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[TNF-alpha inhibitors in inflammatory bowel disease]
Publication Year: 2004 Source: Med Clin (Barc) PMID: 15546523 DOI: 10.1016/s0025-7753(04)74622-9
Genomewide scanning has been used to identify chromosomal regions encoding susceptibility loci to inflammatory bowel disease (IBD). The greatest evidence for linkage to IBD has been reported for a region of chromosome 12q14 surrounding the microsatellite marker D12S83, with a logarithm of odds score of 5.47 and a positive transmission …
Altered expression of angiogenic factors in the VEGF-Ets-1 cascades in inflammatory bowel disease
Publication Year: 2004 Source: J Gastroenterol PMID: 15549445 DOI: 10.1007/s00535-004-1423-9
BACKGROUND: Inflammatory bowel disease (IBD) is associated with altered apoptosis and increased levels of Th1 cytokines (IL-12, TNF-alpha, and IFN-gamma). These proinflammatory events may result from dysfunctional IL-4/Stat6 signal transduction that normally promotes Th2 lymphocyte differentiation and consequential down-regulation of the immune response. The goal of the present study was …
Evaluation of venous thromboembolism and coagulation-fibrinolysis markers in Japanese patients with inflammatory bowel disease
Publication Year: 2004 Source: J Gastroenterol PMID: 15549447 DOI: 10.1007/s00535-004-1426-6
OBJECTIVES: Young children are thought to be a unique subset of pediatric patients with inflammatory bowel disease (IBD). The authors' objective was to evaluate the differences in initial clinical presentation of young and older children with IBD and to determine whether a positive family history of IBD is associated with …
Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle
Publication Year: 2004 Source: Immunology PMID: 15554920 DOI: 10.1111/j.1365-2567.2004.01984.x
BACKGROUND: In the hypothesis that the increased collagen metabolism in the intestinal wall of patients affected by inflammatory bowel disease (IBD) is reflected in the systemic circulation, we aimed the study to evaluate serum level of procollagen III peptide (PIIIP) in peripheral and splanchnic circulation by a commercial radioimmunoassay of …
A prospective comparative study of ASCA and pANCA in Chinese and Caucasian IBD patients
Publication Year: 2004 Source: Am J Gastroenterol PMID: 15555001 DOI: 10.1111/j.1572-0241.2004.40486.x
Immunological abnormalities are implicated in the pathogenesis of inflammatory bowel disease (IBD), that is, Crohn's disease and ulcerative colitis. In particular, Crohn's disease is considered to be a T helper type 1 (Th1)-shifted disease. Chemokines and their receptors are involved in various immune responses including Th1- and Th2 responses. In …
Serologic testing with ANCA, ASCA, and anti-OmpC in children and young adults with Crohn's disease and ulcerative colitis: diagnostic value and correlation with disease phenotype
Publication Year: 2004 Source: Am J Gastroenterol PMID: 15555007 DOI: 10.1111/j.1572-0241.2004.40369.x
AIM: To investigate the effect of dermatan sulfate (DS) derivatives on platelet surface P-selectin expression and blood activated protein C (APC) activity in patients with inflammatory bowel disease (IBD), and to clarity the anti-inflammatory mechanism of DS derivatives. METHODS: Dermatan sulfate (DS) was sulfated with chlorosulfonic acid to prepare polysulfated …
Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis
Publication Year: 2004 Source: J Exp Med PMID: 15557349 DOI: 10.1084/jem.20041035
We have evaluated the applicability of a new Digital X-ray Radiogrammetry (DXR) system in a Dutch Caucasian pediatric population. For this study we enrolled 535 healthy participants who all signed an informed consent form. In addition, 20 children suffering from inflammatory bowel disease (IBD) and juvenile chronic arthritis (JCA) were …
[Regulatory T cells and inflammatory bowel diseases]
Publication Year: 2004 Source: Nihon Rinsho Meneki Gakkai Kaishi PMID: 15559318 DOI: 10.2177/jsci.27.302
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Inflammatory bowel disease: autoimmune or immune-mediated pathogenesis?
Publication Year: 2004 Source: Clin Dev Immunol PMID: 15559364 DOI: 10.1080/17402520400004201
OBJECTIVES: Modelling of variation in identical-by-descent (IBD) allele sharing using covariates can increase power to detect linkage, identify covariate-defined subgroups linked to particular marker regions, and improve the design of subsequent studies to localize genes and characterize their effects. In this report, we highlight issues that arise in studies of …
Evidence of p-glycoprotein sequence diversity in cyathostomins
Publication Year: 2004 Source: J Parasitol PMID: 15562598 DOI: 10.1645/GE-3312
Human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) protein was recently identified as a binding partner for HIV-1 integrase (IN) in human cells. In this work, we used biochemical and bioinformatic approaches to define the domain organization of LEDGF/p75. Using limited proteolysis and deletion mutagenesis we show that the protein …
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