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[Chronic inflammatory bowel diseases competence network ]
Publication Year: 2004 Source: Internist (Berl) PMID: 14999384 DOI: 10.1007/s00108-004-1158-y
OBJECTIVE: Lactoferrin is a glycoprotein expressed by activated neutrophils. The aim of this study was to determine the sensitivity and specificity of fecal lactoferrin concentrations for inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS) versus healthy controls. METHODS: Fresh stool samples were collected from outpatients with ulcerative colitis (UC), …
Bone mineral density in patients with inflammatory bowel disease: a population-based prospective two-year follow-up study
Publication Year: 2004 Source: Scand J Gastroenterol PMID: 15000276 DOI: 10.1080/00365520310007873
OBJECTIVE: 6-Mercaptopurine (6-MP) and azathioprine (AZA) have proven efficacy in the treatment of inflammatory bowel disease (IBD). However, adverse events leading to discontinuation may occur in 10-20% of patients. The efficacy of AZA and 6-MP is based on formation of their active metabolites, the 6-thioguaninenucleotides (6-TGNs). Therefore, 6-thioguanine (6-TG), an …
CYP450 dietary inhibitors attenuate TNF-alpha-stimulated endothelial molecule expression and leukocyte adhesion
Publication Year: 2004 Source: Am J Physiol Cell Physiol PMID: 15001427 DOI: 10.1152/ajpcell.00351.2003
Prolonged antigenic stimulation results in lymphocyte shedding of CD27, a member of the tumour necrosis factor receptor (TNFR) family, and transformation to a stable phenotype capable of synthesizing interleukin-4 (IL-4). Co-expression of alpha4beta7 identifies those cells with gut-homing potential. We have investigated these cell populations in patients with inflammatory colonic …
Population-based case control study of seroprevalence of Mycobacterium paratuberculosis in patients with Crohn's disease and ulcerative colitis
Publication Year: 2004 Source: J Clin Microbiol PMID: 15004064 DOI: 10.1128/JCM.42.3.1129-1135.2004
BACKGROUND: Bone loss and osteoporosis are commonly reported in inflammatory bowel disease (IBD), especially Crohn disease (CD). The aims of the present study were to evaluate changes in bone mineral density (BMD) in IBD patients during a 2-year follow-up period, and to investigate the role played by possible contributing factors …
Suppression of CD4+ T lymphocyte effector functions by CD4+CD25+ cells in vivo
Publication Year: 2004 Source: J Immunol PMID: 15004137 DOI: 10.4049/jimmunol.172.6.3391
OBJECTIVES: The aetiology of primary sclerosing cholangitis (PSC) is unknown, and the role of micro-organisms has been studied only to a limited extent. We tested the hypothesis that past or persisting infection with common viruses or atypical bacteria might play a role in genetically susceptible hosts. DESIGN: Case-control study. METHODS: …
Decay-accelerating factor deficiency increases susceptibility to dextran sulfate sodium-induced colitis: role for complement in inflammatory bowel disease
Publication Year: 2004 Source: J Immunol PMID: 15004190 DOI: 10.4049/jimmunol.172.6.3836
OBJECTIVE: To obtain information on the clinical experience with azathioprine (AZA), 6-mercaptopurine (6-MP), cyclosporin A (CyA) and methotrexate (MTX) in the treatment of patients with inflammatory bowel disease (IBD) by gastroenterologists and internists in different countries. DESIGN: A questionnaire designed by the International Organization for the Study of Inflammatory Bowel …
Chronic inflammation, apoptosis and (pre-)malignant lesions in the gastro-intestinal tract
Publication Year: 2004 Source: Apoptosis PMID: 15004509 DOI: 10.1023/B:APPT.0000018794.26438.22
Ulcerative colitis (UC) and Crohn's disease (CD) are heterogeneous disorders characterized by chronic intestinal inflammation. Genetic predisposition is a major risk factor in both diseases. The CARD15 (NOD2) gene has been implied as a candidate gene in the pathogenesis CD. Our aim was to delineate the frequency of three missense …
Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders
Publication Year: 2004 Source: Springer Semin Immunopathol PMID: 15007629 DOI: 10.1007/s00281-003-0148-9
Toxic megacolon (TM) is an infrequent but devastating complication of colitis. Numerous forms of colonic inflammation can give rise to TM but the majority occur in individuals with inflammatory bowel disease (IBD). Recently there has been a marked increase in the number of reports of TM associated with pseudomembranous colitis. …
Increased expression of minichromosome maintenance protein 2 in active inflammatory bowel disease
Publication Year: 2004 Source: Colorectal Dis PMID: 15008907 DOI: 10.1111/j.1463-1318.2004.00567.x
Mucosal changes in inflammatory bowel disease (IBD) are characterized by ulcerative lesions accompanied by prominent cellular infiltrates in the bowel wall. Chemokines are chemotactic cytokines that are able to promote leukocyte migration to areas of inflammation and are also able to initiate cell activation events. They have recently been implicated …
Anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease are associated with disease severity but not NOD2/CARD15 mutations
Publication Year: 2004 Source: Clin Exp Immunol PMID: 15008984 DOI: 10.1111/j.1365-2249.2003.02392.x
Crohn's disease and ulcerative colitis (the inflammatory bowel diseases) have a strong genetic component. Although over 20 putative susceptibility loci have been identified by individual genome scans, the majority of these loci have not been replicated. Many individual studies are at the lower limit of acceptable power for complex disease …
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