress and its deleterious effects on gut barrier function. Additionally, we have recently shown that alcohol consumption is associated with more symptoms in IBD. However, it is not known …
The spectrum of gastrointestinal toxicity and effect on disease activity of selective cyclooxygenase-2 inhibitors in patients with inflammatory bowel disease
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15475742 DOI: 10.1097/00054725-200407000-00005
OBJECTIVE: To determine whether inflammatory bowel disease (IBD) is associated with increased risk for adverse perinatal outcome. METHODS: A case-control study of 116 singleton pregnancies with IBD compared to 56,398 singleton controls delivered between 1986 and 2001. RESULTS: Patients with IBD were slightly older (32.8 vs. 30.6 years, p < …
Formation of platelet-leukocyte aggregates in inflammatory bowel disease
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15475744 DOI: 10.1097/00054725-200407000-00007
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Clinical relevance of transabdominal ultrasonography and magnetic resonance imaging in patients with inflammatory bowel disease of the terminal ileum and large bowel
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15475745 DOI: 10.1097/00054725-200407000-00008
AIM: To investigate the presence of inflammatory bowel disease (IBD) and to evaluate the progression of bowel involvement after two years' follow-up in seven patients affected by glycogen storage disease type Ib (GSDIb). METHODS: Seven patients (5F, 2M, aged 4.5-20.6 y) entered the study. Bowel involvement was evaluated by ileocolonoscopy …
The role of quality of care in health-related quality of life in patients with IBD
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15475747 DOI: 10.1097/00054725-200407000-00010
Humans are constantly exposed to a wide variety of microorganisms that can cause infection. In self-defense, the human host has evolved complex protective mechanisms, and Toll-like receptors (TLRs) have emerged as a central point in defense. These receptors bind molecular structures that are expressed by microbes but are not expressed …
Successful therapy of refractory pyoderma gangrenosum and periorbital phlegmona with tacrolimus (FK506) in ulcerative colitis
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15475751 DOI: 10.1097/00054725-200407000-00014
A common practice among researchers performing linkage studies is the use of equal allele frequencies as input when reporting p-values from computer linkage programs such as S.A.G.E. SIBPAL. Our results, using 5,000 sets from a uniform-prior distribution of allele frequencies, showed that such input may be problematic. Further, we found …
Aortic mural thrombi in patients with inflammatory bowel disease: report of two cases and review of the literature
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15475753 DOI: 10.1097/00054725-200407000-00016
OBJECTIVE: This study aims to compare generic coping styles adopted by adolescents suffering from inflammatory bowel disease (IBD) to styles used by their healthy peers, and to assess the association between coping styles and health-related quality of life (HRQoL). METHODS: A generic coping style instrument, a disease-related coping style instrument …
Communicating with patients with inflammatory bowel disease
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15475757 DOI: 10.1097/00054725-200407000-00020
BACKGROUND: A thrombotic etiology for inflammatory bowel disease (IBD) has been proposed as a result of its association with thromboembolic complications, smoking, the oral contraceptive pill, and the response of ulcerative colitis (UC) patients to heparin. We have previously demonstrated an increased prevalence of the Factor V Leiden mutation in …
Mechanisms of natural tolerance in the intestine: implications for inflammatory bowel disease
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15475760 DOI: 10.1097/00054725-200407000-00023
Comment in Sci Prog. 2002;85(Pt 1):1-11. Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory condition of the intestines that is clinically heterogenous. The cause(s) of IBD are currently unknown but the mechanisms of injury are immunological. Increasingly there is an emphasis on the study of the complex interactions at …
Opposite effect of oxidative stress on inducible nitric oxide synthase and haem oxygenase-1 expression in intestinal inflammation: anti-inflammatory effect of carbon monoxide
Publication Year: 2004 Source: J Pathol PMID: 15476266 DOI: 10.1002/path.1656
BACKGROUND & AIMS: Crohn's disease is a chronic inflammatory bowel disease (IBD) of unknown etiology. In this study, we investigated the hypothesis that dietary fatty acids, linoleic acid (LA) and oleic acid (OA), could be involved in the inflammatory response through stimulation of the neutrophil chemokine, IL-8. METHODS: Human intestinal …
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