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Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis
Publication Year: 2004 Source: Hum Mol Genet PMID: 14613970 DOI: 10.1093/hmg/ddh008
BACKGROUND: The insulin-like growth factor (IGF) axis consists of two IGFs and six IGF-binding proteins (IGFBPs) that regulate proliferation and differentiation of many cell types. Malnutrition and inflammation alter the IGF axis. The authors evaluated circulating IGFs and IGFBPs in patients with inflammatory bowel disease (IBD) at the time of …
Tumour necrosis factor-alpha converting enzyme (TACE) activity in human colonic epithelial cells
Publication Year: 2004 Source: Clin Exp Immunol PMID: 14678276 DOI: 10.1111/j.1365-2249.2004.02348.x
OBJECTIVES: The aims of this study were 1) to develop a valid method for the measurement of the eosinophil proteins eosinophil cationic protein (ECP) and eosinophil protein X (EPX) and neutrophil proteins myeloperoxidase and human neutrophil lipocalin (HNL) in feces and 2) to investigate their potential role as disease activity …
Ulcerative colitis associated enteritis: is ulcerative colitis always confined to the colon?
Publication Year: 2004 Source: J Clin Gastroenterol PMID: 14679327 DOI: 10.1097/00004836-200401000-00011
Direct identity-by-descent mapping is a technique for narrowing down the location of the gene or genes responsible for a given genetic disease to small segments of the genome. The technique involves DNA comparisons between pairs of affected individuals. The data generated are in the form of matching segments of the …
Chemokines in inflammatory bowel disease
Publication Year: 2004 Source: Curr Allergy Asthma Rep PMID: 14680627 DOI: 10.1007/s11882-004-0048-7
Osteoporosis is now recognized as a problem in children with chronic illness. Decreased bone mineral density and increased risk of fracture have been reported in children with inflammatory bowel disease (IBD). Recent studies have led to a better understanding of the pathogenesis of bone loss. There are many risk factors …
Mesalazine is safe for the treatment of IBD
Publication Year: 2004 Source: Gut PMID: 14684596 DOI: 10.1136/gut.53.1.155
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Venous thromboembolism in inflammatory bowel disease
Publication Year: 2004 Source: Am J Gastroenterol PMID: 14687149 DOI: 10.1046/j.1572-0241.2003.04026.x
Inflammatory bowel disease (IBD) is a group of chronic intestinal inflammatory diseases that consists of ulcerative colitis (UC), an inflammation of the large intestine, and Crohn's disease (CD), which can affect any part of the gastrointestinal tract. IBD affects approximately 1 in every 1000 individuals in western countries. There is …
Splitting irritable bowel syndrome: from original Rome to Rome II criteria
Publication Year: 2004 Source: Am J Gastroenterol PMID: 14687153 DOI: 10.1046/j.1572-0241.2003.04024.x
Previously we have conducted a genome-wide search for inflammatory bowel disease susceptibility loci in a large European cohort. Results from this study demonstrated suggestive evidence of linkage to loci at chromosomes 1q, 6p, and 10p and replicated linkages on chromosomes 12 and 16. Recently, NOD2/CARD15 on chromosome 16q12 has been …
Relationships between serum IGF-1, IGFBP-2, interleukin-1beta and interleukin-6 in inflammatory bowel disease
Publication Year: 2004 Source: Horm Res PMID: 14691340 DOI: 10.1159/000075699
BACKGROUND: Inflammatory bowel diseases (IBDs) are characterized by chronic intestinal inflammation as a result of an exaggerated T-cell response. CTLA4, a receptor of activated T cells, has an inhibitory function in regulating T-cell activation. Since CTLA4 gene polymorphisms have been associated with several autoimmune diseases, the aim was to study …
Tests for covariate-associated heterogeneity in IBD allele sharing of affected relatives
Publication Year: 2004 Source: Genet Epidemiol PMID: 14691956 DOI: 10.1002/gepi.10294
Crohn's disease (CD) is an idiopathic chronic inflammatory bowel disease (IBD). Accurate diagnosis of the disease is of great clinical importance to assess its prognosis and success of therapy. Recent studies have validated and confirmed the potential utility of anti-Saccharomyces cerevisiae (baker's yeast; ASCA) IgG/IgA antibodies and anti-M. avium ss. …
Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells
Publication Year: 2004 Source: J Biol Chem PMID: 14701802 DOI: 10.1074/jbc.M312757200
BACKGROUND & AIMS: Innate and adaptive immune responses are regulated by cross talk between activation and inhibitory signals. Dysregulation of the inhibitory signal can lead to aberrant chronic inflammatory diseases such as the inflammatory bowel diseases (IBD). Little is known about negative regulation of innate intestinal immune activation. We examined …
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