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Small-duct primary sclerosing cholangitis: a long-term follow-up study
Publication Year: 2002 Source: Hepatology PMID: 12029635 DOI: 10.1053/jhep.2002.33202
Extreme sampling of sibling pairs has been shown to be efficient in terms of statistical power and sample sizes (in number of sibling pairs needed to genotype) to detect a quantitative trait locus (QTL) when the residual distribution is normal. In the present study, the efficiency of extreme sampling strategies …
Sex stratification of an inflammatory bowel disease genome search shows male-specific linkage to the HLA region of chromosome 6
Publication Year: 2002 Source: Eur J Hum Genet PMID: 12032734 DOI: 10.1038/sj.ejhg.5200792
Comment in Gastroenterology. 2002 Apr;122(4):1165-7. BACKGROUND & AIMS: Approximately 40% of inflammatory bowel disease (IBD) patients fail to benefit from 6-mercaptopurine (6-MP)/azathioprine (AZA). Recent reports suggest 6-thioguanine nucleotide (6-TGN) levels (>235) independently correlate with remission. An inverse correlation between 6-TGN and thiopurine methyltransferase (TPMT) has been described. The objectives of …
Genomic structure, chromosome mapping and expression analysis of the human AVIL gene, and its exclusion as a candidate for locus for inflammatory bowel disease at 12q13-14 (IBD2)
Publication Year: 2002 Source: Gene PMID: 12034507 DOI: 10.1016/s0378-1119(02)00478-x
In recent years the status of the inflammatory bowel diseases (IBDs) as canonical autoimmune diseases has risen steadily with the recognition that these diseases are, at their crux, abnormalities in mucosal responses to normally harmless antigens in the mucosal microflora and therefore responses to antigens that by their proximity and …
Prevention of psychological distress in persons with inflammatory bowel disease
Publication Year: 2002 Source: Issues Ment Health Nurs PMID: 12036497 DOI: 10.1080/01612840290052596
The proportions of affected sibs sharing 2, 1 or 0 identical by descent parental marker alleles have been shown to conform to the 'triangle constraints' (Suarez, 1978; Holmans, 1993). It has also been shown (Dudoit & Speed, 1999) that the constraints are verified provided certain assumptions hold. In this study …
Detecting gene-gene interactions using affected sib pair analysis with covariates
Publication Year: 2002 Source: Hum Hered PMID: 12037408 DOI: 10.1159/000057987
We carried out a discriminant analysis with identity by descent (IBD) at each marker as inputs, and the sib pair type (affected-affected versus affected-unaffected) as the output. Using simple logistic regression for this discriminant analysis, we illustrate the importance of comparing models with different number of parameters. Such model comparisons …
Construction of a confidence set of markers for the location of a disease gene using affected sib pair data
Publication Year: 2002 Source: Hum Hered PMID: 12037409 DOI: 10.1159/000057988
The strongest risk factor for developing inflammatory bowel disease (IBD) is having a relative with the disease. Familial IBD may be one homogeneous subgroup, phenotypically different from sporadic IBD. Several observations support a role for familiarity in disease site and behavior, particularly in Crohn's disease (CD), but published findings do …
The conversion of redox status of peritoneal macrophages during pathological progression of spontaneous inflammatory bowel disease in Janus family tyrosine kinase 3(-/-) and IL-2 receptor gamma(-/-) mice
Publication Year: 2002 Source: Int Immunol PMID: 12039914 DOI: 10.1093/intimm/dxf031
The role of nitric oxide (NO) in the pathophysiology of inflammatory bowel diseases (IBD) is controversially discussed. The aim of the present study was to investigate the role of NO inhibition in the acute phase of rat 2,4,6-trinitrobenzenesulphonic acid (TNB)-colitis. To inhibit NO synthesis we used aminoguanidine (AG) as a …
Probiotics in clinical conditions
Publication Year: 2002 Source: Clin Rev Allergy Immunol PMID: 12043384 DOI: 10.1007/s12016-002-0011-0
Material innovations are reviewed within the context of ongoing biomechanical developments that relate the critical contact angle of second-order angulation (theta c) to the overall resistance to sliding (RS). As a science in its embryonic stage of development, RS is partitioned into classical friction (FR), elastic binding (BI), and physical …
Serum interleukin-18 concentrations in patients with inflammatory bowel disease
Publication Year: 2002 Source: J Immunother PMID: 12048353 DOI: 10.1097/00002371-200203001-00010
Haseman and Elston (1972) developed a robust regression method for the detection of linkage between a marker and a quantitative trait locus (QTL) using sib pair data. The principle underlying this method is that the difference in phenotypes between pairs of sibs becomes larger as they share a decreasing number …
Increased expression of tumor necrosis factor-alpha messenger RNA in the intestinal mucosa of inflammatory bowel disease, particularly in patients with disease in the inactive phase
Publication Year: 2002 Source: J Gastroenterol PMID: 12051533 DOI: 10.1007/s005350200048
Some patients with inflammatory bowel disease (IBD) have chronic cholestasis and hepatic histology compatible with primary sclerosing cholangitis (PSC) but normal findings on cholangiography. These patients with small-duct PSC have remained largely unstudied. Our aim was to determine the prevalence and long-term outcomes of patients with small-duct PSC. Eighteen patients …
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