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Rapid detection of common CARD15 variants in patients with inflammatory bowel disease
Publication Year: 2004 Source: Mol Diagn PMID: 15527324 DOI: 10.1007/BF03260052
Most multipoint linkage programs assume linkage equilibrium among the markers being studied. The assumption is appropriate for the study of sparsely spaced markers with intermarker distances exceeding a few centimorgans, because linkage equilibrium is expected over these intervals for almost all populations. However, with recent advancements in high-throughput genotyping technology, …
Elevated serum procollagen type III peptide in splanchnic and peripheral circulation of patients with inflammatory bowel disease submitted to surgery
Publication Year: 2004 Source: BMC Gastroenterol PMID: 15527511 DOI: 10.1186/1471-230X-4-29
Thromboembolic events are a known complication in inflammatory bowel disease (IBD). We report on 2 young women with IBD and aortic mural thrombi as a source of arterioarterial embolization to the lower limbs resulting in significant morbidity. The first case was a 36-year-old woman with severe ulcerative colitis who presented …
Relevance of serologic studies in inflammatory bowel disease
Publication Year: 2004 Source: Curr Gastroenterol Rep PMID: 15527678 DOI: 10.1007/s11894-004-0070-x
Although little data exist directly evaluating the utility and safety of endoscopy in the pregnant woman with IBD, it appears to be well tolerated by both mother and fetus, and provides useful clinical information. When performed to evaluate gastrointestinal bleeding, EGD has a high diagnostic yield, while EGD for nausea …
Management of extraintestinal manifestations and other complications of inflammatory bowel disease
Publication Year: 2004 Source: Curr Gastroenterol Rep PMID: 15527681 DOI: 10.1007/s11894-004-0073-7
Our objective is the development of robust methods for assessment of evidence for linkage of loci affecting a complex trait to a marker linkage group, using data on extended pedigrees. Using Markov chain Monte Carlo (MCMC) methods, it is possible to sample realizations from the distribution of gene identity by …
Immunization of chickens with VP2 protein of infectious bursal disease virus expressed in Arabidopsis thaliana
Publication Year: 2004 Source: Avian Dis PMID: 15529992 DOI: 10.1637/7074
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Clinical assessment of disease activity for canine inflammatory bowel disease
Publication Year: 2004 Source: J Am Anim Hosp Assoc PMID: 15533963 DOI: 10.5326/0400437
To assess the association between symptomatic relapse of inflammatory bowel disease (IBD) and superinfection with enteropathogenic microorganisms, we determined prospectively the incidence of infections with enteropathogenic bacteria, protozoa, and helminths in patients with confirmed longstanding IBD. Sixty-four patients with IBD (49 with Crohn's disease [CD] and 15 with ulcerative colitis …
Epidemiology of chronic inflammatory bowel disease in the Northern area of Huelva
Publication Year: 2004 Source: Rev Esp Enferm Dig PMID: 15537375 DOI: 10.4321/s1130-01082004001000003
Comment in Clin Gastroenterol Hepatol. 2004 Jan;2(1):14-6. BACKGROUND AND AIMS: Wireless capsule enteroscopy (WCE) offers the potential to directly visualize the entire small bowel and identify superficial lesions not detected by traditional endoscopy and radiography. The aim of this study is to assess the clinical utility of WCE in the …
The identification and optimization of orally efficacious, small molecule VLA-4 antagonists
Publication Year: 2004 Source: Curr Top Med Chem PMID: 15544538 DOI: 10.2174/1568026043387467
A correct diagnosis, adequate assessment of disease activity, avoidance of surgery by endoscopic interventions, and effective cancer surveillance make endoscopy crucial in the management of inflammatory bowel diseases (IBDs). Impressive technical developments of several endoscopic techniques over the past few decades have allowed a detailed visual impression of the affected …
Reduced joint pain after short-term duodenal administration of seal oil in patients with inflammatory bowel disease: comparison with soy oil
Publication Year: 2004 Source: Scand J Gastroenterol PMID: 15545167 DOI: 10.1080/00365520410009429
The endothelium is involved in the pathogenesis of inflammatory bowel disease (IBD). So far knowledge of the precise role of soluble adhesion molecules and angiogenic factors at different periods of activity in IBD is scarce or contradictory. Our goal in this study was to determine the serum levels of adhesion …
A role for proteinase-activated receptor-1 in inflammatory bowel diseases
Publication Year: 2004 Source: J Clin Invest PMID: 15545995 DOI: 10.1172/JCI21689
BACKGROUND: The trefoil factors (TFF1-3) are cysteine-rich peptides expressed in the gastrointestinal tract where they play a critical role in mucosal protection and repair. The expression is up-regulated at sites of ulceration in various chronic inflammatory diseases. Recently, we presented an ELISA method for measurement of TFF3. The aims of …
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