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Association between K469E allele of intercellular adhesion molecule 1 gene and inflammatory bowel disease in a Japanese population
Publication Year: 2003 Source: Gut PMID: 12477764 DOI: 10.1136/gut.52.1.75
OBJECTIVES: Confronted with nonspecific symptoms, accurate screening tests would be useful to clinicians to distinguish between functional childhood disorders and inflammatory bowel disease (IBD), thus avoiding invasive diagnostic testing. Traditional ulcerative colitis-specific perinuclear antineutrophil cytoplasmic antibody (pANCA) and Crohn's disease-specific anti-Saccharomyces cerevisiae antibody (ASCA) serodiagnostic assays have recently been modified, …
Interacting genetic loci on chromosomes 20 and 10 influence extreme human obesity
Publication Year: 2003 Source: Am J Hum Genet PMID: 12478478 DOI: 10.1086/345648
The relatively recent development of genetically engineered agents has the potential to alter the treatment of Crohn's disease radically, and drugs that inhibit tumor necrosis factor-alpha (TNFalpha) have been introduced as a new therapeutic class with high efficacy, rapid onset of action, prolonged effect, and improved tolerance. However these agents …
PCR detection of Bifidobacterium strains and Streptococcus thermophilus in feces of human subjects after oral bacteriotherapy and yogurt consumption
Publication Year: 2003 Source: Int J Food Microbiol PMID: 12485746 DOI: 10.1016/s0168-1605(02)00245-3
Chronic ulcerative colitis (CUC) is an inflammatory destructive disease of the large intestine characterized by motility and secretion disorders. In the past decade, attention has been paid to the role of neuronal structures and mast cells in regulating inflammatory and immune responses in inflammatory bowel disease (IBD). The present study …
Possible protective effect of 5-aminosalicylic acid on Helicobacter pylori infection in patients with inflammatory bowel disease
Publication Year: 2003 Source: J Clin Gastroenterol PMID: 12488702 DOI: 10.1097/00004836-200301000-00008
Inflammatory bowel disease (IBD) is most common in young adults, but it can also present in the elderly. Furthermore, with the aging of the population, the number of elderly patients with IBD is expected to grow. Other conditions, such as diverticulitis and ischaemic colitis, may be more common in the …
The immunohistochemical expression of metallothionein in inflammatory bowel disease. Correlation with HLA-DR antigen expression, lymphocyte subpopulations and proliferation-associated indices
Publication Year: 2003 Source: Histol Histopathol PMID: 12507286 DOI: 10.14670/HH-18.75
Streptococcus thermophilus, Bifidobacterium infantis Y1 and Bifidobacterium breve Y8 strains were identified and enumerated by PCR assay in human fecal samples after intake of the pharmaceutical preparation VSL-3 or yogurt. ThI/ThII primer set, specific for S. thermophilus, was selected testing its specificity against several strains of enterococci, streptococci and other …
Imaging of ischemia and infarction in blood-perfused pig hearts using 87Rb MRI
Publication Year: 2003 Source: Magn Reson Med PMID: 12509824 DOI: 10.1002/mrm.10338
The study compared the effects of regional hypoxia and acidosis on Rb(+) uptake and energetics in isolated pig hearts perfused by the Langendorff method. The left anterior descending artery (LAD) was cannulated and the LAD bed was perfused with the same specific flow as the whole heart. Following equilibration with …
The safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study
Publication Year: 2003 Source: Gastroenterology PMID: 12512024 DOI: 10.1053/gast.2003.50014
Carbamazepine, a widely used anticonvulsant, can induce hepatotoxicity, usually evolving with an acute hepatitis that ceases after drug withdrawal. Carbamazepine-induced vanishing bile duct syndrome (VBDS) is a rare complication and has seldom been reported in the medical literature. This report presents a case of a 26-year-old male who had onset …
Inflammatory bowel disease in pregnancy
Publication Year: 2003 Source: Gut PMID: 12524388 DOI: 10.1136/gut.52.2.159
BACKGROUND: Inflammatory bowel diseases (IBD) are multifactorial disorders, characterized by failure to limit the inflammatory response to luminal antigens. Although genetic factors play an important role in the pathogenesis, little is known about the genes accountable. Immune response to intestinal bacteria seems to be crucial in the pathogenesis of IBD. …
Azathioprine and anti-TNF alpha therapies in Crohn's disease: a review of pharmacology, clinical efficacy and safety
Publication Year: 2003 Source: Pharmacol Res PMID: 12526855 DOI: 10.1016/s1043-6618(02)00264-5
Data with varying age at disease onset arise frequently in studies of mapping disease associated genes. Naively combining affected subjects with different ages at onset may result in a much reduced power in detecting the disease genes. In this paper we present a weighted score test statistic to detect the …
Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12526945 DOI: 10.1111/j.1572-0241.2003.07160.x
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