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Estimation of the inbreeding coefficient through use of genomic data
Publication Year: 2003 Source: Am J Hum Genet PMID: 12900793 DOI: 10.1086/378207
Information from multiple genome scans and collaborative efforts suggests that schizophrenia is a heterogeneous, complex disorder with polygenic and environmental antecedents. In a previous paper we demonstrated that stratification of families on the basis of co-segregating phenotypes (psychotic affective disorders (PAD) and schizophrenia spectrum personality disorders (SSPD) in first-degree relatives …
Intracellular IL-1Ra type 1 inhibits IL-1-induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38 mitogen-activated protein kinase and NF-kappaB pathways
Publication Year: 2003 Source: Cytokine PMID: 12901852 DOI: 10.1016/s1043-4666(03)00182-0
Comment in Gastroenterology. 2003 May;124(5):1538-42. BACKGROUND & AIMS: The peroxisome proliferator-activated receptor gamma (PPAR gamma) has been proposed as a key inhibitor of colitis through attenuation of nuclear factor kappa B (NF-kappa B) activity. In inflammatory bowel disease, activators of NF-kappa B, including the bacterial receptor toll-like receptor (TLR)4, are …
Gastrointestinal side effects of drugs
Publication Year: 2003 Source: Expert Opin Drug Saf PMID: 12904098 DOI: 10.1517/14740338.2.4.421
Based on Pasteur's work on the microbial nature of fermentation, it was widely believed that the presence of bacteria in the intestine was essential for the life of the host. It has also been known for decades that gut commensal microbes effect the activation and development of the systemic immune …
The suppressive effect of bifidobacteria on Bacteroides vulgatus, a putative pathogenic microbe in inflammatory bowel disease
Publication Year: 2003 Source: Microbiol Immunol PMID: 12906096 DOI: 10.1111/j.1348-0421.2003.tb03368.x
OBJECTIVES: Crohn's disease (CD) can be classified by site of involvement and by clinical behavior. Claims for stability of behavior are based on patients who have had surgery, usually within 8 yr of diagnosis. Disease during this period may begin as inflammatory and may evolve into stricturing or fistulizing behavior. …
Aminosalicylates and colorectal cancer in IBD: a not-so bitter pill to swallow
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12907319 DOI: 10.1111/j.1572-0241.2003.07599.x
Individuals with inflammatory bowel disease (IBD) are known to have an increased incidence of thromboembolic disease. Activated protein C resistance (APCR) has been identified as one of several inherited disorders of coagulation that predispose individuals to thromboembolic problems. This resistance results from a single point mutation in the factor V …
The association between corticosteroid use and development of fractures among IBD patients in a population-based database
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12907335 DOI: 10.1111/j.1572-0241.2003.07590.x
BACKGROUND: Infliximab (IFX) and adalimumab (ADA) are attractive treatment options in patients with inflammatory bowel disease (IBD) also during pregnancy but there is still limited data on the benefit/risk profile of IFX and ADA during pregnancy. METHODS: This observational study assessed pregnancy outcomes in 212 women with IBD under antitumor …
Improved validation of the Inflammatory Bowel Disease Questionnaire and development of a short form in Greek patients
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12907336 DOI: 10.1111/j.1572-0241.2003.07518.x
Ulcerative colitis (UC) and Crohn's disease (CD) are two presentations of inflammatory bowel diseases (IBDs). Whereas the inflammation in UC is confined to the mucosa/submucosa, CD is considered a transmural disease with characteristic lymphoid aggregates with or without epithelioid granulomas in the subserosa. Here we examined and quantified the distribution …
Infliximab for treatment of pyoderma gangrenosum associated with inflammatory bowel disease
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12907338 DOI: 10.1111/j.1572-0241.2003.07581.x
Ulcerative colitis and Crohn's disease (together known as Inflammatory Bowel Disease or IBD) are both associated with increased risk for colorectal cancer. Although it is conventional to emphasise differences between IBD-associated and sporadic colon cancer, such as a lower rate of Adenomatosis Polyposis Coli mutations and earlier p53 mutations, IBD-associated …
Pediatric inflammatory bowel disease
Publication Year: 2003 Source: Child Adolesc Psychiatr Clin N Am PMID: 12910821 DOI: 10.1016/s1056-4993(03)00007-5
Chronic recurrent multifocal osteomyelitis (CRMO) is a clinicopathologic entity of unknown origin mainly affecting children and young adults. It shares many clinical features with pyoderma gangrenosum (PG), an uncommon ulcerating inflammatory disorder of the dermis and underlying subcutaneous fat. Both conditions are chronic and relapsing, and have been associated with …
Molecular characterization of the microbial species that colonize human ileal and colonic mucosa by using 16S rDNA sequence analysis
Publication Year: 2003 Source: J Appl Microbiol PMID: 12911699 DOI: 10.1046/j.1365-2672.2003.02005.x
INTRODUCTION: Inflammatory bowel disease often affects women during their reproductive years, causing management concerns for obstetricians caring for these patients during pregnancy. TREATMENT: Apart from methotrexate, most drugs used regularly to treat ulcerative colitis and Crohn's disease can safely be used by pregnant women. No causal relationship has been established …
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