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Intestinal drug delivery systems with biodegradable microspheres targeting mucosal immune-regulating cells for chronic inflammatory colitis
Publication Year: 2002 Source: J Gastroenterol PMID: 12572865 DOI: 10.1007/BF03326413
The intestinal epithelium serves as a protective barrier between the gut lumen and the underlying mucosa. During intestinal inflammation in inflammatory bowel disease (IBD) there is increased paracellular permeability and strong migration of the neutrophils into the mucosa as well as transepithelial neutrophil migration with the formation of crypt abscesses. …
Gene expression profile after peroxisome proliferator activator receptor-gamma ligand administration in dextran sodium sulfate mice
Publication Year: 2002 Source: J Gastroenterol PMID: 12572868 DOI: 10.1007/BF03326416
Many studies are done in small isolated populations and populations where marriages between relatives are encouraged. In this paper, we point out some problems with applying the maximum lod score (MLS) method (Risch, [1990] Am. J. Hum. Genet. 46:242-253) in these populations where relationships exist between the two parents of …
Intestinal microflora as a therapeutic target in inflammatory bowel disease
Publication Year: 2002 Source: J Gastroenterol PMID: 12572870 DOI: 10.1007/BF03326418
Of all patients with Crohn disease and ulcerative colitis, the first presentation of inflammatory bowel disease (IBD) is at a paediatric or adolescent age in 20% to 30%, most children being prepubertal at diagnosis. It is essential to provide an accurate diagnosis in children suspected of IBD, as the initial …
ICOS costimulation in inflammatory bowel disease
Publication Year: 2002 Source: J Gastroenterol PMID: 12572871 DOI: 10.1007/BF03326419
The present study was undertaken to determine the effectiveness in including VP2 gene of the large segment genome of infectious bursal disease virus (IBDV) in the DNA vaccine for protection of chickens against infectious bursal disease (IBD). Different fragments of the large segment gene of IBDV standard challenge (STC) strain …
Pharmacogenomic analysis of rhIL-11 treatment in the HLA-B27 rat model of inflammatory bowel disease
Publication Year: 2002 Source: Pharmacogenomics J PMID: 12629504 DOI: 10.1038/sj.tpj.6500137
BACKGROUND: The association between ulcerative colitis (UC), Crohn disease (CD) and colorectal cancer (CRC) has been confirmed in several studies. The aim of this study was critical analysis of the relation between IBD and malignancy. METHODS: Review of the literature. RESULTS: In UC, the extent of the disease, its duration …
Sentinel lymph node biopsy for cutaneous head and neck melanomas
Publication Year: 2002 Source: Arch Otolaryngol Head Neck Surg PMID: 11886345 DOI: 10.1001/archotol.128.3.285
BACKGROUND/AIMS: We recently discovered inflammatory bowel disease (IBD) in the ileum and cecum of SAMP1/Yit strain mice under specific pathogen-free (SPF) conditions. To determine the effect of lactic acid bacteria (LAB - Bifidobacterium breve, Bifidobacterium bifidum and Lactobacillus acidophilus)-fermented milk on the prevention of IBD in SAMP1/Yit strain mice, we …
Dehydroepiandrosterone in relation to other adrenal hormones during an acute inflammatory stressful disease state compared with chronic inflammatory disease: role of interleukin-6 and tumour necrosis factor
Publication Year: 2002 Source: Eur J Endocrinol PMID: 11888843 DOI: 10.1530/eje.0.1460365
BACKGROUND: Thalidomide improves clinical symptoms in patients with therapy refractory Crohn's disease, as shown in two recent studies. The mechanism of this effect however is still unknown. Suppression of tumour necrosis factor alpha (TNF-alpha) by thalidomide has been suggested as a possible mechanism. However, effects on other cytokines have not …
Uncoupling the p38 MAPK kinase in IBD: a double edged sword?
Publication Year: 2002 Source: Gut PMID: 11889058 DOI: 10.1136/gut.50.4.446
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The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review
Publication Year: 2002 Source: Gut PMID: 11889067 DOI: 10.1136/gut.50.4.485
OBJECTIVES: To evaluate the usefulness of 123I-labelled anti-vascular cell adhesion molecule-1 (VCAM-1) monoclonal antibody (MAb) scintigraphy in the assessment of colonic inflammatory damage. DESIGN: Colitis was induced by intracolonic administration of 30 mg trinitrobenzenesulphonic acid in 0.5 ml of 50% (v/v) ethanol. Rats injected with vehicle served as controls. Animals …
Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice
Publication Year: 2002 Source: Clin Immunol PMID: 11890710 DOI: 10.1006/clim.2001.5166
The purpose of the present study was to determine if supplementation of ascorbic acid (AA) to the diet would have a beneficial effect on infectious bursal disease (IBD) vaccination of chickens for protection against infectious bursal disease virus (IBDV) infection. Two hundred forty specific pathogen-free (SPF) chickens were divided into …
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