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A genomewide search using an original pairwise sampling approach for large genealogies identifies a new locus for total and low-density lipoprotein cholesterol in two genetically differentiated isolates of Sardinia
Publication Year: 2004 Source: Am J Hum Genet PMID: 15478097 DOI: 10.1086/426155
The term indeterminate colitis (IC) is an interim, or preliminary, descriptive term used by pathologists for cases of inflammatory bowel disease (IBD) in which a definite diagnosis of ulcerative colitis (UC) or Crohn's disease (CD) cannot be established based on the information available at the time of surgical sign-out. Most …
Evaluation of assays for perinuclear antineutrophilic cytoplasmic antibodies and antibodies to Saccharomyces cerevisiae in dogs with inflammatory bowel disease
Publication Year: 2004 Source: Am J Vet Res PMID: 15478778 DOI: 10.2460/ajvr.2004.65.1279
BACKGROUND: Patients with inflammatory bowel disease (IBD) are thought to be at increased risk of venous thromboembolism (TE). However, the extent of this risk is not known. Furthermore, it is not known if this risk is specific for IBD or if it is shared by other chronic inflammatory diseases or …
A randomised controlled trial to assess the effectiveness and cost of a patient orientated self management approach to chronic inflammatory bowel disease
Publication Year: 2004 Source: Gut PMID: 15479685 DOI: 10.1136/gut.2003.034256
BACKGROUND: Since the plasma cytokine profile reflects the body's inflammatory response to injury, this study was designed to prospectively observe the plasma cytokine levels in response to the degree of different sorts of abdominal surgical trauma. METHODS: Plasma levels of TNF-alpha, type I TNF receptor (p55), type II TNF receptor …
Are Helicobacter species and enterotoxigenic Bacteroides fragilis involved in inflammatory bowel disease?
Publication Year: 2004 Source: Dig Dis Sci PMID: 15481314 DOI: 10.1023/b:ddas.0000042241.13489.88
BACKGROUND: Narcotic addiction can be a significant problem in inflammatory bowel disease (IBD). However, there are few published reports about this problem. METHODS: All patients prescribed narcotics chronically in the absence of demonstrable organic pathology were identified on the computerized Brisbane IBD Research Group database (n=332 patients with informative data …
Decreased total and corrected antioxidant capacity in patients with inflammatory bowel disease
Publication Year: 2004 Source: Dig Dis Sci PMID: 15481315 DOI: 10.1023/b:ddas.0000042242.22898.d9
A powerful approach to mapping the genes for complex traits is to study isolated founder populations, in which genetic heterogeneity and environmental noise are likely to be reduced and in which extended genealogical data are often available. Using graph theory, we applied an approach that involved sampling from the large …
Association between enhanced soluble CD40 ligand and prothrombotic state in inflammatory bowel disease
Publication Year: 2004 Source: Eur J Gastroenterol Hepatol PMID: 15489574 DOI: 10.1097/00042737-200411000-00011
BACKGROUND/AIMS: To investigate the potential value of the use of the fibrin glue-antibiotic mixture in the treatment of anal fistulae. MATERIALS AND METHODS: This study included 69 patients with idiopathic nonspecific anal fistulae. Patients with IBD (inflammatory bowel disease), TBC, actinomycosis, and cancer were excluded from the study. The microbiological …
Epidemiology of inflammatory bowel disease in adults who refer to gastroenterology care in Romania: a multicentre study
Publication Year: 2004 Source: Eur J Gastroenterol Hepatol PMID: 15489575 DOI: 10.1097/00042737-200411000-00012
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Ignoring linkage disequilibrium among tightly linked markers induces false-positive evidence of linkage for affected sib pair analysis
Publication Year: 2004 Source: Am J Hum Genet PMID: 15492927 DOI: 10.1086/426000
Comment in Apoptosis. 2004 Sep;9(5):657-8; author reply 659. Inflammatory conditions are characterized by activation of the transcription factor nuclear factor kappa B (NF-kappaB), resulting in the expression of NF-kappaB-regulated, inflammation-related genes, such as inducible nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2). Expression of these genes contributes to the survival of …
Infection with cytomegalovirus in patients with inflammatory bowel disease: prevalence, clinical significance and outcome
Publication Year: 2004 Source: J Med Microbiol PMID: 15496396 DOI: 10.1099/jmm.0.45629-0
BACKGROUND: Although ãlpha-chemokines, such as interleukin (IL)-8 and epithelial neutrophil-activating peptide 78, are implicated in the pathogenesis of inflammatory bowel disease (IBD), little information is currently available on the expression and cellular source of growth-related gene product-alpha (GROalpha) and its functional relationship to other ãlpha-chemokines in the intestinal mucosa of …
Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease
Publication Year: 2004 Source: Clin Exp Immunol PMID: 15498044 DOI: 10.1111/j.1365-2249.2004.02599.x
Inflammatory bowel disease (IBD) is associated with an increased risk of lymphoma, which is usually extraintestinal but sometimes may involve the diseased bowel itself. Most lymphomas described in this setting are of non-Hodgkin's type, but rare cases of Hodgkin's disease (HD) have been reported. We describe the clinicopathologic and molecular …
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