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Inflammatory bowel disease (IBD)
Publication Year: 2003 Source: Nursing PMID: 14597818 DOI: 10.1097/00152193-200311000-00045
Erratum in J Crohns Colitis. 2022 Aug 16;: Comment in J Crohns Colitis. 2022 Jan 24;: BACKGROUND: Olfactomedin-4 (OLFM4) is a glycoprotein characteristic of intestinal stem cells and apparently involved in mucosal defense of the stomach and colon. Here we studied its expression, regulation and function in IBD. METHODS: The …
Recent advances in the diagnosis and classification of inflammatory bowel disease
Publication Year: 2003 Source: Curr Gastroenterol Rep PMID: 14602059 DOI: 10.1007/s11894-003-0039-1
Recently, a number of experimental models of human inflammatory bowel disease (IBD) of immunological basis have been developed. These have proven useful tools in the study of IBD, allowing a more detailed dissection of the pathogenesis of the disease. Studies from these models have revealed new, important knowledge about environmental …
Optimizing immunomodulator therapy for inflammatory bowel disease
Publication Year: 2003 Source: Curr Gastroenterol Rep PMID: 14602061 DOI: 10.1007/s11894-003-0041-7
The importance of colorectal biopsies in the diagnosis and management of inflammatory bowel disease (IBD) is reviewed and the histologic criteria for identifying the different types of colitis are outlined. While most of the histopathologic features of the various forms of colitis are characteristic, none is pathognomonic. Accordingly, emphasis is …
Extraintestinal complications of inflammatory bowel disease
Publication Year: 2003 Source: Curr Gastroenterol Rep PMID: 14602062 DOI: 10.1007/s11894-003-0042-6
Comment in J Clin Gastroenterol. 2001 Jan;32(1):5. Compliance with medications is very important in the management of many gastrointestinal disorders: in inflammatory bowel disease (IBD), controlled trials have shown the benefit of prophylactic medical treatment in lowering the risk of recurrences. Our aim was to appraise the association between current …
Future therapies for inflammatory bowel disease
Publication Year: 2003 Source: Curr Gastroenterol Rep PMID: 14602063 DOI: 10.1007/s11894-003-0043-5
The Inflammatory Bowel Disease International Genetic Consortium was formed in Oxford in 1997. Since then it has grown to include twelve groups from around the world that are each actively involved in identifying the genes that are involved in susceptibility to IBD. The approach of the IBDIGC is to attempt …
MDR1 Ala893 polymorphism is associated with inflammatory bowel disease
Publication Year: 2003 Source: Am J Hum Genet PMID: 14610718 DOI: 10.1086/379927
BACKGROUND: In inflammatory bowel disease (IBD), gut inflammation is associated with the activation of nuclear factor kappa B (NF-κB), a key pro-inflammatory transcription factor. AIM: To investigate the therapeutic potential of a novel, specific NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), we examined its effect on IBD using murine experimental colitis models. METHODS: …
Variations in initial assessment and management of inflammatory bowel disease across Great Britain and Ireland
Publication Year: 2003 Source: Arch Dis Child PMID: 14612365 DOI: 10.1136/adc.88.11.990
Germ-free interleukin-10 knockout (IL-10 KO) mice developed inflammatory bowel disease (IBD) after they were colonized with a pure culture of Enterococcus faecalis. E. faecalis not only induced IBD (primarily in colon and rectum) but rectal dysplasia and adenocarcinoma was also found in the IL-10 KO mice. Conventional (complex-intestinal flora) IL-10 …
Presenting features of inflammatory bowel disease in Great Britain and Ireland
Publication Year: 2003 Source: Arch Dis Child PMID: 14612366 DOI: 10.1136/adc.88.11.995
OBJECTIVES: As inflammatory bowel disease is a chronic disorder, usually with an early onset in life, quality of care plays an important role for patients. The aim of this study was to develop a questionnaire to measure quality of care through the eyes of patients with inflammatory bowel disease. METHODS: …
Linoleic acid, but not oleic acid, upregulates the production of interleukin-8 by human intestinal smooth muscle cells isolated from patients with Crohn's disease
Publication Year: 2003 Source: Clin Nutr PMID: 14613754 DOI: 10.1016/s0261-5614(03)00083-9
beta7 Integrins have been shown to have an important role in the localization of T cells to the intestine. Utilizing two different experimental mouse models of inflammatory bowel disease (IBD), this study was undertaken to determine if beta7 integrin expression is critical for T cell localization to the intestine and …
Heterogeneity in IBD allele sharing among covariate-defined subgroups: issues and findings for affected relatives
Publication Year: 2003 Source: Hum Hered PMID: 14614243 DOI: 10.1159/000073737
Inflammatory bowel disease (IBD) has an impact on the quality of life of women regarding partner relationships and sexual health. Partner relationship and sexual health in women with IBD has been targeted minimally for investigation in the literature devoted to psychological, relationship, and sexual functioning. The purpose of the present …
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