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Safety of selective cyclooxygenase-2 inhibitors in inflammatory bowel disease
Publication Year: 2002 Source: Am J Gastroenterol PMID: 12008668 DOI: 10.1111/j.1572-0241.2002.05608.x
CD4+ T lymphocytes in the lamina propria (LP) of the gut play a central role in the immune response in inflammatory bowel disease (IBD). CXCR3 is a chemokine receptor expressed on activated T lymphocytes, and a key component for the recruitment of T helper (Th1) effector cells to the site …
Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage
Publication Year: 2002 Source: Gut PMID: 12010883 DOI: 10.1136/gut.50.6.812
OBJECTIVES: Inflammatory bowel disease (IBD) is usually diagnosed as a result of symptoms but occasionally is found during investigation for other conditions. An earlier report from Nottingham had found a high prevalence of previously undetected "asymptomatic" IBD detected as a result of colorectal cancer screening, and the aim of this …
Association of dehydroepiandrosterone sulfate and testosterone deficiency with bone turnover in men with inflammatory bowel disease
Publication Year: 2002 Source: Int J Colorectal Dis PMID: 12014422 DOI: 10.1007/s003840100334
Inflammatory bowel disease (IBD) comprises two chronic, tissue-destructive, clinical entities Crohn disease (CD) and ulcerative colitis (UC) both apparently caused by immunological overreaction (hypersensitivity) to commensal gut bacteria. Under normal conditions the intestinal immune system shows a down-regulating tone ('oral tolerance') against dietary antigens and the indigenous microbiota. This local …
Systemic and local evidence of increased Fas-mediated apoptosis in ulcerative colitis
Publication Year: 2002 Source: Int J Colorectal Dis PMID: 12014424 DOI: 10.1007/s003840100340
The aim of this prospective study was to examine the role of coagulation factor XIII (FXIII) in relation to disease activity in inflammatory bowel disease (IBD) and in giant cell arteritis. Plasma FXIII activity was studied during active and inactive disease in newly diagnosed patients with Crohn's disease (CD; n …
The in vitro anti-inflammatory effects of recombinant anti-CD25 immunotoxin on lamina propria T cells of patients with inflammatory bowel disease are not sufficient to cure experimental colitis in mice
Publication Year: 2002 Source: Int J Colorectal Dis PMID: 12014425 DOI: 10.1007/s003840100336
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T cell receptor delta repertoire in inflamed and noninflamed colon of patients with IBD analyzed by CDR3 spectratyping
Publication Year: 2002 Source: Am J Physiol Gastrointest Liver Physiol PMID: 12016128 DOI: 10.1152/ajpgi.00224.2001
OBJECTIVE: The association between smoking and inflammatory bowel disease (IBD) is well established, but data in Jewish patients in Israel were discrepant. The aim of this study was to examine the smoking habits of Jewish IBD patients in Israel in a large scale, multicenter study. METHODS: Patients with established IBD …
Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors
Publication Year: 2002 Source: Hum Mol Genet PMID: 12019209 DOI: 10.1093/hmg/11.11.1281
BACKGROUND: Azathioprine is an effective treatment for maintaining remission in inflammatory bowel disease (IBD). It is a matter of debate as to whether neutropenia is required during azathioprine therapy to achieve more effective disease remission. We evaluated whether neutropenia during azathioprine therapy reduced relapse rates in IBD patients. PATIENTS AND …
Fine mapping of a quantitative trait locus for twinning rate using combined linkage and linkage disequilibrium mapping
Publication Year: 2002 Source: Genetics PMID: 12019251 DOI: 10.1093/genetics/161.1.373
BACKGROUND: Quantitative determination of pancreatic elastase-1 (E1) in stools has been proposed as a novel, noninvasive test of pancreatic function. The aim of the study was to verify its role in the differential diagnosis of chronic diarrhea. METHODS: E1 was measured in spot stool samples of 50 patients with pancreatic …
Uncoupling of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis in inflammatory bowel disease?
Publication Year: 2002 Source: J Neuroimmunol PMID: 12020963 DOI: 10.1016/s0165-5728(02)00047-4
Looking back at successes and failures in newer approaches to treating IBD, it is tempting--although still difficult--to draw conclusions about pathogenesis. When a therapy proves effective, do clinicians truly know how it works? Even with a therapy as specific as anti-TNF antibody, it is not clear if the benefit is …
Quality of life in paediatric inflammatory bowel disease measured by a generic and a disease-specific questionnaire
Publication Year: 2002 Source: Acta Paediatr PMID: 12022311 DOI: 10.1080/08035250252834049
Tenascin-C is a multifunctional matrix protein that is induced in inflammation and neoplasia. In the colonic mucosa of ulcerative colitis patients tenascin-C indicates tissue repair, and mucosal concentrations are correlated with local disease activity. We prospectively examined the relationship between serum concentrations of tenascin-C parameters of disease activity in surgically …
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