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High prevalence of fatigue in quiescent inflammatory bowel disease is not related to adrenocortical insufficiency
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12809832 DOI: 10.1111/j.1572-0241.2003.07414.x
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Bone density in a population-based cohort of premenopausal adult women with early onset inflammatory bowel disease
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12809833 DOI: 10.1111/j.1572-0241.2003.07415.x
We address the question of whether one can obtain increased power for finding a quantitative trait locus (QTL) if a gene x environment (G x E) interaction is incorporated directly into the linkage analysis. We consider both parametric and nonparametric analysis approaches to including G x E interaction. For the …
Intestinal tissue kallikrein-kallistatin profile in inflammatory bowel disease
Publication Year: 2003 Source: Int Immunopharmacol PMID: 12810351 DOI: 10.1016/S1567-5769(03)00054-7
The intricate nature of complex genetic traits dictates that novel methodologies be developed and utilized to achieve better power, better accuracy, and more favorable balance between type I and type II errors than could be achieved by the traditional methods as they are used in mapping Mendelian traits. Meta-analysis provides …
Relationship between the tumor necrosis factor alpha polymorphism and the serum C-reactive protein levels in inflammatory bowel disease
Publication Year: 2003 Source: Immunogenetics PMID: 12811429 DOI: 10.1007/s00251-003-0575-8
There is an acute need for effective therapy for inflammatory bowel disease (IBD), particularly at the level of repair of the damaged epithelium. We evaluated the efficacy of recombinant human keratinocyte growth factor (rHuKGF) in both the dextran sodium sulfate (DSS) and the CD4(+)CD45RB(Hi) T cell transfer models of IBD. …
Bone morphogenetic protein-7 reduces the severity of colon tissue damage and accelerates the healing of inflammatory bowel disease in rats
Publication Year: 2003 Source: J Cell Physiol PMID: 12811818 DOI: 10.1002/jcp.10275
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A method for the detection of eosinophilic granulocytes in colonoscopic biopsies from IBD patients
Publication Year: 2003 Source: Pathol Res Pract PMID: 12812315 DOI: 10.1078/0344-0338-00367
The gut flora plays a fundamental role in maintaining normal intestinal function. A disturbance of this flora, or the host response to this flora, has been clearly demonstrated to play a role in the pathogenesis of inflammatory bowel disease (IBD). This has led to attempts to modify the bacterial flora …
Testing linkage and gene x environment interaction: comparison of different affected sib-pair methods
Publication Year: 2003 Source: Genet Epidemiol PMID: 12813728 DOI: 10.1002/gepi.10244
Substantial evidence suggests a central role for TNF-alpha in the pathogenesis of IBD. This molecular observation has been supported by clinical trials with anti-TNF therapies. The most extensively investigated among the various anti-TNF agents is infliximab. Clinical trials to date have demonstrated its efficacy in inducing remission in patients with …
Review article: inherited thrombophilia in inflammatory bowel disease
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12818264 DOI: 10.1111/j.1572-0241.2003.07491.x
For diseases that do not follow a clear Mendelian pattern of inheritance nonparametric tests applied to affected sibs have been shown to be robust to the inherent uncertainty about the precise underlying genetic model. It is known that the weights optimizing the power of tests using IBD alleles shared by …
Fecal lactoferrin is a sensitive and specific marker in identifying intestinal inflammation
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12818275 DOI: 10.1111/j.1572-0241.2003.07458.x
Although genetic predisposition for inflammatory bowel disease (IBD) is well established, little is known about the accountable genes. The pathogenesis of IBD is characterized by an imbalanced activation of Th1- and Th2-lymphocytes. IL-10 represents an anti-inflammatory cytokine which downregulates the production of Th1-derived cytokines. To evaluate the role of the …
Mononuclear leukocytes bind to specific hyaluronan structures on colon mucosal smooth muscle cells treated with polyinosinic acid:polycytidylic acid: inter-alpha-trypsin inhibitor is crucial to structure and function
Publication Year: 2003 Source: Am J Pathol PMID: 12819017 DOI: 10.1016/s0002-9440(10)63636-x
Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are important causes of cholestatic liver disease. IgG4-associated cholangitis (IAC) also belongs to the same entity. Overlap syndromes combine characteristics of cholestatic liver diseases and autoimmune hepatitis. The diagnosis of PBC is based on the detection of anti-mitochondrial antibodies. PBC is …
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