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Review article: the incidence and prevalence of colorectal cancer in inflammatory bowel disease
Publication Year: 2003 Source: Aliment Pharmacol Ther PMID: 12950413 DOI: 10.1046/j.1365-2036.18.s2.2.x
Comment in Z Gastroenterol. 2003 Sep;41(9):963-4. BACKGROUND: Outpatient care managed by general practitioners plays an important role in diagnostic and treatment of inflammatory bowel diseases (IBD). The chronic recurrent course often requires intensive and costly medical care. OBJECTIVE: To measure the costs of outpatient care for patients with IBD provided …
Review article: the data supporting a role for aminosalicylates in the chemoprevention of colorectal cancer in patients with inflammatory bowel disease
Publication Year: 2003 Source: Aliment Pharmacol Ther PMID: 12950416 DOI: 10.1046/j.1365-2036.18.s2.3.x
Peripheral tachykinins (TKs) are believed to play a role in the pathogenesis of inflammatory bowel diseases (IBD). In this study we investigated changes induced by central administration of two natural TK receptor agonists, NK(1) (PG-SPI) and NK(3) (PG-KII), on trinitrobenzene sulphonic acid (TNBS)- and dextran sodium sulphate (DSS)-induced experimental colitis …
IL-6 induces NF-kappa B activation in the intestinal epithelia
Publication Year: 2003 Source: J Immunol PMID: 12960348 DOI: 10.4049/jimmunol.171.6.3194
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Cytokines, chemokine receptors, and homing molecule distribution in the rectum and stomach of pediatric patients with ulcerative colitis
Publication Year: 2003 Source: J Pediatr Gastroenterol Nutr PMID: 12960653 DOI: 10.1097/00005176-200309000-00018
CD4+ T cells play an important role in the aetiology of inflammatory bowel disease (IBD), but it is not clear which factor(s) cause activation of these cells. The aim of this study was to examine the effects of adoptive transfer of splenic (CD4+) T cells from TNBS/ethanol-sensitized donor rats to …
Evaluating the prophylactic potential of zafirlukast against the toxic effects of acetic acid on the rat colon
Publication Year: 2003 Source: Toxicol Lett PMID: 12962976 DOI: 10.1016/s0378-4274(03)00269-8
Bacteroides, a predominant commensal bacteria in the gut, are thought to be responsible for the development of inflammatory bowel disease (IBD). In the present study, we examined whether or not bifidobacteria suppress B. vulgatus, a representative pathogenic Bacteroides species, in both the coculture system and the gnotobiotic murine model. As …
Glucocorticoid resistance in inflammatory bowel disease
Publication Year: 2003 Source: J Endocrinol PMID: 12967327 DOI: 10.1677/joe.0.1780339
The etiology of inflammatory bowel disease (IBD) is still unknown. However, a satisfactory solution cannot be far away. IBD actually encompasses two diseases, i.e. Crohn's disease (CD) and ulcerous colitis (UC). These diseases resemble each other so closely that they cannot be distinguished even pathologically, but differ from each other …
Full pedigree quantitative trait locus analysis in commercial pigs using variance components
Publication Year: 2003 Source: J Anim Sci PMID: 12968689 DOI: 10.2527/2003.8192155x
BACKGROUND: Azathioprine is widely used as maintenance therapy in children with moderate to severe inflammatory bowel disease (IBD). There is no data on safety at higher doses and its impact on growth and surgical morbidity in children. METHODS: This retrospective cohort study included all children treated with azathioprine and diagnosed …
Evaluation of new therapies for inflammatory bowel disease
Publication Year: 2003 Source: Br J Clin Pharmacol PMID: 12968979 DOI: 10.1046/j.1365-2125.2003.01965.x
Idiopathic, chronic inflammatory bowel disease (IBD) refers to two diseases-ulcerative colitis (UC) and Crohn's disease (CD). Despite an abundant literature discussing the pathophysiology and treatment of these diseases, little if any empirical studies have focused on patients' subjective experiences with their diseases. The purpose of this paper was to identify …
Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990-2001
Publication Year: 2003 Source: Gut PMID: 12970135 DOI: 10.1136/gut.52.10.1432
Although inflammatory bowel disease (IBD) typically presents with gastrointestinal complaints, mucocutaneous lesions are commonly associated and can precede gastrointestinal symptoms, thereby alerting the clinician to the diagnosis of IBD before the onset of gastrointestinal symptoms. Nine children are reported who had no gastrointestinal symptoms suggestive of IBD but presented with …
Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients
Publication Year: 2003 Source: Gut PMID: 12970136 DOI: 10.1136/gut.52.10.1435
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