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Tumour necrosis factor alpha and nuclear factor kappaB inhibit transcription of human TFF3 encoding a gastrointestinal healing peptide
Publication Year: 2003 Source: Gut PMID: 12912861 DOI: 10.1136/gut.52.9.1297
Crohn's disease and ulcerative colitis, the two major forms of idiopathic inflammatory bowel disease (IBD), are heritable, complex traits that appear to share some but not all susceptibility loci. We report that transmission/disequilibrium test analysis of a Crohn's disease genome scan dataset has detected an inflammatory bowel disease locus on …
Evaluation of 99mTc-HMPAO leukocyte scintigraphy in the investigation of pediatric inflammatory bowel disease
Publication Year: 2003 Source: J Pediatr PMID: 12915823 DOI: 10.1016/S0022-3476(03)00280-4
Hepatobiliary disorders occur frequently in patients with IBD, with PSC and cholangiocarcinoma being the most clinically significant for endoscopists. Endoscopic therapy for PSC is effective in improving symptoms, biochemical parameters, and radiographic abnormalities. Endoscopic therapy may also confer survival benefit, but this has yet to be confirmed in randomized, controlled …
Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis
Publication Year: 2003 Source: Cochrane Database Syst Rev PMID: 12917894 DOI: 10.1002/14651858.CD000543
OBJECTIVE AND DESIGN: To determine the effect of nicotine on colonic inflammation in the trinitrobenzenesulphonic acid (TNBS) model of inflammatory bowel disease in comparison with sulphasalazine. MATERIALS: Male Wistar rats were used for the in-vivo and ex-vivo studies. In-vitro studies were performed using human leukemia peripheral blood monocyte cells (THP-1 …
Progress in searching for susceptibility gene for inflammatory bowel disease by positional cloning
Publication Year: 2003 Source: World J Gastroenterol PMID: 12918095 DOI: 10.3748/wjg.v9.i8.1646
BACKGROUND: Persons with chronic diseases often do not receive preventive care at the same rate as the general population. Reasons for this are not clear. We conducted a cross-sectional survey of patients with inflammatory bowel disease (IBD) and controls to assess receipt of 10 preventive health services. METHODS: From March …
Prevalence of amebiasis in inflammatory bowel disease in Turkey
Publication Year: 2003 Source: World J Gastroenterol PMID: 12918132 DOI: 10.3748/wjg.v9.i8.1834
In recent years it has become clear that chronic inflammatory bowel disease (IBD), especially Crohn's disease (CD), is caused by a loss of tolerance against the autologous bacterial flora of the intestine. Tolerance against the indigenous flora requires optimal recognition of antigens by pattern recognition receptors and the presence of …
Association between mutations in the CARD15 (NOD2) gene and Crohn's disease in Israeli Jewish patients
Publication Year: 2003 Source: Am J Med Genet A PMID: 12923865 DOI: 10.1002/ajmg.a.20209
A strain of infectious bursal disease virus (IBDV) was detected from bursal tissues of chicks which suffered from infectious bursal disease (IBD) in Chinju, Korea and provisionally named as Chinju strain. A full-length cDNA clone for segment A gene of the virus was constructed, and complete nucleotide sequence of the …
Active inflammatory bowel disease: evaluation with 99mTc (V) DMSA scintigraphy
Publication Year: 2003 Source: Radiology PMID: 12925713 DOI: 10.1148/radiol.2291020692
OBJECTIVE: To establish the impairment of different dimensions of quality of life in inflammatory bowel disease (IBD). DESIGN: Prospective observational study. PARTICIPANTS: 289 patients [160 with ulcerative colitis (UC) and 129 with Crohn's disease (CD)]. MEASURES: Health-related quality of life was assessed by means of the Inflammatory Bowel Disease Questionnaire …
Advances in clinical laboratory tests for inflammatory bowel disease
Publication Year: 2003 Source: Clin Chim Acta PMID: 12927679 DOI: 10.1016/s0009-8981(03)00286-9
BACKGROUND: Previous investigations in rats have shown that the first enzyme of the mitochondrial electron transport chain (complex I) is altered in peripheral blood mononuclear cells (PBMCs) and muscle by dietary manipulations. OBJECTIVE: We hypothesized that similar changes would occur in human PBMCs as a result of dietary malnutrition and …
Regression models for linkage: issues of traits, covariates, heterogeneity, and interaction
Publication Year: 2003 Source: Hum Hered PMID: 12931047 DOI: 10.1159/000072313
Iron contributes significantly to the formation of reactive oxygen species via the Fenton reaction. Therefore, we assessed whether a series of desferrithiocin analogs, both carboxylic acids and hydroxamates, could (1) either promote or diminish the iron-mediated oxidation of ascorbate, (2) quench a model radical species, 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+), and (3) …
Efficiency robust tests for mapping quantitative trait loci using extremely discordant sib pairs
Publication Year: 2003 Source: Hum Hered PMID: 12931050 DOI: 10.1159/000072316
Recent studies have demonstrated that intracolonic administration of trinitrobenzenesulfonic acid (TNB) dissolved in ethanol produces chronic colitis in rats, and that this model shares many features of human inflammatory bowel disease (IBD), particularly Crohn's disease. We investigated the role of free radicals in the pathogenesis of this colitis model. In …
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