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Budesonide in collagenous colitis: a double-blind placebo-controlled trial with histologic follow-up
Publication Year: 2002 Source: Gastroenterology PMID: 11781276 DOI: 10.1053/gast.2002.30295
In this review, I hope to have highlighted that cytokines are of crucial importance in the normal homeostasis of the gut immune system, the interactions of the gut immune system with enteric antigens and also in tissue injury associated with IBD. There is evidence from a number of different systems …
Mucosal flora in inflammatory bowel disease
Publication Year: 2002 Source: Gastroenterology PMID: 11781279 DOI: 10.1053/gast.2002.30294
Comment in Inflamm Bowel Dis. 2002 May;8(3):234-5. BACKGROUND & AIMS: Long-term treatment with azathioprine (AZA) is well established in inflammatory bowel disease (IBD). AZA is metabolized to 6-mercaptopurine (6-MP), which interacts in purine metabolism and is therefore considered to have mutagenic potentials. This is the first study to examine the …
Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice
Publication Year: 2002 Source: Gastroenterology PMID: 11781288 DOI: 10.1053/gast.2002.30347
BACKGROUND: Autophagy is a process of central importance for maintaining cell homeostasis, survival, and the regulation of inflammation. Recent studies associated variants within the gene loci, encoding protein tyrosine phosphatase nonreceptor type 2 (PTPN2), and autophagy genes, such as autophagy-related 16-like 1 (ATG16L1), with chronic inflammatory disorders, such as Crohn's …
Growth hormone has anabolic effects in glucocorticosteroid-dependent children with inflammatory bowel disease: a pilot study
Publication Year: 2002 Source: Metabolism PMID: 11782884 DOI: 10.1053/meta.2002.28972
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Thalidomide reduces tumour necrosis factor alpha and interleukin 12 production in patients with chronic active Crohn's disease
Publication Year: 2002 Source: Gut PMID: 11788559 DOI: 10.1136/gut.50.2.196
Helicobacter bilis and H. hepaticus, both urease-positive intestinal helicobacters of mice, have been shown experimentally to induce proliferative typhlocolitis in scid mice. We recently isolated a urease-negative Helicobacter sp. (H. sp.) that also induced proliferative typhlocolitis in pilot studies in scid mice. To determine the pathogenic potential of H. sp. …
Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared
Publication Year: 2002 Source: Trends Mol Med PMID: 11796261 DOI: 10.1016/s1471-4914(01)02194-3
Diarrhea is one of the common symptoms that significantly affects quality of life in patients with inflammatory bowel disease (IBD). The clinical manifestation of diarrhea is mainly dependant on the type of IBD and the location, extent and severity of intestinal inflammation. Understanding the pathophysiologic mechanisms of diarrhea in patients …
Inflammatory bowel disease in pregnancy
Publication Year: 2002 Source: Postgrad Med J PMID: 11796867 DOI: 10.1136/pmj.78.915.23
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Asymptomatic elevation of serum lipase and amylase in conjunction with Crohn's disease and ulcerative colitis
Publication Year: 2002 Source: Z Gastroenterol PMID: 11803494 DOI: 10.1055/s-2002-19636
Comment in Am J Gastroenterol. 2001 Apr;96(4):1301-2. OBJECTIVE: Patients with inflammatory bowel disease (IBD) are at increased risk for thromboembolic events. Hyperhomocysteinemia, which is an established risk factor for arterial as well as venous thrombosis, may be more prevalent in IBD because of vitamin deficiencies. METHODS: In this retrospective study, …
Risk of small bowel obstruction after the ileal pouch-anal anastomosis
Publication Year: 2002 Source: Ann Surg PMID: 11807359 DOI: 10.1097/00000658-200202000-00007
Update in Cochrane Database Syst Rev. 2017 Mar 03;3:CD004610. Update of Cochrane Database Syst Rev. 2007;(3):CD004610. BACKGROUND: Clostridium difficile is recognized as a frequent cause of antibiotic-associated diarrhea and colitis. OBJECTIVES: The aim of this review is to investigate the efficacy of antibiotic therapy for C. difficile-associated diarrhea (CDAD). SEARCH …
Shared care in gastroenterology: GPs' views of open access to out-patient follow-up for patients with inflammatory bowel disease
Publication Year: 2002 Source: Fam Pract PMID: 11818350 DOI: 10.1093/fampra/19.1.53
Macrophages play a central role during the pathogenesis of inflammation. In normal intestinal mucosa surface expression of typical macrophage markers such as CD14, CD16, CD11b or T-cell co-stimulatory molecules such as CD80 or CD86 is low indicating anergy and low pro-inflammatory activity of these cells. During inflammatory bowel disease (IBD) …
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