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Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution model
Publication Year: 2003 Source: Inflamm Bowel Dis PMID: 12792221 DOI: 10.1097/00054725-200305000-00003
OBJECTIVES: In patients with inflammatory bowel disease (IBD), little is known about the effect of long term corticosteroid therapy (CT) on the hypothalamic-pituitary-adrenal (HPA) axis function. Our aim was to assess HPA axis function in IBD, before the end of CT, during the tapering phase. METHODS: HPA axis function was …
IBD International Genetics Consortium: international cooperation making sense of complex disease
Publication Year: 2003 Source: Inflamm Bowel Dis PMID: 12792225 DOI: 10.1097/00054725-200305000-00007
Inflammatory bowel disease (IBD) is a chronic, disabling disease. A dysregulated immune response seems to play a pivotal role in the pathogenesis of this disorder. Here we will review current concepts of the adoptive transfer model of IBD with particular emphasis on early events in disease development. In the adoptive …
Increased tissue protein synthesis during spontaneous inflammatory bowel disease in HLA-B27 rats
Publication Year: 2003 Source: Clin Sci (Lond) PMID: 12793856 DOI: 10.1042/CS20020313
Signal transducer and activator of transcription 6 (STAT6) is a key transcription factor involved in interleukin 4 (IL-4) and IL-13-mediated Th2 response. The STAT6 gene is located on chromosome 12q13.3-14.1 (IBD2 region) and is therefore a positional and functional candidate gene for study in inflammatory bowel disease. We investigated the …
PG-mediated closure of paracellular pathway and not restitution is the primary determinant of barrier recovery in acutely injured porcine ileum
Publication Year: 2003 Source: Am J Physiol Gastrointest Liver Physiol PMID: 12801887 DOI: 10.1152/ajpgi.00532.2002
BACKGROUND: Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) are believed to play a significant role in the pathogenesis of inflammatory bowel disease (IBD). Interleukin-1 and TNF-alpha possess overlapping and synergetic activities inducing the production in cascade of other cytokines, adhesion molecules, arachidonic acid metabolites, as well as activating immune and …
[Costs of ambulant care for patients with inflammatory bowel disease in general practice]
Publication Year: 2003 Source: Z Gastroenterol PMID: 12806538 DOI: 10.1055/s-2003-39647
BACKGROUND: Research on the impact of parental illness on children is sparse, and it remains unclear what kind of support, if any, families would value. This paper presents findings from the first investigation to explore the experiences of young people who have a parent with inflammatory bowel disease (IBD). DESIGN …
Glial-derived neurotrophic factor regulates apoptosis in colonic epithelial cells
Publication Year: 2003 Source: Gastroenterology PMID: 12806607 DOI: 10.1016/s0016-5085(03)00404-9
The most important clinical features of the spondyloarthritides (SpA) are not only inflammatory back pain (IBP) but also peripheral (enthesitis) and extra-articular symptoms. For clinical purposes, two forms related to the predominant clinical manifestation - axial and peripheral SpA - and five subgroups- ankylosing spondylitis (AS), SpA associated with psoriasis …
How safe are the safest IBD drugs?
Publication Year: 2003 Source: Gastroenterology PMID: 12806636 DOI: 10.1016/s0016-5085(03)00568-7
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6-TG for IBD. simple, but safe?
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12809812 DOI: 10.1111/j.1572-0241.2003.07421.x
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Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12809828 DOI: 10.1111/j.1572-0241.2003.07413.x
BACKGROUND & AIMS: There are few systematic studies on the natural history or immunogenetic associations of erythema nodosum (EN) or ocular inflammation in inflammatory bowel disease (IBD), but they are reportedly more common in patients with other extraintestinal manifestations (EIMs), particularly arthritis. Immunogenetic associations have previously been described in IBD …
Work losses related to inflammatory bowel disease in the United States: results from the National Health Interview Survey
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12809829 DOI: 10.1111/j.1572-0241.2003.07285.x
Colorectal cancer (CRC) occurs with an increased incidence in individuals with chronic inflammatory bowel disease (IBD) of the colon. Recent data suggest that a family history of colorectal cancer is an independent risk factor for CRC in IBD, an observation that implies that genetic factors are relevant to the development …
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