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Methane production during lactulose breath test is associated with gastrointestinal disease presentation
Publication Year: 2003 Source: Dig Dis Sci PMID: 12645795 DOI: 10.1023/a:1021738515885
OBJECTIVE AND DESIGN: RDP58 is a novel anti-inflammatory peptide that inhibits TNF synthesis and upregulates heme oxygenase-1. RDP58 therapy was evaluated in the dextran sodium sulphate (DSS) model of chronic colitis. MATERIAL: Colitis was induced by giving DSS to mice (n = 8 animals/group). Toxicity studies were done in Rhesus …
Increase in podoplanin-expressing intestinal lymphatic vessels in inflammatory bowel disease
Publication Year: 2003 Source: Virchows Arch PMID: 12647212 DOI: 10.1007/s00428-002-0744-4
A very large pedigree derived from the Saguenay-Lac-St-Jean region of Quebec contains a branch where a distal chromosome 5q haplotype seems to cosegregate with bipolar affective disorder. The authors used a diagnosis model where Bipolar Types I and II and schizoaffective disorder bipolar type were considered as affected, while single …
Card15 and Crohn's disease: healthy homozygous carriers of the 3020insC frameshift mutation
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12650796 DOI: 10.1111/j.1572-0241.2003.07287.x
Sulfapyridine (SP), one of the metabolites of sulfasalazine (SASP), is further metabolized into N-acetylsulfapyridine (AcSP) by polymorphic N-acetyltransferase 2 (NAT2). NAT2 activity has been diagnosed by phenotyping, that is, evaluating plasma concentrations or urinary excretions of tentatively administered test drugs for dose individualization and avoidance of serious adverse events. Herein, …
Effects of trimetazidine on acetic acid-induced colitis in female Swiss rats
Publication Year: 2003 Source: J Toxicol Environ Health A PMID: 12653021 DOI: 10.1080/15287390306402
A general-purpose modeling framework for performing path and segregation analysis jointly, called SEGPATH (Province and Rao [1995] Stat. Med. 7:185-198), has been extended to cover "model-free" robust, variance-components linkage analysis, based on identity-by-descent (IBD) sharing. These extended models can be used to analyze linkage to a single marker or to …
A population- and family-based study of Canadian families reveals association of HLA DRB1*0103 with colonic involvement in inflammatory bowel disease
Publication Year: 2003 Source: Inflamm Bowel Dis PMID: 12656131 DOI: 10.1097/00054725-200301000-00001
CONTEXT: A link between measles virus-containing vaccines and inflammatory bowel disease (IBD) has been suggested by recent studies. OBJECTIVE: To address whether receipt or timing of measles-containing vaccine (MCV) increases risk for IBD. DESIGN: A case-control study. SETTING: Four large health maintenance organizations (HMOs) that are part of the Centers …
Meeting summary: Signal transduction pathways in immune and inflammatory cells. November 30-December 3, 2000, Amelia Island, Florida, U.S.A
Publication Year: 2003 Source: Inflamm Bowel Dis PMID: 12656135 DOI: 10.1097/00054725-200301000-00005
Nitric oxide (NO) is an important mediator of inflammation in several pathological conditions. Patients with lung diseases, like asthma, have higher levels of exhaled NO (eNO) in active disease in comparison with healthy volunteers. Aspirated colonic gas in patients with ulcerative colitis (UC) showed more than 100 times higher levels …
High-dose azathioprine in children with inflammatory bowel disease
Publication Year: 2003 Source: Aliment Pharmacol Ther PMID: 12656694 DOI: 10.1046/j.1365-2036.2003.01540.x
The only therapy in inflammatory bowel disease (IBD), which up to the mid-1990s was disease modifying, was immunosuppression with azathioprine. Other 'standard' therapies in IBD were merely symptomatic. With the advent of biological therapies, especially the chimeric monoclonal anti-TNF antibody infliximab, we start to target specific pathogenic disease mechanisms, which …
The rise and fall of isolation by distance in the anadromous brook charr (Salvelinus fontinalis Mitchill)
Publication Year: 2003 Source: Genetics PMID: 12663537 DOI: 10.1093/genetics/163.3.983
Infectious bursal disease (IBD) is an acute, highly contagious viral disease. The diagnosis of IBD depends on time-consuming and costly procedures, like virus isolation on chick embryos and histopathological examination. A double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA), immunoperoxidase and reverse transcription polymerase chain reaction (RT-PCR) were applied in this …
TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells
Publication Year: 2003 Source: Gastroenterology PMID: 12671897 DOI: 10.1053/gast.2003.50157
There have been multiple NOD2/CARD15 genotype-phenotype analyses undertaken in patients with Crohn's disease since the gene's discovery in 2001. This review focuses on the major published series based upon their size and on the presence of specific clinical and genetic information provided in the published material from 2001 to 2005. …
Association of NOD2 with Crohn's disease in a homogenous Irish population
Publication Year: 2003 Source: Eur J Hum Genet PMID: 12673278 DOI: 10.1038/sj.ejhg.5200954
The therapeutic effects of tryptanthrin (TRYP), a natural product from the medicinal plant Polygonum tinctorium, were examined in a murine model of inflammatory bowel disease (IBD). Colitis was induced by 5% dextran sodium sulfate (DSS) in drinking water for 7 days from day 0. TRYP (100 mg/kg) was administered orally …
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