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Gallic acid serves as an effective therapeutic agent of inflammatory bowel disease: Pharmacological impacts on tight junction-dependent intestinal permeability in vivo and its related intracellular signaling
Publication Year: 2025 Source: Curr Res Pharmacol Drug Discov PMID: 40492109 DOI: 10.1016/j.crphar.2025.100223
Intestinal tight junction disruption contributes to the pathogenesis of inflammatory bowel diseases (IBD). We have recently reported that gallic acid was able to enhance intestinal tight junction assembly via CaMKK-beta/AMPK/SIRT-1/ERK-dependent mechanisms with unknown possible therapeutic applications in IBD. The main aims of this study are to investigate the in vivo …
Offspring exposure to Crohn's disease during pregnancy and association with milder psychiatric regulatory disturbances in childhood
Publication Year: 2025 Source: Acta Obstet Gynecol Scand PMID: 40492456 DOI: 10.1111/aogs.15167
INTRODUCTION: Prenatal exposure to inflammatory states has been suggested to influence offspring neurodevelopment. The aim was to investigate if offspring exposure to maternal Inflammatory bowel disorder (IBD), or specifically the IBD disorder Crohn's disease, during gestation is associated with neurodevelopmental or psychiatric disorders in childhood. MATERIAL AND METHODS: We conducted …
Direct Modulation of Host Cells and Gut Microbiota by Orally Delivered Antioxidant Nanocages for Colitis Treatment
Publication Year: 2025 Source: ACS Nano PMID: 40493472
Ulcerative colitis (UC) involves a complex interplay of mucosal inflammation, intestinal barrier dysfunction, and gut dysbiosis, all exacerbated by elevated reactive oxygen species (ROS). Existing therapies often fail to concurrently address these interrelated pathologies. Here we present an orally administrable nanocage system that targets both host cells and gut microbiota …
Biomaterial-based therapeutic strategies for inflammatory bowel disease
Publication Year: 2025 Source: Biomaterials PMID: 40494022 DOI: 10.1016/j.biomaterials.2025.123462
Inflammatory bowel disease (IBD) is a chronic, challenging condition characterized by epithelial barrier disruption, immune dysregulation, and alterations in gut microbiota, leading to symptoms such as abdominal pain, diarrhea, and weight loss, affecting millions of patients worldwide. The etiology and pathogenesis of IBD are multifactorial, involving a combination of genetic …
Erratum to "Safety and immunogenicity of the measles-mumps-rubella vaccine in immunocompromised children with inflammatory bowel disease, or after liver transplantation: An observational study" [Vaccine 59 (2025) 127288]
Publication Year: 2025 Source: Vaccine PMID: 40494227
No Abstract
3D-printed Laponite/alginate hydrogel-based suppositories as innovative platforms for AT-MSC secretome delivery in IBD treatment
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40494478 DOI: 10.1016/j.ijbiomac.2025.145104
The secretome of Mesenchymal Stromal Cells (MSCs) has demonstrated effectiveness in the treatment of Inflammatory Bowel Disease (IBD), offering a safer and more predictable alternative to the direct administration of MSCs. While parenteral administration is common, rectal delivery of the secretome provides targeted treatment for localized conditions such as ulcerative …
Endoscopic assessment and scoring in pediatric inflammatory bowel disease: A consensus from SIGENP
Publication Year: 2025 Source: Dig Liver Dis PMID: 40494721 DOI: 10.1016/j.dld.2025.05.020
Mucosal healing is the main treatment goal in the management of pediatric inflammatory bowel diseases (IBD), and accurate endoscopic assessment is essential for evaluating disease severity, monitoring progression, and assessing therapeutic responses. However, the wide variability of mucosal lesions, combined with the lack of standardized guidelines and limited training opportunities, …
Mitsugumin 53 drives stem cell differentiation easing intestinal injury and inflammation
Publication Year: 2025 Source: Signal Transduct Target Ther PMID: 40494851 DOI: 10.1038/s41392-025-02268-x
Emerging evidence suggests that priming intestinal stem cells (ISCs) towards secretory progenitor cells is beneficial for maintaining gut homeostasis against inflammatory bowel disease (IBD). However, the mechanism driving such biased lineage commitment remains elusive. Here we show that MG53, also named as TRIM72, prompts ISCs to secretory lineages via upregulating …
Histological features of very early-onset compared to later-onset inflammatory bowel diseases: A multicenter retrospective study
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40495584 DOI: 10.1002/jpn3.70110
OBJECTIVES: To identify and describe endoscopic and histological features of children with non-monogenic very early-onset inflammatory bowel diseases (VEO-IBD) compared to endoscopic and histological features of children with later-onset (LO-IBD). METHODS: A multicenter retrospective observational study in two Italian Pediatric IBD referral centers was done. Patients with VEO-IBD were matched …
Advancing large language models as patient education tools for inflammatory bowel disease
Publication Year: 2025 Source: World J Gastroenterol PMID: 40495941
This article evaluates the transformative potential of large language models (LLMs) as patient education tools for managing inflammatory bowel disease. The discussion highlights their ability to deliver nuanced and personalized information, addressing limitations in traditional educational materials. Key considerations include the necessity for domain-specific fine-tuning to enhance accuracy, the adoption …
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