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Direct IBD mapping: identical-by-descent mapping without genotyping
Publication Year: 2004 Source: Genomics PMID: 14706463 DOI: 10.1016/j.ygeno.2003.08.002
Erratum in Br J Clin Pharmacol. 2003 Nov;56(5):584. The pathophysiology of inflammatory bowel disease (IBD) is gradually being unravelled and new therapies are being developed to target the disturbed biological processes. This article outlines the clinical features of IBD, its current therapy and pathogenesis. The difficulties for clinical pharmacologists and …
QTL detection and allelic effects for growth and fat traits in outbred pig populations
Publication Year: 2004 Source: Genet Sel Evol PMID: 14713411 DOI: 10.1186/1297-9686-36-1-83
Genetic predisposition has been suggested to play an important role in the pathogenesis of inflammatory bowel diseases (IBDs). Linkage studies have identified a Crohn's disease susceptibility locus on chromosome 14 (14q11-12; IBD4). Interleukin-25 (IL-25) is a newly identified proinflammatory cytokine that has been shown to promote Th2 responses by inducing …
Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1
Publication Year: 2004 Source: J Biol Chem PMID: 14722058 DOI: 10.1074/jbc.M312972200
IL-6 is a potent proinflammatory cytokine that has been shown to play an important role in the pathogenesis of inflammatory bowel disease (IBD). It is classically known to activate gene expression via the STAT-3 pathway. Given the crucial role of IL-6 in the pathogenesis of chronic intestinal inflammation, it is …
Hip fractures in patients with inflammatory bowel disease and their relationship to corticosteroid use: a population based cohort study
Publication Year: 2004 Source: Gut PMID: 14724159 DOI: 10.1136/gut.2003.026799
Inflammatory bowel disease (IBD) is associated with increased activation of intestinal immune cells, whose overproduction of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) is implicated in mediating the sustained inflammatory response. Studies to date have largely reported qualitative differences in cytokine gene expression between …
Inhibition of oxidant-induced nuclear factor-kappaB activation and inhibitory-kappaBalpha degradation and instability of F-actin cytoskeletal dynamics and barrier function by epidermal growth factor: key role of phospholipase-gamma isoform
Publication Year: 2004 Source: J Pharmacol Exp Ther PMID: 14724221 DOI: 10.1124/jpet.103.062232
BACKGROUND AND AIMS: Thiopurines represent the mainstay of immunosuppressive therapy in inflammatory bowel diseases. Since it is likely that response to therapy and adverse events depends on the genetic background of patients our study aimed to evaluate retrospectively response to therapy and safety in a mixed IBD population in Southern …
Cost of outpatient care in patients with inflammatory bowel disease in a German University Hospital
Publication Year: 2004 Source: J Gastroenterol Hepatol PMID: 14731130 DOI: 10.1111/j.1440-1746.2004.03251.x
The aim of this study was to compare, under different models of gene-environment (G x E) interaction, the power to detect linkage and G x E interaction of different tests using affected sib-pairs. Methods considered were: 1) the maximum likelihood lod-score (MLS), based on the distribution of parental alleles identical …
Imaging of intestinal lymphocyte homing by means of pinhole SPECT in a TNBS colitis mouse model
Publication Year: 2004 Source: Nucl Med Biol PMID: 14741574 DOI: 10.1016/s0969-8051(03)00109-4
BACKGROUND: Anti-Saccharomyces cerevisiae antibodies (ASCA) and perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) are serological markers associated, respectively, with Crohn's disease and ulcerative colitis, whose clinical significance and possible diagnostic role are still poorly defined. AIMS: (a) To evaluate the sensitivity, specificity and predictive values of isolated and combined ASCA and p-ANCA …
Impact of depressive mood on relapse in patients with inflammatory bowel disease: a prospective 18-month follow-up study
Publication Year: 2004 Source: Psychosom Med PMID: 14747641 DOI: 10.1097/01.psy.0000106907.24881.f2
Epstein-Barr virus (EBV) is associated with several lymphoid and epithelial human malignancies. The latter include gastric adenocarcinomas, while sporadic colorectal adenocarcinomas (CRCs) have been reported to be EBV-negative. Recently, increased numbers of EBV-infected B lymphocytes have been detected in intestinal mucosal samples affected by ulcerative colitis (UC) and, to a …
Analysis of the CARD15 variants R702W, G908R and L1007fs in Italian IBD patients
Publication Year: 2004 Source: Eur J Hum Genet PMID: 14747834 DOI: 10.1038/sj.ejhg.5201130
Linkage of IBD to the pericentromeric region of chromosome 16 has been widely confirmed by analyses of multiple populations. The NOD2 gene is located in the peak region of linkage on chromosome 16 and thought to be involved in the activation of nuclear factor (NF) kappaB in response to bacterial …
Conditional multipoint linkage analysis using affected sib pairs: an alternative approach
Publication Year: 2004 Source: Genet Epidemiol PMID: 14748010 DOI: 10.1002/gepi.10305
In commercial livestock populations, QTL detection methods often use existing half-sib family structures and ignore additional relationships within and between families. We reanalyzed the data from a large QTL confirmation experiment with 10 pig lines and 10 chromosome regions using identity-by-descent (IBD) scores and variance component analyses. The IBD scores …
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