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Manipulation of the bacterial flora in inflammatory bowel disease
Publication Year: 2003 Source: Best Pract Res Clin Gastroenterol PMID: 12617882 DOI: 10.1053/bega.2002.0344
Inflammatory bowel diseases (IBDs) are chronic debilitating conditions, which impair the patient's quality of life significantly. Among them, Crohn's disease and ulcerative colitis are idiopathic disorders for which an infective etiology has long been sought. Here, we present an opinion in support of the hypothesis that bacterial superantigens can participate …
Strategies for targeting tumour necrosis factor in IBD
Publication Year: 2003 Source: Best Pract Res Clin Gastroenterol PMID: 12617886 DOI: 10.1053/bega.2002.0345
The aim of the present study was to develop a single unit, site-specific drug formulation allowing targeted drug release in the colon. Tablets were prepared using polysaccharides or synthetic polymer as binders. These included xanthan gum, guar gum, chitosan and Eudragit E. Indomethacin was used as a model drug. The …
Transfection of IL-10 expression vectors into endothelial cultures attenuates alpha4beta7-dependent lymphocyte adhesion mediated by MAdCAM-1
Publication Year: 2003 Source: BMC Gastroenterol PMID: 12625840 DOI: 10.1186/1471-230x-3-3
Comment in Am J Gastroenterol. 2000 Apr;95(4):1095. OBJECTIVE: Our aim was to investigate the prevalence of antineutrophil cytoplasmic antibodies (ANCA) in Japanese patients with ulcerative colitis (UC) and Crohn's disease (CD), and the putative antigens recognized by perinuclear staining pattern ANCA (p-ANCA)-positive sera. METHODS: Sera from UC (n = 52) …
CARD15/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn's disease
Publication Year: 2003 Source: Gut PMID: 12631669 DOI: 10.1136/gut.52.4.558
BACKGROUND: Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation and increased epithelial permeability. Both tumour necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) have been implicated in IBD. AIMS: To understand better the effects of these cytokines on epithelial cell function. METHODS: T84 cells were cultured with IFN-gamma …
Attenuated mild colonic inflammation and improved survival from severe DSS-colitis of transgenic Cu/Zn-SOD mice
Publication Year: 2003 Source: Free Radic Biol Med PMID: 12633752 DOI: 10.1016/s0891-5849(02)01426-0
Altered mucosal integrity and increased cytokine production, including tumor necrosis factor (TNF), are the hallmarks of inflammatory bowel disease (IBD). In this study, we addressed the role of TNF receptors (TNFR) on intestinal epithelial cell migration in an in vitro wound closure model. With mouse TNFR1 or TNFR2 knockout intestinal …
Genome-wide search in Finnish families with inflammatory bowel disease provides evidence for novel susceptibility loci
Publication Year: 2003 Source: Eur J Hum Genet PMID: 12634858 DOI: 10.1038/sj.ejhg.5200936
OBJECTIVE: Eotaxin is a recently characterized chemokine with potent and selective chemotactic activity for eosinophils. Previous studies indicating that eosinophils accumulate and become activated in inflammatory bowel disease (IBD) led us to hypothesize that eotaxin is potentially involved in the pathophysiology of IBD and, therefore, that eotaxin would be increased …
Inflammatory bowel disease in pregnancy
Publication Year: 2003 Source: Gastroenterol Clin North Am PMID: 12635421 DOI: 10.1016/s0889-8553(02)00068-7
BACKGROUND: Statin medications have antiinflammatory effects. We sought to determine whether statin use in persons with inflammatory bowel disease (IBD) was associated with reduced rates of steroid use or other markers of disease activity. METHODS: We performed a retrospective cohort study using administrative data. Statin users with IBD were compared …
Curcumin attenuates DNB-induced murine colitis
Publication Year: 2003 Source: Am J Physiol Gastrointest Liver Physiol PMID: 12637253 DOI: 10.1152/ajpgi.00449.2002
Identification of factors involved in the initiation, amplification, and perpetuation of the chronic immune response and the identification of markers for the characterization of patient subgroups remain critical objectives for ongoing research in inflammatory bowel disease (IBD). The Human Genome Project and the development of the expressed sequence tag (EST) …
Prevention of acetic acid-induced colitis by desferrithiocin analogs in a rat model
Publication Year: 2003 Source: Dig Dis Sci PMID: 12643622 DOI: 10.1023/a:1021908417220
BACKGROUND AND AIMS: CD40/CD40 ligand (CD40L) interaction is important for induction of T cell dependent antibody production and cell-mediated immune responses. Overexpression of CD40/CD40L in the intestinal mucosa is likely to be involved in the pathogenesis of inflammatory bowel disease (IBD). A soluble form of CD40L (sCD40L) exists in the …
Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice
Publication Year: 2003 Source: Dig Dis Sci PMID: 12643623 DOI: 10.1023/a:1021960401290
OBJECTIVE: People with inflammatory bowel disease (IBD) manifest great variability in health status, but little research has examined correlates of this variability, especially among adolescents with IBD. This study examined family dysfunction, maternal physical symptoms and maternal positive affect (PA) as correlates of variability in depression, pain/fatigue, functional disability and …
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