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Combined analysis of genomewide scans for adult height: results from the NHLBI Family Blood Pressure Program
Publication Year: 2003 Source: Eur J Hum Genet PMID: 12673281 DOI: 10.1038/sj.ejhg.5200952
Virus-like particles (VLPs) are empty particles consisting of virus capsid proteins that closely resemble native virus but are devoid of the native viral nucleic acids and therefore have attracted significant attention as noninfectious vaccines. A recombinant baculovirus, vIBD-7, which encodes the structural proteins (VP2, VP3, and VP4) of infectious bursal …
Expression of platelet-derived endothelial cell growth factor in inflammatory bowel disease
Publication Year: 2003 Source: J Gastroenterol PMID: 12673445 DOI: 10.1007/s005350300041
Not found
Transitioning the paediatric IBD patient to adult care
Publication Year: 2003 Source: Best Pract Res Clin Gastroenterol PMID: 12676115 DOI: 10.1016/s1521-6918(02)00145-2
The idiopathic inflammatory bowel diseases (IBD), comprised of Crohn's disease (CD) and ulcerative colitis (UC), are related, complex genetic disorders. With the completion of the human genomic sequence, identification of genetic variants contributing to IBD susceptibility can now more systematically be identified. Significant genetic linkages have been observed on chromosomes …
Upregulation of interleukin-12 and -17 in active inflammatory bowel disease
Publication Year: 2003 Source: Scand J Gastroenterol PMID: 12678335 DOI: 10.1080/00365520310000672
Thiopurine drugs are the most common drugs used to maintain clinical remission in inflammatory bowel disease (IBD). Three single-nucleotide polymorphisms (SNPs), TPMT A719G (rs1142345), inosine triphosphate pyrophosphatase (ITPase) C94A (rs1127354) and multidrug resistance protein 4 MRP4 G2269A (rs3765534), have been reported to account for heightened sensitivity to thiopurine drugs in …
Cloning and nucleotide analysis of segment A gene of infectious bursal disease virus detected in Korea
Publication Year: 2003 Source: Virus Genes PMID: 12680697 DOI: 10.1023/a:1022342524830
BACKGROUND: Th1/Th2 imbalance is hypothesized to up-regulate some diseases and down-regulate others. Compared to controls, multiple sclerosis (MS) (Th1-mediated) has been linked to a reduced risk of allergy and asthma (Th2-mediated), based on patient questionnaire studies and a review of asthma medication. AIM: To investigate whether MS is associated with …
The future of GI and liver research: editorial perspectives: II. Modulating leukocyte recruitment to splanchnic organs to reduce inflammation
Publication Year: 2003 Source: Am J Physiol Gastrointest Liver Physiol PMID: 12684207 DOI: 10.1152/ajpgi.00023.2003
This article discusses patients with inflammatory bowel disease (IBD), a group which is at increased risk for colorectal carcinoma based on extent and duration of their disease. Patients with chronic IBD (at least 8-10 years duration) should be screened with colonoscopy every 1 to 2 years with multiple jumbo biopsies …
Association of inflammatory bowel disease with indicators for childhood antigen and infection exposure
Publication Year: 2003 Source: Int J Colorectal Dis PMID: 12687394 DOI: 10.1007/s00384-003-0484-1
BACKGROUND: Inflammatory bowel diseases (IBD) are a serious burden for both patients and health care providers because of the young age at which they occur and their chronic course. AIM: The purpose of this study was to assess how general practitioners (GPs) in the area of Camerino-Matelica, Marche (Central Italy) …
[Protein S and ischemic brain disease]
Publication Year: 2003 Source: Vojnosanit Pregl PMID: 12688118 DOI: 10.2298/vsp0301093r
Not found
Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease
Publication Year: 2003 Source: Gut PMID: 12692059 DOI: 10.1136/gut.52.5.720
BACKGROUND: Inherited risk factors have been suggested to play an important role in the pathogenesis of vascular complications of inflammatory bowel disease (IBD). The aim of the present study was to investigate the role of mutations associated with cardiovascular disease in IBD patients with or without vascular complications compared with …
Screening and surveillance for asymptomatic colorectal cancer in IBD
Publication Year: 2003 Source: Gut PMID: 12692070 DOI: 10.1136/gut.52.5.769
Not found
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