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Patient web-resource interest and internet readiness in pediatric inflammatory bowel disease
Publication Year: 2002 Source: J Pediatr Gastroenterol Nutr PMID: 12394377 DOI: 10.1097/00005176-200210000-00011
Comment in Gut. 2001 Sep;49(3):455. BACKGROUND AND AIMS: Genetic predisposition for inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic linkage studies. Genetic linkage of IBD to chromosome 3 has been observed previously. A high density analysis of chromosome 3p was performed to confirm prior linkages and elucidate …
Pregnancy, delivery, and pouch function after ileal pouch-anal anastomosis for ulcerative colitis
Publication Year: 2002 Source: Dis Colon Rectum PMID: 12394423 DOI: 10.1007/s10350-004-6411-x
A number of metabolic alterations are initiated by cerebral ischemia including dramatic increases in lactate concentration, decreases in N-acetylaspartate, choline, and creatine concentrations, as well as changes in amino acid levels. A review of proton nuclear magnetic resonance spectroscopy studies of focal and global cerebral ischemia in rats is presented …
Pediatricians overestimate importance of physical symptoms upon children's health concerns
Publication Year: 2002 Source: Med Care PMID: 12395031 DOI: 10.1097/00005650-200210000-00015
BACKGROUND AND OBJECTIVE: Inflammatory bowel disease (IBD) is a polygenic complex trait. The expression and presence in biopsiae from IBD patients points to a putative role of these genes in genetic susceptibility to IBD. This is the first association study on these genes in relation with IBD. PATIENTS AND METHOD: …
Adherent-invasive Escherichia coli: a putative new E. coli pathotype associated with Crohn's disease
Publication Year: 2002 Source: Int J Med Microbiol PMID: 12398209 DOI: 10.1078/1438-4221-00201
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Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells
Publication Year: 2002 Source: Gastroenterology PMID: 12404227 DOI: 10.1053/gast.2002.36588
The pathogeny of ulcerative colitis (UC) is not yet elucidated, but some arguments suggest the implication of genetic factors. Among the candidate genes, those encoding for HLA class II genotypes have been extensively studied in UC; however, discordant data may be imputable to heterogeneity, characterized by immunological markers such as …
Rapid development of colitis in NSAID-treated IL-10-deficient mice
Publication Year: 2002 Source: Gastroenterology PMID: 12404228 DOI: 10.1053/gast.2002.1231527
Ulcerative colitis (UC) and Crohn's disease (CD) are the clinical entities comprising idiopathic inflammatory bowel disease (IBD). Previous studies on the association of IBD and human leukocyte antigen (HLA) class II genes suggested a role for HLA in this disease. Here we present HLA class II (DRB1, DQB1, DQA1, DPB1) …
Methotrexate in IBD--move over 6-MP? Not so fast..
Publication Year: 2002 Source: Gastroenterology PMID: 12404250 DOI: 10.1053/gast.2002.1231737
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Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies for inflammatory bowel disease: high prevalence in patients with celiac disease
Publication Year: 2002 Source: J Clin Immunol PMID: 12405161 DOI: 10.1023/a:1019926121972
Comment in J Gastroenterol. 2002;37(10):874-5. BACKGROUND: The goal of this study was to evaluate the accuracy of computerized tomography (CT) and 99mTc-white blood cell (WBC) scintigraphy versus colonoscopy in assessing inflammatory bowel diseases (IBD) in a large population of children. METHODS: In a patient population of 313 consecutive children who …
Probiotics--role in inflammatory bowel disease
Publication Year: 2002 Source: Dig Liver Dis PMID: 12408442 DOI: 10.1016/s1590-8658(02)80166-9
We describe methodology for the diagnosis of human cancer, at high levels of accuracy, sensitivity, and specificity, by 1H NMR of tissue biopsies. This method is made robust and accurate by careful specimen preparation, and by multivariate analysis of spectral data. Examples are presented for the diagnosis of cancer of …
Blockade of NF-kappaB activation and donation of nitric oxide: new treatment options in inflammatory bowel disease?
Publication Year: 2002 Source: Scand J Gastroenterol Suppl PMID: 12408502 DOI: 10.1080/003655202320621436
Na+/H+ exchangers (NHEs) are integral transmembrane proteins found in all mammalian cells. There is substantial evidence indicating that NHEs regulate inflammatory processes. Because intestinal epithelial cells express a variety of NHEs, we tested the possibility that NHEs are also involved in regulation of the epithelial cell inflammatory response. In addition, …
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