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Host-bacterial interactions in inflammatory bowel disease
Publication Year: 2004 Source: Clin Sci (Lond) PMID: 15212627 DOI: 10.1042/CS20040136
The profile of tissue kallikrein (TK) and its inhibitor, kallistatin was evaluated in patients with active ulcerative colitis (UC) and Crohn's disease (CD). Tissue kallikrein is mainly localized to goblet cells and kallistatin to epithelial cells of human intestine. Intestinal tissue kallikrein (ITK) and kallistatin are significantly decreased in inflamed …
[Precancerous lesions and IBD - pathological aspects]
Publication Year: 2004 Source: Gastroenterol Clin Biol PMID: 15213674 DOI: 10.1016/s0399-8320(04)94998-6
Not found
[Precancerous lesions and IBD endoscopic features]
Publication Year: 2004 Source: Gastroenterol Clin Biol PMID: 15213675 DOI: 10.1016/s0399-8320(04)94999-8
Comment in Inflamm Bowel Dis. 1999 Nov;5(4):283-4.
CXCR1-binding chemokines in inflammatory bowel diseases: down-regulated IL-8/CXCL8 production by leukocytes in Crohn's disease and selective GCP-2/CXCL6 expression in inflamed intestinal tissue
Publication Year: 2004 Source: Eur J Immunol PMID: 15214047 DOI: 10.1002/eji.200324807
The clinical course of inflammatory bowel disease (IBD) in dogs is characterized by spontaneous exacerbations and remissions, which makes assessment of disease burden difficult. The objectives of this study were to develop a scoring system for evaluation of canine IBD activity and to validate this scoring method by correlating it …
CCR5-Delta32 mutation is strongly associated with primary sclerosing cholangitis
Publication Year: 2004 Source: Genes Immun PMID: 15215889 DOI: 10.1038/sj.gene.6364113
Functional magnetic resonance imaging (fMRI) was used to examine the brain processing of capsaicin-induced painful stimulation in the alpha-chloralose anesthetized rat. Experiments were performed on a 9.4-T magnet (Magnex, UK) with Avance console (Bruker, Germany) using a surface coil tuned to 400.5 MHz centred over the rat forebrain. Gradient-echo images …
On the prediction of simultaneous inbreeding coefficients at multiple loci
Publication Year: 2004 Source: Genet Res PMID: 15219156 DOI: 10.1017/s0016672303006633
Although both sporadic colorectal cancer (CRC) and colitis-associated CRC arise from dysplastic precursor lesions and share several molecular alterations, the nature of the dysplasia and the frequency and timing of several of the key molecular changes differ enough to consider colitis-associated CRC a rather unique entity. To date, cancer surveillance …
Probiotics in the treatment of irritable bowel syndrome
Publication Year: 2004 Source: J Clin Gastroenterol PMID: 15220671 DOI: 10.1097/01.mcg.0000129271.98814.e2
Linkage studies have identified the inflammatory bowel disease (IBD)1 locus on chromosome 16 and the IBD2 locus on chromosome 12 to be involved in Crohn's disease. NOD2/CARD15 was identified as the gene of interest within the IBD1 region. However, linkage to this region could not be explained by NOD2/CARD15 alone. …
Very virulent infectious bursal disease virus in Egypt: epidemiology, isolation and immunogenicity of classic vaccine
Publication Year: 2004 Source: Vet Res Commun PMID: 15222739 DOI: 10.1023/b:verc.0000026657.29702.4e
Our previous study indicated that the interleukin (IL)-6/STAT-3 signal was up-regulated in inflammatory bowel disease (IBD) in both humans and animal models. We also discovered phosphorylated STAT-3 in the nucleus of the colonic epithelial cells in IBD mice. Intestinal epithelial cells (IEC) have been shown to secrete IL-6. Therefore, the …
Inflammatory bowel disease: the role of inflammatory cytokine gene polymorphisms
Publication Year: 2004 Source: Mediators Inflamm PMID: 15223609 DOI: 10.1080/09511920410001713529
BACKGROUND: Studies have shown an association between inflammatory bowel disease (IBD) and low bone density. Previous publications, however, measured only a single parameter, either T or Z score, making comparison of data difficult. OBJECTIVE: To assess the effect of disease factors on both T and Z scores in a population …
Sonographic diagnosis of colitis in children
Publication Year: 2004 Source: Eur Radiol PMID: 15232710 DOI: 10.1007/s00330-004-2358-5
The past decade has witnessed a tremendous expansion of our knowledge-base of genetics of inflammatory bowel disease. To a large extent, this progress reflects the scientific innovation and impact of the human genome project, which has fueled many laboratory-based studies focusing on the molecular genetics of Crohn's disease and ulcerative …
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