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Probiotics, Irritable Bowel Syndrome, and Inflammatory Bowel Disease
Publication Year: 2003 Source: Curr Treat Options Gastroenterol PMID: 12846937 DOI: 10.1007/s11938-003-0020-y
A methodology is introduced for numerical evaluation, with any given accuracy, of the cumulative probabilities of the proportion of genome shared identical by descent (IBD) on chromosome segments by two individuals in a grandparent-type relationship. Programs are provided in the popular software package Maple for rapidly implementing such evaluations in …
Acquired microvascular dysfunction in inflammatory bowel disease: Loss of nitric oxide-mediated vasodilation
Publication Year: 2003 Source: Gastroenterology PMID: 12851871 DOI: 10.1016/s0016-5085(03)00699-1
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Bacteroides vulgatus protects against Escherichia coli-induced colitis in gnotobiotic interleukin-2-deficient mice
Publication Year: 2003 Source: Gastroenterology PMID: 12851881 DOI: 10.1016/s0016-5085(03)00672-3
BACKGROUND: YKL-40 is secreted by macrophages and neutrophils and is a growth factor for vascular endothelial cells and fibroblasts. Elevated serum concentrations of YKL-40 are found in patients with diseases characterized by inflammation or ongoing fibrosis. The aim of this study was to seek association between serum YKL-40 in patients …
Cerebrospinal fluid and plasma concentration of soluble intercellular adhesion molecule 1, vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule in patients with acute ischemic brain disease
Publication Year: 2003 Source: Vojnosanit Pregl PMID: 12852155 DOI: 10.2298/vsp0302139s
RATIONALE: Population and health services research can be performed by linkage analysis of administrative data. However, the robustness of study results is determined by the accuracy of the diagnostic coding. OBJECTIVES: To estimate the awareness, use and accuracy of the International Classification of Diseases, Ninth Revision (ICD-9) coding by physicians …
Bacterial load in animal models of acute and chronic 'reactivated' colitis
Publication Year: 2003 Source: Digestion PMID: 12853728 DOI: 10.1159/000071296
Proinflammatory cytokines and secretory phospholipase A(2) (sPLA(2)) are elevated in patients with inflammatory bowel disease (IBD). We previously reported that the proinflammatory cytokine IL-6 increased the expression of sPLA(2) (a hydrolyzer of phosphatidylcholine) and decreased membrane integrity in an intestinal epithelial cell culture model. To determine the physiological effects of …
Adenoviral transfer of the murine oncostatin M gene suppresses dextran-sodium sulfate-induced colitis
Publication Year: 2003 Source: J Interferon Cytokine Res PMID: 12856331 DOI: 10.1089/107999003765027393
Comment in Can J Gastroenterol. 2004 Mar;18(3):183-4. OBJECTIVE: We aimed to determine the bone mineral density (BMD) using dual energy x-ray absorptiometry in a population-based sample of women with inflammatory bowel disease who were diagnosed before age 20 yr and who are currently premenopausal and less than 45 yr. METHODS: …
Population genetic structure of rock ptarmigan Lagopus mutus in Northern and Western Europe
Publication Year: 2003 Source: Mol Ecol PMID: 12859645 DOI: 10.1046/j.1365-294x.2003.01889.x
Recently, a variety of mixed linear models have been proposed for marker-assisted prediction of the effects of quantitative trait loci (QTLs) in outbred populations of animals. One of them addresses the effects of a cluster of linked QTLs, or those of a particular chromosomal segment, marked by DNA marker(s) and …
The pathophysiology of bone disease in gastrointestinal disease
Publication Year: 2003 Source: Eur J Gastroenterol Hepatol PMID: 12867794 DOI: 10.1097/00042737-200308000-00004
In genome-wide screens of genetic marker loci, non-mendelian inheritance of a marker is taken to indicate its vicinity to a disease locus. Heritable complex traits are thought to be under the influence of multiple possibly interacting susceptibility loci yet the most frequently used methods of linkage and association analysis focus …
Immune abnormalities and endotoxemia in patients with ulcerative colitis and in their first degree relatives: attempts at neutralizing endotoxin-mediated effects
Publication Year: 2003 Source: Curr Pharm Des PMID: 12871178 DOI: 10.2174/1381612033454324
The aim of this study was to investigate the degree of agreement between parents and their offspring with inflammatory bowel disease for the presence of symptoms and the assessment of health-related quality of life (HRQOL). Factors influencing parent-child agreement were studied. Eighty-three Children and 81 parents separately filled out a …
Patient nonadherence to medication in inflammatory bowel disease
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12873575 DOI: 10.1111/j.1572-0241.2003.07522.x
gammadelta T cells have previously been shown to play a protective role in various animal models of chronic inflammation (e.g., experimental autoimmune encephalomyelitis, collagen-induced arthritis, and non-obese diabetes). This immunoregulatory potential is exerted by synthesizing various anti-inflammatory cytokines and growth factors (e.g., transforming growth factor-beta). As the normal balance between …
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