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Safety of infliximab treatment in pediatric patients with inflammatory bowel disease
Publication Year: 2004 Source: J Pediatr Gastroenterol Nutr PMID: 15319627 DOI: 10.1097/00005176-200409000-00008
Several genes have been reported recently to be associated with schizophrenia and bipolar disorder. Because of the complexity of the inheritance of these disorders, there is an urgent need to replicate these findings and to search for additional candidate genes. The study of genetic isolates is a powerful technique that …
Phylogeography of the Atlantic bonito (Sarda sarda) in the northern Mediterranean: the combined effects of historical vicariance, population expansion, secondary invasion, and isolation by distance
Publication Year: 2004 Source: Mol Phylogenet Evol PMID: 15324837 DOI: 10.1016/j.ympev.2004.04.009
A case of a 32-years old man with a long lasting history of inflammatory bowel disease (IBD) is described. He was treated in the past with adequate medical therapy with considerable improvement of the symptoms. However, after the resolution of the last episode of abdominal pain and diarrhoea, because of …
Patterns of genetic differention between populations of the specialized herbivore Macrosiphoniella tanacetaria (Homoptera, Aphididae)
Publication Year: 2004 Source: Heredity (Edinb) PMID: 15329663 DOI: 10.1038/sj.hdy.6800559
Linkage disequilibrium (LD) reflects coinheritance of an ancestral segment by chromosomes in a population. To begin to understand the effects of population history on the extent of LD, we model the length of a tract of identity-by-descent (IBD) between two chromosomes in a finite, random mating population. The variance of …
The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease
Publication Year: 2004 Source: Am J Gastroenterol PMID: 15330913 DOI: 10.1111/j.1572-0241.2004.30415.x
AIM: Procalcitonin (PCT) and C-reactive protein (CRP) are two acute-phase reactants with different clinical features. The study aimed to compare the diagnostic value of admission serum PCT and CRP concentrations as indicators of aetiology and intensity of inflammation in children hospitalized with diarrhoea. METHODS: Serum PCT and CRP concentrations were …
Incidence of inflammatory bowel disease is rising and abdominal tuberculosis is falling in Bangladeshis in East London, United Kingdom
Publication Year: 2004 Source: Am J Gastroenterol PMID: 15330914 DOI: 10.1111/j.1572-0241.2004.30445.x
1. Inflammatory bowel disease (IBD) is characterized by oxidative and nitrosative stress, leukocyte infiltration, and increased expression of the adhesion molecules intercellular adhesion molecule 1 (ICAM-1) in the colon. Recent evidence also suggests that the cyclopentenone prostaglandin (PG) 15-deoxy-delta(12,14)-PGJ(2) (15d- PGJ(2)) functions as an early anti-inflammatory signal. 2. The aim …
Pitfalls in the accurate measurement of joint space narrowing in semiflexed, anteroposterior radiographic imaging of the knee
Publication Year: 2004 Source: Arthritis Rheum PMID: 15334464 DOI: 10.1002/art.20363
Decay-accelerating factor (DAF or CD55) is expressed on colonic epithelial cells but its function in the mucosa is unknown. In humans, a proportion of DAF-deficient (Cromer INAB) patients develop inflammatory bowel disease (IBD). To evaluate how DAF deficiency may contribute to gut inflammation and thus could play a role in …
The role of substance P in inflammatory disease
Publication Year: 2004 Source: J Cell Physiol PMID: 15334652 DOI: 10.1002/jcp.20061
Several matrix metalloproteinases (MMPs) have been implicated in intestinal inflammation, mucosal wound healing, and cancer progression. The purpose of this study was to examine the cellular location and putative function of MMP-19, MMP-26 (matrilysin-2), and MMP-28 (epilysin), in normal, inflammatory, and malignant conditions of the intestine. Peroperative tissue specimens from …
The role of bacterial infection in the pathogenesis of inflammatory bowel disease
Publication Year: 2004 Source: Intern Med PMID: 15335176 DOI: 10.2169/internalmedicine.43.534
Inflammatory bowel disease may have a deleterious effect on bowel healing, but its role is difficult to demonstrate in clinical practice because of the association of multiple factors. An experiment was conducted in rats. They were divided into two groups: group I, a model of acetic acid induced colitis, and …
A pilot study of compassionate use of Levetiracetam in patients with generalised epilepsy
Publication Year: 2004 Source: J Clin Neurosci PMID: 15337134 DOI: 10.1016/j.jocn.2004.01.002
87Rb-MRI was used to measure Rb(+) uptake in blood-perfused pig hearts during complete occlusion (120 and 70 min) of the left anterior descending artery (LAD) and subsequent reperfusion (120 and 170 min). The Rb(+) uptake rate and maximal Rb image intensity during 120-min occlusion were significantly lower in the ischemic …
Questions on life satisfaction (FLZM) in inflammatory bowel disease
Publication Year: 2004 Source: Int J Colorectal Dis PMID: 14586630 DOI: 10.1007/s00384-003-0522-z
OBJECTIVE: ANCA (p-ANCA and x-ANCA) have been documented to occur in many inflammatory disorders. The specific ANCA antigens and the clinical correlation of a positive ANCA test in these disorders are still for the most part obscure. The aim of the present study was to investigate the prevalence of and …
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