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Hepatocyte growth factor treatment ameliorates diarrhea and bowel inflammation in a rat model of inflammatory bowel disease
Publication Year: 2004 Source: J Pediatr Surg PMID: 14966727 DOI: 10.1016/j.jpedsurg.2003.10.001
Comment in Can J Gastroenterol. 2004 Jun;18(6):407-8; discussion 408. Gastroenterology. 2004 Sep;127(3):1001-2; discussion 1002. OBJECTIVES: There is increased interest in determining whether 5-aminosalicylate (5-ASA) use can prevent the development of colorectal cancer (CRC) among patients with inflammatory bowel disease (IBD). The aim of this study was to determine whether use …
Tumor necrosis factor-alpha antibody for induction of remission in Crohn's disease
Publication Year: 2004 Source: Cochrane Database Syst Rev PMID: 14974022 DOI: 10.1002/14651858.CD003574.pub2
Update in Cochrane Database Syst Rev. 2006;(2):CD000544. Update of Cochrane Database Syst Rev. 2000;(2):CD000544. BACKGROUND: The newer 5-ASA preparations were intended to avoid the adverse effects of SASP while maintaining its therapeutic benefits. The efficacy and safety of 5-ASA preparations have been evaluated in numerous clinical trials that have often …
Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs
Publication Year: 2004 Source: Hum Mol Genet PMID: 14976156 DOI: 10.1093/hmg/ddh090
BACKGROUND: The Inflammatory Bowel Disease Questionnaire (IBDQ) is a disease-specific health-related quality of life (HRQOL) questionnaire including four dimensions and a sum score. The aim of this study was to assess the internal and external validity, reliability, and sensitivity of a Swedish version of the IBDQ. METHODS: Three hundred consecutive …
Colonic leptin: source of a novel proinflammatory cytokine involved in IBD
Publication Year: 2004 Source: FASEB J PMID: 14977884 DOI: 10.1096/fj.03-0422fje
BACKGROUND: Colorectal cancer is the third most common cancer in Sweden, and incidence is increasing. We analysed colorectal cancer detection by colonoscopy in a defined population in Sweden. METHODS: All colonoscopy records for the period 1979-95 in one Swedish county (population 258,000) were retrieved. Information was obtained about patient demographics, …
Interferon gamma downregulates IL-8 production in primary human colonic epithelial cells without induction of apoptosis
Publication Year: 2004 Source: Int J Colorectal Dis PMID: 14986030 DOI: 10.1007/s00384-003-0570-4
BACKGROUND & AIMS: There is renewed interest in commensal bacteria as triggers of idiopathic disease, a concept that is prominent in inflammatory bowel disease (IBD). Here the effect of intracolonic instillation of Staphylococcus aureus enterotoxin B (SEB), a model superantigen (SAgs: potent T-cell stimuli), into mice was examined. METHODS: Mice …
Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease
Publication Year: 2004 Source: Gastroenterology PMID: 14988837 DOI: 10.1053/j.gastro.2003.12.011
BACKGROUND: Interleukin 1beta (IL-1beta) and its natural antagonist have been implicated in the pathogenesis of inflammatory bowel disease (IBD). Both cytokines influence bone formation. IL-1beta stimulates osteoclast activity while interleukin 1 receptor antagonist (IL-1ra) enhances bone formation. AIMS: To determine whether the decreased bone mass in IBD is related to …
Renal impairment in patients with inflammatory bowel disease: association with aminosalicylate therapy?
Publication Year: 2004 Source: Clin Nephrol PMID: 14989626 DOI: 10.5414/cnp61083
OBJECTIVES: Clinicians are becoming increasingly aware that inflammatory bowel disease (IBD) can affect all age groups, although it has not been well described in infants and young children. Our aim was to evaluate early onset IBD in patients 5 yr of age and younger. METHODS: Medical records of patients diagnosed …
IL-10 and its related cytokines for treatment of inflammatory bowel disease
Publication Year: 2004 Source: World J Gastroenterol PMID: 14991925 DOI: 10.3748/wjg.v10.i5.620
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Peripheral blood mononuclear cell DNA 6-thioguanine metabolite levels correlate with decreased interferon-gamma production in patients with Crohn's disease on AZA therapy
Publication Year: 2004 Source: Dig Dis Sci PMID: 14992447 DOI: 10.1023/b:ddas.0000011614.88494.ee
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Increased expression of CCL20 in human inflammatory bowel disease
Publication Year: 2004 Source: J Clin Immunol PMID: 14997037 DOI: 10.1023/B:JOCI.0000018066.46279.6b
Comment in Gastroenterology. 1995 Jan;108(1):284-6. BACKGROUND/AIMS: In inflammatory bowel disease (IBD), peripheral monocytes and intestinal macrophages show an increased state of priming and activation. The aim of this study was to test the hypothesis that the response of IBD mononuclear phagocytes to the contrainflammatory cytokine interleukin (IL) 4 may be …
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