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CARD15/NOD2 risk alleles in the development of Crohn's disease in the Australian population
Publication Year: 2003 Source: Ann Hum Genet PMID: 12556233 DOI: 10.1046/j.1469-1809.2003.00006.x
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The genetics of inflammatory bowel disease
Publication Year: 2003 Source: Gastroenterology PMID: 12557156 DOI: 10.1053/gast.2003.50045
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestine, commonly diagnosed as either ulcerative colitis (UC) or Crohn's disease (CD). Epidemiological studies have consistently shown that both genetic and environmental factors influence the pathogenesis of IBD. A number of genome scans have been conducted in cohorts of …
Anti-TNF therapy for Crohn's disease
Publication Year: 2003 Source: Curr Pharm Des PMID: 12570820 DOI: 10.2174/1381612033391982
Autosomal dominant high myopia, a genetic disorder already mapped to region 18p11.31, is common in Carloforte (Sardinia, Italy), an isolated village of 8,000 inhabitants descending from a founder group of 300 in the early 1700s. Fifteen myopic propositi and 36 normal controls were selected for not having ancestors in common …
Modification of intestinal flora in the treatment of inflammatory bowel disease
Publication Year: 2003 Source: Curr Pharm Des PMID: 12570821 DOI: 10.2174/1381612033391883
Comment in Gastroenterology. 2004 Feb;126(2):625-7. The inflammatory bowel diseases (IBD) comprise complex genetic disorders, with multiple contributing genes. Linkage studies have implicated several genomic regions as likely containing IBD susceptibility genes, with some observed uniquely in Crohn's disease (CD) or ulcerative colitis (UC), and others common to both disorders. The …
B cell developmental requirement for the G alpha i2 gene
Publication Year: 2003 Source: J Immunol PMID: 12574334 DOI: 10.4049/jimmunol.170.4.1707
Most disease association mapping algorithms are based on hypothesis testing procedures that test one variant at a time. Those methods lose power when the disease mutations are jointly tagged by multiple variants, or when gene-gene interaction exist. Nearby variants are also correlated, for which procedures ignoring the dependence between variants …
Insurance problems among inflammatory bowel disease patients: results of a Dutch population based study
Publication Year: 2003 Source: Gut PMID: 12584216 DOI: 10.1136/gut.52.3.358
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Safety and efficacy of intravenous pulse cyclophosphamide in acute steroid refractory inflammatory bowel disease
Publication Year: 2003 Source: Gut PMID: 12584219 DOI: 10.1136/gut.52.3.377
Using a disease specific instrument to measure the health related quality of life (HRQOL) of patients with inflammatory bowel disease (IBD), it has been shown that their perceived HRQOL worsens during active disease. The precise factors involved in HRQOL changes reported by these patients are largely unknown. Our aim was …
Contrast enhanced magnetic resonance imaging of the terminal ileum in children with Crohn's disease
Publication Year: 2003 Source: Gut PMID: 12584222 DOI: 10.1136/gut.52.3.393
Obesity is a multigenic trait that has a substantial genetic component. Animal models confirm a role for gene-gene interactions, and human studies suggest that as much as one-third of the heritable variance may be due to nonadditive gene effects. To evaluate potential epistatic interactions among five regions, on chromosomes 7, …
Bronchial hyperreactivity and allergic status in inflammatory bowel disease
Publication Year: 2003 Source: Respiration PMID: 12584393 DOI: 10.1159/000068407
BACKGROUND & AIMS: Clostridium difficile-associated disease (CDAD) rates have been increasing. We sought to determine whether CDAD incidence has increased specifically in hospitalized patients with IBD. We also explored possible differences in the risk for and time to presentation of CDAD between IBD and non-IBD patients. METHODS: We analyzed hospital …
Multitrait fine mapping of quantitative trait loci using combined linkage disequilibria and linkage analysis
Publication Year: 2003 Source: Genetics PMID: 12586725 DOI: 10.1093/genetics/163.1.405
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