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Malignant peritoneal mesothelioma in a pediatric patient mimicking inflammatory bowel disease
Publication Year: 2004 Source: Dig Dis Sci PMID: 15139493 DOI: 10.1023/b:ddas.0000020498.50909.54
Currently used standard treatment in IBD is effective and sufficient for the majority of patients. Published numbers regarding therapy refractoriness are probably related to referral centers and not representative. Pharmacological optimization of available drugs improves the standard situation further. Biological therapies in a larger meaning are studied intensively, but obviously …
Lymphocyte homing in the pathogenesis of extra-intestinal manifestations of inflammatory bowel disease
Publication Year: 2004 Source: Clin Med (Lond) PMID: 15139741 DOI: 10.7861/clinmedicine.4-2-173
Inflammatory intestinal pathology has been reported in children with regressive autism (affected children). Detailed analysis of intestinal biopsies in these children indicates a novel lymphocytic enterocolitis with autoimmune features; however, links with cognitive function remain unclear. To characterize further, the nature and extent of this disease we examined the mucosal …
Immunological aspects of heat-shock proteins-the optimum stress of life
Publication Year: 2004 Source: Mol Immunol PMID: 15140573 DOI: 10.1016/j.molimm.2004.02.001
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Fucoidan derived from Cladosiphon okamuranus Tokida ameliorates murine chronic colitis through the down-regulation of interleukin-6 production on colonic epithelial cells
Publication Year: 2004 Source: Clin Exp Immunol PMID: 15147344 DOI: 10.1111/j.1365-2249.2004.02462.x
BACKGROUND/PURPOSE: Transfection of the HLA-B27 gene into normal Fischer rats induces phenotypic changes similar to inflammatory bowel disease (IBD). This study investigated the benefits of 2 doses of hepatocyte growth factor (HGF) on the manifestations of IBD in this rat model. METHODS: Fischer rats and HLA-B27 rats were divided into …
Review: psychosocial issues in pediatric inflammatory bowel disease
Publication Year: 2004 Source: J Pediatr Psychol PMID: 15148347 DOI: 10.1093/jpepsy/jsh027
Individuals with inflammatory bowel disease (IBD) often exhibit anxiety and depression, pain and reduced energy but may not adequately develop self-care agency (SCA) to manage IBD. The purpose of this study was to examine whether SCA is related to quality of life in adults diagnosed with IBD. The sample of …
Nutritional Therapy in Inflammatory Bowel Disease
Publication Year: 2004 Source: Curr Treat Options Gastroenterol PMID: 15149581 DOI: 10.1007/s11938-004-0040-2
With the heterogeneous clinical presentation of IBD, endoscopy plays an integral role in the initial diagnosis of ulcerative colitis and Crohn's disease. Although radiographic tests often are supplemental in the work-up of IBD, colonoscopy with biopsy is the test of choice if IBD is suspected and is more sensitive than …
Inflammatory bowel disease: a complex group of genetic disorders
Publication Year: 2004 Source: Best Pract Res Clin Gastroenterol PMID: 15157820 DOI: 10.1016/j.bpg.2004.01.001
Peristomal pyoderma gangrenosum (PPG) is a variant of pyoderma gangrenosum (PG) that is more refractory to treatment. It is a cause of severe morbidity and poses a therapeutic challenge for the clinician. Infliximab (Remicade(R); Centocor, Malvern, PA, USA) is a chimeric monoclonal antibody directed against tumour necrosis factor-alpha that has …
Epidemiology of IBD during the twentieth century: an integrated view
Publication Year: 2004 Source: Best Pract Res Clin Gastroenterol PMID: 15157821 DOI: 10.1016/j.bpg.2003.12.002
Williams & Blangero (1999) derived closed form expressions for the power of a univariate variance components test of linkage for a variety of pedigree structures. We have extended their results by investigating the effect of including monozygotic twins in the design on the power to detect linkage. Specifically, we determined …
Tobacco and IBD: relevance in the understanding of disease mechanisms and clinical practice
Publication Year: 2004 Source: Best Pract Res Clin Gastroenterol PMID: 15157822 DOI: 10.1016/j.bpg.2003.12.003
Current incidence figures on ulcerative colitis and Crohn's disease--presented in a recent multicenter study in Europe--are given, and differences in the frequency and clinical appearances of the two conditions are discussed. Trends in the frequency and clinical appearance of inflammatory bowel disease during the twentieth century are summarized, as well …
Specificities of inflammatory bowel disease in childhood
Publication Year: 2004 Source: Best Pract Res Clin Gastroenterol PMID: 15157824 DOI: 10.1016/j.bpg.2004.01.002
BACKGROUND: Osteopontin represents a multifunctional molecule playing a pivotal role in chronic inflammatory and autoimmune diseases. Its expression is increased in inflammatory bowel disease (IBD). The aim of our study was to analyze the association of osteopontin (OPN/SPP1) gene variants in a large cohort of IBD patients. METHODOLOGY/PRINCIPAL FINDINGS: Genomic …
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