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[Pancreatic involvement in inflammatory bowel diseases in children]
Publication Year: 2002 Source: Arch Pediatr PMID: 12053540 DOI: 10.1016/s0929-693x(01)00828-4
Comment in Am J Gastroenterol. 2000 Jul;95(7):1849-50. Assessment of disease activity in inflammatory bowel disease (IBD), i.e., ulcerative colitis (UC) and Crohn's disease (CD), is done using clinical parameters and various biological disease markers. Ideally, a disease marker must: be able to identify individuals at risk of a given disorder, …
Young adults' perceptions of living with chronic inflammatory bowel disease
Publication Year: 2002 Source: Gastroenterol Nurs PMID: 12055376 DOI: 10.1097/00001610-200205000-00002
Inflammatory bowel disease (IBD) is now recognized as a common chronic disease affecting children and adolescents. This article will review recent advances made in the fields of genetics, epidemiology, gut ecology, and immunology regarding the etiopathogenesis of IBD, with particular emphasis on the contributions made by pediatric studies. Areas where …
Enterococcus faecalis induces inflammatory bowel disease in interleukin-10 knockout mice
Publication Year: 2002 Source: Am J Pathol PMID: 12057927 DOI: 10.1016/S0002-9440(10)61172-8
BACKGROUND: Both genetic and microbial factors are thought to play a role in the development of inflammatory bowel disease (IBD): however, no causative microbial agent has been clearly defined for humans or animals. Normal flora or previously unrecognized intestinal pathogens may contribute to the development of disease in susceptible hosts. …
Incidence of inflammatory bowel disease in children in southeastern Norway: a prospective population-based study 1990-94
Publication Year: 2002 Source: Scand J Gastroenterol PMID: 12059055 DOI: 10.1080/00365520252903080
BACKGROUND/AIMS: Cigarette smoking is closely related to the development and recurrence of inflammatory bowel disease (IBD). The present study aimed to investigate the underlying mechanisms of the adverse action of cigarette smoke (CS) exposure on trinitrobenzene sulfonic acid (TNBS)-induced IBD. METHODS: Rats were preexposed to CS once daily for 4 …
Increased expression of inducible nitric oxide synthase in circulating monocytes from patients with active inflammatory bowel disease
Publication Year: 2002 Source: Scand J Gastroenterol PMID: 12059056 DOI: 10.1080/00365520252903099
Comment in J Clin Gastroenterol. 1999 Sep;29(2):115-6. Intravenous cyclosporine therapy followed by oral cyclosporine therapy reduce the need for urgent surgery in steroid-refractory inflammatory bowel disease (IBD). Our objective is to report short- and long-term results of cyclosporine therapy in IBD patients. Thirteen patients with steroid-refractory IBD, seven patients with …
Na+/H+ exchanger blockade inhibits enterocyte inflammatory response and protects against colitis
Publication Year: 2002 Source: Am J Physiol Gastrointest Liver Physiol PMID: 12065299 DOI: 10.1152/ajpgi.00015.2002
BACKGROUND AND AIMS: Persistent inflammation observed in inflammatory bowel disease may be the consequence of an increased or aberrant immune response to normal gut constituents or an overall immune dysregulation and imbalance. Cytokines play an important role in immune regulation and interleukin 18 (IL-18) is one such cytokine that has …
A survey of infectious agents as risk factors for primary sclerosing cholangitis: are Chlamydia species involved?
Publication Year: 2002 Source: Eur J Gastroenterol Hepatol PMID: 12072598 DOI: 10.1097/00042737-200206000-00009
BACKGROUND: Interleukin-8 (IL-8) is an important cytokine for recruitment and activation of polymorphonuclear neutrophils (PMNs), cells that are abundant in the intestinal lesions of ulcerative colitis (UC) and Crohn's disease (CD). The present investigation was conducted to evaluate intestinal IL-8 concentration and IL-8 gene expression in parallel in inflammatory bowel …
Inflammatory bowel disease and pregnancy
Publication Year: 2002 Source: Int J Colorectal Dis PMID: 12073069 DOI: 10.1007/s00384-001-0365-4
During the past decade, a tremendous wealth of information regarding the pathogenesis, genetics, and therapy of IBD has been discovered. Judging by the number of new publications published every month in scientific journals and the great enthusiasm at scientific meetings, this outstanding pace surely will continue. In the near future, …
Abrogated lymphocyte infiltration and lowered CD14 in dextran sulfate induced colitis in mice treated with p65 antisense oligonucleotides
Publication Year: 2002 Source: Int J Colorectal Dis PMID: 12073070 DOI: 10.1007/s00384-001-0366-3
Comment in Acta Paediatr. 2002;91(3):265-6. This study assessed the impact of inflammatory bowel disease (IBD) on the health-related quality of life (HRQoL) of children and adolescents, using both a generic and a disease-specific instrument. Three questionnaires were sent to all patients (8-18 y old) from the database of two large …
Investigation of HLA-DPA1 genotypes as predictors of inflammatory bowel disease in the German, South African, and South Korean populations
Publication Year: 2002 Source: Int J Colorectal Dis PMID: 12073072 DOI: 10.1007/s00384-001-0382-3
Comment in Rev Gastroenterol Disord. 2002 Fall;2(4):202-4. This report investigates the influence of liver transplantation and concomitant immunosuppression on the course of progression of inflammatory bowel disease (IBD) and discusses statistical methodology appropriate for such settings. The data on 303 patients who underwent liver transplantation for primary sclerosing cholangitis (PSC) …
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