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Complementary and alternative medicine use by Canadian patients with inflammatory bowel disease: results from a national survey
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12873578 DOI: 10.1111/j.1572-0241.2003.07519.x
Intestinal microflora are believed to play an important role in the pathogenesis of inflammatory bowel disease (IBD). Mycoplasma have been suggested previously as organisms of ubiquitous distribution with the potential to cause inflammatory diseases, including IBD in susceptible individuals. The aim of this study was to determine the frequency of …
Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes
Publication Year: 2003 Source: Life Sci PMID: 12875900 DOI: 10.1016/s0024-3205(03)00490-9
The aim of the present paper is to briefly review the literature relating to clinical studies of the use of polyunsaturated long-chain fatty acids in the treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. The reasons for the discrepancies in the findings could be related …
Interleukin-10-based therapy for inflammatory bowel disease
Publication Year: 2003 Source: Expert Opin Biol Ther PMID: 12880373 DOI: 10.1517/14712598.3.5.725
GOALS: To evaluate the prevalence of (Hp) infection in a group of inflammatory bowel disease (IBD) outpatients and the possible influence of treatment. BACKGROUND: The low prevalence of Hp infection in these patients is usually attributed to environmental factors; the role of drugs has not been fully investigated. STUDY: Seventy-two …
An investigation of the distribution of antigen fed in tolerogenic or immunogenic forms
Publication Year: 2003 Source: Immunol Lett PMID: 12880685 DOI: 10.1016/s0165-2478(03)00076-2
Chronic inflammatory diseases of the intestine (i.e. Crohn's and chronic ulcerative colitis- collectively known as inflammatory bowel disease [IBD]) are a very significant public health problem in the United States and other industrialized nations. Thus, effort has been made toward understanding the biological mechanisms that regulate such inflammation. Largely, these …
[Relationship between patient's subjective stress perception and the course of inflammatory bowel disease]
Publication Year: 2003 Source: Gastroenterol Hepatol PMID: 12887854 DOI: 10.1016/s0210-5705(03)70382-3
BACKGROUND: Tumour necrosis factor (TNF) alpha and TNF-beta are soluble ligands binding to TNF receptors with similar activities; soluble TNF receptors neutralise TNF activity by acting as inhibitors. Little is known about the cytokine/soluble receptor role in inflammatory bowel disease (IBD). AIMS: To test the hypothesis that an imbalance in …
A group-based patient education programme for high-anxiety patients with Crohn disease or ulcerative colitis
Publication Year: 2003 Source: Scand J Gastroenterol PMID: 12889564 DOI: 10.1080/00365520310003309
Although the pathogenesis of inflammatory bowel disease (IBD) remains elusive, it appears that there is chronic activation of the immune and inflammatory cascade in genetically susceptible individuals. Current disease management guidelines have therefore focused on the use of anti-inflammatory agents, aminosalicylates and corticosteroids. These conventional therapies continue to be a …
Indication of linkage and genetic heterogeneity for asthma and atopy on chromosomes 8p and 12q in 107 French EGEA families
Publication Year: 2003 Source: Eur J Hum Genet PMID: 12891379 DOI: 10.1038/sj.ejhg.5201014
BACKGROUND: The involvement of enteropathogenic microorganisms in the pathogenesis of inflammatory bowel disease (IBD) and their importance in the different phases of inflammation are still unknown. AIM: To quantify the aerobic bacterial load in models of acute and chronic 'reactivated' colitis, and correlate this with damage. METHODS: Acute colitis was …
6-thioguanine can cause serious liver injury in inflammatory bowel disease patients
Publication Year: 2003 Source: Gastroenterology PMID: 12891528 DOI: 10.1016/s0016-5085(03)00938-7
BACKGROUND: Little information is available on the relative contribution of peptide growth factors and leukocyte-derived proteinases to the repair processes in inflammatory bowel disease (IBD). We investigated their possible roles in epithelial cell restitution and proliferation in patients with IBD. METHODS: The expression of hepatocyte growth factor (HGF), keratinocyte growth …
Zeta isoform of protein kinase C prevents oxidant-induced nuclear factor-kappaB activation and I-kappaBalpha degradation: a fundamental mechanism for epidermal growth factor protection of the microtubule cytoskeleton and intestinal barrier integrity
Publication Year: 2003 Source: J Pharmacol Exp Ther PMID: 12893839 DOI: 10.1124/jpet.103.053835
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Clinical features and pattern of indeterminate colitis: Crohn's disease with ulcerative colitis-like clinical presentation
Publication Year: 2003 Source: J Gastroenterol PMID: 12898357 DOI: 10.1007/s00535-003-1117-8
OBJECTIVES: The aims of this study were to investigate a possible positive correlation between B2-microglobulin (B2-M) serum levels and the severity and activity of inflammatory bowel disease (IBD); and to examine whether B2-M levels reflect IBD extent. METHODS: We examined B2-M serum levels in 87 ulcerative colitis (UC) patients, 74 …
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