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Defining complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes
Publication Year: 2003 Source: Inflamm Bowel Dis PMID: 14555911 DOI: 10.1097/00054725-200309000-00001
Small bowel epithelium is at the frontline of intestinal barrier function. Restitution is considered to be the major determinant of epithelial repair, because function recovers in parallel with restitution after acute injury. As such, studies of intact mucosa have largely been replaced by migration assays of cultured epithelia. These latter …
Oral iron therapy in inflammatory bowel disease: usage, tolerance, and efficacy
Publication Year: 2003 Source: Inflamm Bowel Dis PMID: 14555915 DOI: 10.1097/00054725-200309000-00005
BACKGROUND: Incidences of inflammatory bowel disease (IBD) and of breast cancer have increased over the last decades. The influence of IBD on breast cancer prognosis, however, is unknown. We therefore examined the impact of IBD on treatment receipt and survival in breast cancer patients. METHODS: Information on breast cancer patients …
Familial occurrence of inflammatory bowel disease in celiac disease
Publication Year: 2003 Source: Inflamm Bowel Dis PMID: 14555916 DOI: 10.1097/00054725-200309000-00006
OBJECTIVE: Thromboembolic events are serious complications in patients with inflammatory bowel disease (IBD). Resistance of factor V to degradation by activated protein C (APC) is a major cause for venous thrombosis and is found in approximately 30% of patients with thromboembolism. The aim of the present study was to assess …
Anti-TNF-alpha antibody normalizes serum leptin in IL-2 deficient mice
Publication Year: 2003 Source: J Am Coll Nutr PMID: 14559934 DOI: 10.1080/07315724.2003.10719325
Mucosal tissue damage in chronic inflammatory bowel disease (IBD) is partly caused by an enduring exposure to excessive amounts of reactive oxygen metabolites (ROM). To protect themselves from the toxic effects of ROM, most intestinal cell types constitutively express the highly specific, key ROM-neutralizing cytosolic enzyme Cu/Zn-superoxide dismutase (SOD). Under …
Cytokine network in inflammatory bowel disease
Publication Year: 2003 Source: Curr Drug Targets Inflamm Allergy PMID: 14561161 DOI: 10.2174/1568010033484197
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Probiotics and immune regulation of inflammatory bowel diseases
Publication Year: 2003 Source: Curr Drug Targets Inflamm Allergy PMID: 14561167 DOI: 10.2174/1568010033484278
We consider idealized gamete identity by descent (IBD) data which consists of the lengths of IBD and non-IBD regions along the genome for gametes segregating from two related individuals. Information on the relationship between the individuals is contained in the pattern of lengths, with the power of the likelihood ratio …
Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: results of a 25-year follow-up study
Publication Year: 2003 Source: World J Gastroenterol PMID: 14562397 DOI: 10.3748/wjg.v9.i10.2300
Comment in Inflamm Bowel Dis. 2001 Aug;7(3):190-1. BACKGROUND AND AIMS: A substantial number of patients with inflammatory bowel disease (IBD) fail to achieve a complete clinical response with 6-mercaptopurine (6-MP) and azathioprine (AZA). Inability to achieve therapeutic 6-thioguanine nucleotide (6-TGN) levels due to the preferential overproduction of 6-methylmercaptopurine ribonucleotides (6-MMPR) …
Inflammatory bowel disease in early childhood and adolescence: special considerations
Publication Year: 2003 Source: Gastroenterol Clin North Am PMID: 14562584 DOI: 10.1016/s0889-8553(03)00046-3
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Colorectal cancer and high grade dysplasia complicating ulcerative colitis in Italy. A retrospective co-operative IG-IBD study
Publication Year: 2003 Source: Dig Liver Dis PMID: 14563184 DOI: 10.1016/s1590-8658(03)00380-3
OBJECTIVE: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) of unknown etiology frequently requiring long-term therapy for control of symptoms and prevention of relapse. Azathioprine (AZA) has been shown to be effective and safe in the treatment of chronic active UC. However, the alternatives to treatment with AZA are …
A genome-wide scan for loci affecting normal adult height in the Framingham Heart Study
Publication Year: 2003 Source: Hum Hered PMID: 14566097 DOI: 10.1159/000073203
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