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DNA vaccination with plasmids containing various fragments of large segment genome of infectious bursal disease virus
Publication Year: 2003 Source: Vaccine PMID: 12531650 DOI: 10.1016/s0264-410x(02)00473-5
There is a close relationship between inflammatory bowel disease (IBD) and various hepatobiliary disorders. The objective of this study was to determine whether hepatic leukocyte recruitment occurs in experimental colitis. We used the murine model of colitis induced by 2,4-dinitrobenezenesulfonic acid (DNBS). Male C57Bl/6 mice received an intrarectal injection of …
Methotrexate for induction of remission in refractory Crohn's disease
Publication Year: 2003 Source: Cochrane Database Syst Rev PMID: 12535475 DOI: 10.1002/14651858.CD003459
The clinical benefit of Cyclosporine A (CsA) in IBD is controversial. Drugs including CsA are substrates of the P-glycoprotein-170 (Pgp-170) cell surface pump. Although the mechanism of action of CsA is complex, we determined that Pgp-170 might be expressed differentially between these two diseases. Intra-epithelial, lamina propria and peripheral blood …
The impact of helical computed tomography on the diagnosis of unsuspected inflammatory bowel disease in the large bowel
Publication Year: 2003 Source: Eur Radiol PMID: 12541117 DOI: 10.1007/s00330-002-1415-1
Inflammatory bowel disease (IBD) is known to influence physical, psychological, familial and social dimensions of life. Over the past two decades, attention has been focused on the ability of IBD to alter patients' quality of life. A number of general and disease-specific scales have been used to assess quality of …
Use of probiotics in the treatment of inflammatory bowel disease
Publication Year: 2003 Source: J Clin Gastroenterol PMID: 12544192 DOI: 10.1097/00004836-200302000-00005
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Immunohistochemical study of intestinal eosinophils in inflammatory bowel disease
Publication Year: 2003 Source: J Clin Gastroenterol PMID: 12544193 DOI: 10.1097/00004836-200302000-00006
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6-Thioguanine seems promising in azathioprine- or 6-mercaptopurine-intolerant inflammatory bowel disease patients: a short-term safety assessment
Publication Year: 2003 Source: Eur J Gastroenterol Hepatol PMID: 12544696 DOI: 10.1097/00042737-200301000-00011
Comment in J Gastroenterol Hepatol. 2002 Mar;17(3):233-5. BACKGROUND AND AIM: Thalidomide is clinically effective in the treatment of graft versus host disease in bone marrow transplantation and aphthous ulceration in HIV infection. It appears to exert a selective effect on tumor necrosis factor-alpha (TNF-alpha) production. Tumor necrosis factor-alpha is implicated …
The insulin-like growth factor axis in children with inflammatory bowel disease
Publication Year: 2003 Source: J Pediatr Gastroenterol Nutr PMID: 12548059 DOI: 10.1097/00005176-200302000-00014
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Plasma levels of soluble CD40 ligand are elevated in inflammatory bowel diseases
Publication Year: 2003 Source: Int J Colorectal Dis PMID: 12548417 DOI: 10.1007/s00384-002-0425-4
Calreticulin (CRT), a high-affintiy calcium binding protein and chaperone, was recently identified as one of the targets of autoantibodies in coeliac disease. We evaluated the level of IgA and IgG antibodies to CRT in sera from patients with coeliac disease and various autoimmune diseases. The level of antibodies to gliadin …
Multivariate and multilocus variance components method, based on structural relationships to assess quantitative trait linkage via SEGPATH
Publication Year: 2003 Source: Genet Epidemiol PMID: 12548674 DOI: 10.1002/gepi.10208
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[Inflammatory bowel diseases (IBD) -- critical discussion of etiology, pathogenesis, diagnostics, and therapy]
Publication Year: 2003 Source: Radiologe PMID: 12552369 DOI: 10.1007/s00117-002-0844-9
The operative treatment of elderly patients with inflammatory bowel disease (IBD) has often been avoided in favor of medical management because of a perceived increase in surgical risk. This study sought to define the following in the elderly IBD patient population: (1) the risk of surgical management and (2) those …
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