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Regression-based sib pair linkage analysis for binary traits
Publication Year: 2003 Source: Hum Hered PMID: 12931051 DOI: 10.1159/000072317
The key role and contribution of various pro-inflammatory cytokines in common chronic inflammatory disorders such as inflammatory bowel disease (IBD) has been thoroughly investigated in recent years. Besides IL-1, TNF-alpha has been identified as one of the central immune mediators controlling inflammatory processes. Not surprisingly, neutralisation of these cytokines has …
Ethanol-induced colitis prevents oral tolerance induction in mice
Publication Year: 2003 Source: Braz J Med Biol Res PMID: 12937790 DOI: 10.1590/s0100-879x2003000900013
Increased intestinal permeability has been proposed as one aetiological factor for inflammatory bowel diseases (IBD). We have previously found that intestinal permeability of a water-soluble contrast medium, iohexol, correlates with disease activity. The objective was to compare the iohexol test with the lactulose-mannitol ratio, which is a more extensively studied …
Measles, mumps, rubella (MMR) vaccine
Publication Year: 2003 Source: Indian J Pediatr PMID: 12940381 DOI: 10.1007/BF02723162
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A unified approach to modelling linkage to quantitative and qualitative traits
Publication Year: 2003 Source: Ann Hum Genet PMID: 12940918 DOI: 10.1046/j.1469-1809.2003.00033.x
We study the properties of a modified lod score method for testing linkage that incorporates linkage disequilibrium (LD-lod). By examination of its score statistic, we show that the LD-lod score method adaptively combines two sources of information: (a) the IBD sharing score which is informative for linkage regardless of the …
A model for the length of tracts of identity by descent in finite random mating populations
Publication Year: 2003 Source: Theor Popul Biol PMID: 12948676 DOI: 10.1016/s0040-5809(03)00071-6
A recurrent theme in the schema of pathogenetic mechanisms attributed to colorectal cancer (CRC) and inflammatory bowel disease (IBD) is the interaction between genes and environment. Dietary and other environmental factors, and lower intestinal flora and their chemical interactions occur in the pathogenesis of both. Events at the mucosal surface …
Central effects of selective NK1 and NK3 tachykinin receptor agonists on two models of experimentally-induced colitis in rats
Publication Year: 2003 Source: Peptides PMID: 12948843 DOI: 10.1016/s0196-9781(03)00161-x
Based on the assumption that the delivery of ellagic acid to its site of action would show an antiinflammatory activity in inflammatory bowel disease (IBD), we have prepared microspheres using a new pH-sensitive polymer, Eudragit P-4135F (P-4135F), to deliver ellagic acid to the lower small intestine in rats. The microspheres …
IBD indirect costs: the sleeping giant?
Publication Year: 2003 Source: Gastroenterology PMID: 12949746 DOI: 10.1016/s0016-5085(03)01127-2
Not found
Differential mucosal expression of three superoxide dismutase isoforms in inflammatory bowel disease
Publication Year: 2003 Source: J Pathol PMID: 12950012 DOI: 10.1002/path.1407
The increasing incidence of Crohn's disease has lead to speculation about changes in exposures to environmental or infectious agents. Considerable attention has focused on the role of measles infection and/or vaccination in the pathogenesis of Crohn's disease and ulcerative colitis. Current evidence regarding the association between measles vaccination and inflammatory …
Imbalanced secondary mucosal antioxidant response in inflammatory bowel disease
Publication Year: 2003 Source: J Pathol PMID: 12950013 DOI: 10.1002/path.1408
BACKGROUND AND AIMS: In chronic inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis an aberrant mucosal immune regulation is observed accompanied by upregulation of proinflammatory cytokines. Lamina propria T cells of inflamed mucosa have an activated phenotype characterized by increased expression of surface markers such as CD25. …
Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants
Publication Year: 2003 Source: J Pathol PMID: 12950014 DOI: 10.1002/path.1409
Inflammatory bowel disease (IBD) is a chronic disorder whose etiology is linked to triggering events, including viral infections, that lead to immunoregulatory dysfunction in genetically susceptible people. Characteristic pathological changes include increased mononuclear leukocyte influx into the intestinal mucosa as well as mucosal smooth muscle cell (M-SMC) hyperplasia. Virus infection …
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