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Structures of isobutyryl-CoA dehydrogenase and enzyme-product complex: comparison with isovaleryl- and short-chain acyl-CoA dehydrogenases
Publication Year: 2004 Source: J Biol Chem PMID: 14752098 DOI: 10.1074/jbc.M400034200
BACKGROUND: Patients with inflammatory bowel disease (IBD) have an increased incidence of thromboembolic events. This risk may be caused by an increased frequency of thrombophilic mutations such as factor V Leiden G1691A (FVL), prothrombin G20210A (PT), or methylene tetrahydrofolate reductase C667T (MTHFR). Prevalence rates of heterozygous mutations in FVL, PT, …
Social learning, affective state and passive coping in irritable bowel syndrome and inflammatory bowel disease
Publication Year: 2004 Source: Gen Hosp Psychiatry PMID: 14757303 DOI: 10.1016/j.genhosppsych.2003.07.005
Recently, Liang et al. ([2001b] Genet. Epidemiol. 21:105-122) proposed a conditional approach to assess linkage evidence on the target region by incorporating linkage information from an unlinked (reference) region using allele shared IBD (identity-by-decent) from affected sib pairs. This is carried out by conditioning on the IBD sharing value at …
Key role of mast cells and their major secretory products in inflammatory bowel disease
Publication Year: 2004 Source: World J Gastroenterol PMID: 14760748 DOI: 10.3748/wjg.v10.i3.309
Colorectal cancer is the most common malignant complication in patients who have IBD. The disease is difficult to diagnose because there is an overlap in symptoms in patients who have colon cancer and those who have IBD. Much has been learned about the incidence of colorectal cancer in patients who …
Striking elevation in incidence and prevalence of inflammatory bowel disease in a province of western Hungary between 1977-2001
Publication Year: 2004 Source: World J Gastroenterol PMID: 14760767 DOI: 10.3748/wjg.v10.i3.404
BACKGROUND: Iron-deficiency anemia is a frequent complication in children with inflammatory bowel disease (IBD). Parenteral iron therapy is rarely prescribed because of concern about potential side effects. The aim of this study was to retrospectively evaluate the safety and efficacy of total dose intravenous (TDI) iron therapy. METHODS: Charts of …
IBD researchers reach for the "tabloid"
Publication Year: 2004 Source: Gastroenterology PMID: 14762801 DOI: 10.1053/j.gastro.2003.09.045
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Genetics of inflammatory bowel disease: progress and prospects
Publication Year: 2004 Source: Hum Mol Genet PMID: 14764625 DOI: 10.1093/hmg/ddh079
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The frame-shift mutation of the NOD2/CARD15 gene is significantly increased in ulcerative colitis: an *IG-IBD study
Publication Year: 2004 Source: Gastroenterology PMID: 14765396 DOI: 10.1053/j.gastro.2003.12.027
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Assessing whether an allele can account in part for a linkage signal: the Genotype-IBD Sharing Test (GIST)
Publication Year: 2004 Source: Am J Hum Genet PMID: 14872409 DOI: 10.1086/381712
The intestinal flora play an important role in experimental colitis and inflammatory bowel disease (IBD). Using colonic explant cultures from 132 IBD and control subjects, we examined tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 and interleukin-1 receptor antagonist (IL-1RA) production in vitro in response to bacterial activators. Unstimulated TNF-alpha release was …
Intestinal motor disorders associated with cyclical bacterial overgrowth in a rat model of enteritis
Publication Year: 2004 Source: Am J Physiol Gastrointest Liver Physiol PMID: 14962848 DOI: 10.1152/ajpgi.00513.2003
Human recombinant interleukin 11 (rhIL-11) is a cytokine that suppresses the clinical signs of colitis in animal models of inflammatory bowel disease (IBD) and may be an effective therapeutic agent in the treatment of IBD. The objective of the current study was to investigate whether rhIL-11 was capable of reversing …
Validation of the inflammatory bowel disease questionnaire IBDQ-D, German version, for patients with ileal pouch anal anastomosis for ulcerative colitis
Publication Year: 2004 Source: Z Gastroenterol PMID: 14963785 DOI: 10.1055/s-2004-812835
BACKGROUND AND AIM: Primary sclerosing cholangitis (PSC) is a rare chronic disease in Singapore and its epidemiological profile has not been described previously. The present study aimed to define the demographic and clinical profile of patients with PSC in Singapore. METHODS: The case records of patients with PSC seen at …
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