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Binders for colon specific drug delivery: an in vitro evaluation
Publication Year: 2002 Source: Int J Pharm PMID: 12433431 DOI: 10.1016/s0378-5173(02)00398-8
Comment in Am J Gastroenterol. 2000 Mar;95(3):830. OBJECTIVE: Cyclosporin (CSA) is a promising alternative for patients with severe steroid-refractory ulcerative colitis (UC) previously facing only surgical options. Concerns over the long term efficacy and side effects resulted in this investigation of the University of Chicago's 5-yr CSA experience in these …
Antigranulocyte monoclonal antibody immunoscintigraphy in inflammatory bowel disease in children and young adolescents
Publication Year: 2002 Source: Acta Paediatr PMID: 12434889 DOI: 10.1080/080352502760311539
OBJECTIVE: To compare the incidence and clinical characteristics of lower gastrointestinal (LGI) bleeding due to ischemic colitis with those with LGI bleeding of other causes. METHODS: A chart review was performed of patients admitted with LGI bleeding to Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, between July 1, …
[Hospital study of the incidence of inflammatory bowel disease in the health district of Mérida (Spain)]
Publication Year: 2002 Source: Gastroenterol Hepatol PMID: 12435304 DOI: 10.1016/s0210-5705(02)70309-9
Epidemiological studies suggest that inflammatory bowel disease (IBD) is common in developed countries and rare in countries where intestinal nematode infections are common. T cells are critical in many immune responses, including those associated with IBD and nematode infection. Among the distinct T helper (Th) cell subsets, Th1-type immune response …
Log-linear models for gene mapping with affected sib pair data
Publication Year: 2002 Source: Hum Hered PMID: 12435886 DOI: 10.1159/000066196
BACKGROUND: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells (EEC), leading to increased ceramide levels. AIM: To determine whether ceramide induces apoptosis in IEC. METHODS: Apoptosis was evaluated by annexin-V binding …
Pseudomonas fluorescens encodes the Crohn's disease-associated I2 sequence and T-cell superantigen
Publication Year: 2002 Source: Infect Immun PMID: 12438326 DOI: 10.1128/IAI.70.12.6567-6575.2002
Similar to in the upper gastrointestinal tract, prostaglandins represent one of the most important components of mucosal defense in the small intestine and colon. The effects of prostaglandins in this context are widespread, ranging from maintenance of blood flow to stimulation of mucus secretion to modulation of the mucosal immune …
Association of ulcerative colitis with the inflammatory bowel disease susceptibility locus IBD2 in non-Jewish Caucasians and evidence of genetic heterogeneity among racial and ethnic populations with Crohn disease
Publication Year: 2002 Source: Am J Med Genet PMID: 12439891 DOI: 10.1002/ajmg.10762
AIM: Diagnostic delay for inflammatory bowel disease (IBD) is frequent, especially in paediatric patients. Scintigraphy with labelled leucocytes has been proposed as a very sensitive diagnostic tool for detecting bowel inflammation. The aim of this study was to evaluate the sensitivity and specificity of immunoscintigraphy in the diagnosis and follow-up …
The pathogenesis of inflammatory bowel disease: translational implications for clinicians
Publication Year: 2002 Source: Curr Gastroenterol Rep PMID: 12441038 DOI: 10.1007/s11894-002-0024-0
OBJECTIVES: To study the incidence of inflammatory bowel disease (IBD) in the health district of Mérida (Spain). MATERIAL AND METHODS: Retrospective hospital study of all patients diagnosed with IBD between 1/1/96 and 31/12/00 in the Hospital de Mérida, which is the reference center for a population of 158,407 inhabitants. Overall …
Assessing disease activity and disease activity indices for inflammatory bowel disease
Publication Year: 2002 Source: Curr Gastroenterol Rep PMID: 12441039 DOI: 10.1007/s11894-002-0025-z
The immunological and genetic pathogeneses of inflammatory bowel disease (IBD) have been well elucidated in the recent years. The pharmacologic treatment of IBDs accordingly becomes to focus upon the individual pathologic step (targeting therapy), whereas the therapeutic action is not yet a pinpoint one. It has been known recently that …
Treatment of the extraintestinal manifestations of inflammatory bowel disease
Publication Year: 2002 Source: Curr Gastroenterol Rep PMID: 12441042 DOI: 10.1007/s11894-002-0028-9
Research in the pathogenesis of inflammatory bowel disease (IBD) has dramatically broadened our understanding of these complex disorders. These clinical manifestations result from a dysregulated immune response in the presence of luminal bacteria. Recent identification of mutations in the NOD2 gene, a protein involved in the sensing of bacteria, offers …
Polyunsaturated fatty acids and inflammatory diseases
Publication Year: 2002 Source: Biomed Pharmacother PMID: 12442911 DOI: 10.1016/s0753-3322(02)00256-1
We have previously reported that in peripheral blood mononuclear cells (PBMC), the augmented expression of the beta isoform of the human glucocorticoid receptor (hGRbeta), as a putative dominant negative regulator of glucocorticoid action, is associated with glucocorticoid (GC) unresponsiveness of UC patients. In this study, we quantified the levels and …
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