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TGF-beta1 production in inflammatory bowel disease: differing production patterns in Crohn's disease and ulcerative colitis
Publication Year: 2003 Source: Clin Exp Immunol PMID: 12974764 DOI: 10.1046/j.1365-2249.2003.02250.x
The chemoprevention of colorectal cancer (CRC) with long-term sulfasalazine and 5-aminosalicyclic acid (5-ASA) treatment has been demonstrated through epidemiological and experimental studies, in patients with ulcerative colitis. In a large case-controlled study, there was a trend for long-term nonsteroidal anti-inflammatory consumption to be protective against CRC in patients with inflammatory …
Association of TNF-α-857C with Inflammatory Bowel Disease in the Australian Population
Publication Year: 2003 Source: Scand J Gastroenterol PMID: 28443765 DOI: 10.1080/00365520310002508
Comment in Int J Colorectal Dis. 2000 Jun;15(3):126. Inflammatory bowel diseases (IBDs) in humans are complex chronic inflammatory disorders of largely unknown cause. Several mouse models that in some respects resemble human IBDs have recently been developed and have provided new insights into immunoregulatory processes in the gut. Both genetic …
Mechanisms of active intestinal inflammation and potential down-regulation via lipoxins
Publication Year: 2002 Source: Adv Exp Med Biol PMID: 12664590 DOI: 10.1007/978-1-4615-0193-0_35
In order to differentiate infectious bursal disease virus (IBDV) isolates/strains, a quick method of RT-PCR followed by restriction enzyme analysis of VP1 gene sequence is being reported for the first time. A 480 bp fragment, comprising one of the RNA dependent RNA polymerase motifs of VP1 gene sequence of an …
Simple deterministic identity-by-descent coefficients and estimation of QTL allelic effects in full and half sibs
Publication Year: 2002 Source: Genet Res PMID: 12688663 DOI: 10.1017/s0016672302005918
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Inflammatory bowel disease
Publication Year: 2002 Source: Clin Cornerstone PMID: 12739326 DOI: 10.1016/s1098-3597(02)90005-0
BACKGROUND: The involvement of oxidant/antioxidant imbalance in the development of inflammatory bowel disease (IBD) is well documented. Two members of the glutathione S-transferase (GST) family of enzymes, GSTM1 and GSTT1, known to take part in cellular protection against electrophiles, demonstrate common deletion variants (termed null) associated with impaired enzyme function. …
Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p
Publication Year: 2002 Source: Proc Natl Acad Sci U S A PMID: 11752413 DOI: 10.1073/pnas.261567999
OBJECTIVE: To determine the prevalence of complementary and alternative medicine (CAM) use over time in a population-based cohort of patients with inflammatory bowel disease (IBD). METHODS: The Manitoba IBD Cohort Study is a longitudinal, population-based study of multiple determinants of health outcomes in an IBD cohort. Participants completed semi-annual surveys, …
Mixture models for linkage analysis of affected sibling pairs and covariates
Publication Year: 2002 Source: Genet Epidemiol PMID: 11754473 DOI: 10.1002/gepi.1043
Patients with chronic inflammatory bowel diseases (IBD) are at increased risk to develop osteopenia and osteoporosis. New parameters for the assessment of bone formation and especially bone resorption have significantly improved the diagnostic procedures to characterize bone metabolism. Biochemical characterization of bone turnover in IBD patients may provide important information …
Bacteroides ovatus as the predominant commensal intestinal microbe causing a systemic antibody response in inflammatory bowel disease
Publication Year: 2002 Source: Clin Diagn Lab Immunol PMID: 11777829 DOI: 10.1128/cdli.9.1.54-59.2002
Ulcerative colitis and Crohn's disease are inflammatory disorders of the gastrointestinal tract that are distributed unevenly within populations and throughout the world. Although the exact causes of inflammatory bowel disease (IBD) remain unknown, study of the epidemiology of IBD has provided insight into pathogenesis. This article examines the geographic, ethnic, …
Effects of regional hypoxia and acidosis on Rb(+) uptake and energetics in isolated pig hearts: (87)Rb MRI and (31)P MR spectroscopic study
Publication Year: 2002 Source: Biochim Biophys Acta PMID: 11781150 DOI: 10.1016/s0925-4439(01)00086-2
The aim of the study was to compare and analyze different noninvasive indices of cell damage in the isolated pig heart model of regional ischemia. We used (23)Na and (87)Rb MR imaging to evaluate Na(+)/K(+) balance, (31)P MR spectroscopy to measure energetics, and optical spectroscopy to assess oxymyoglobin (MbO(2)). Hearts …
Clinical aspects and pathophysiology of inflammatory bowel disease
Publication Year: 2002 Source: Clin Microbiol Rev PMID: 11781268 DOI: 10.1128/CMR.15.1.79-94.2002
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