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Regression of Peyer's patches in G alpha i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis
Publication Year: 2002 Source: Gut PMID: 12171962 DOI: 10.1136/gut.51.3.392
Tumour necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine which is shed in its soluble form by a disintegrin and metalloproteinase (ADAM) called TNF-alpha convertase (TACE; ADAM17). TNF-alpha plays a role in inflammatory bowel disease (IBD) and is involved in the expression of inducible nitric oxide synthase (iNOS) which has also …
Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis
Publication Year: 2002 Source: Gut PMID: 12171963 DOI: 10.1136/gut.51.3.398
BACKGROUND: Endothelial MAdCAM-1 (mucosal addressin cell adhesion molecule-1) expression is associated with the oxidant-dependent induction and progress of inflammatory bowel disease (IBD). Melatonin, a relatively safe, potent antioxidant, has shown efficacy in several chronic injury models may limit MAdCAM-1 expression and therefore have a therapeutic use in IBD. METHODS: We …
Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism
Publication Year: 2002 Source: Pharmacogenetics PMID: 12172211 DOI: 10.1097/00008571-200208000-00003
A role for cytokine regulated proteins in epithelial cells has been suggested in the pathogenesis of inflammatory bowel diseases (IBD). The aim of this study was to identify such cytokine regulated targets using a proteomic functional approach. Protein patterns from (35)S-radiolabeled homogenates of cultured colon epithelial cells were compared before …
Faecal calprotectin: a marker of inflammation throughout the intestinal tract
Publication Year: 2002 Source: Eur J Gastroenterol Hepatol PMID: 12172400 DOI: 10.1097/00042737-200208000-00002
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The probability that similar haplotypes are identical by descent
Publication Year: 2002 Source: Ann Hum Genet PMID: 12174211 DOI: 10.1017/S0003480002001100
BACKGROUND AND AIM: Calcium oxalate renal stones (RS) and hyperoxaluria are common in patients with inflammatory bowel disease (IBD). The absence of intestinal oxalate degrading bacteria, Oxalobacter formigenes, may cause hyperoxaluria in IBD. The aim of the present study was to examine: (i) the colonization of O. formigenes in patients …
Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis
Publication Year: 2002 Source: Life Sci PMID: 12175704 DOI: 10.1016/s0024-3205(02)01923-9
Comment in Am J Gastroenterol. 2002 Apr;97(4):783-5. OBJECTIVES: Nonsteroidal anti-inflammatory drugs (NSAIDs) are relatively contraindicated in patients with inflammatory bowel disease (IBD) for fear of disease aggravation. Cyclooxygenase-2 inhibitors have fewer GI side effects than traditional NSAIDs in unselected patients. We report the safety of these agents in patients with …
Hepatic leukocyte recruitment in a model of acute colitis
Publication Year: 2002 Source: Am J Physiol Gastrointest Liver Physiol PMID: 12181168 DOI: 10.1152/ajpgi.00462.2001
Inflammatory bowel disease (IBD) is a chronic debilitating disorder. Measures of quality of life are only available for adult patient populations. We developed a new disease-specific health-related quality of life instrument in Dutch for pediatric patients with IBD, called Impact-II (NL). We translated and strongly modified the original (Canadian) Impact …
Murine monoclonal anti-tNF antibody administration has a beneficial effect on inflammatory bowel disease that develops in IL-10 knockout mice
Publication Year: 2002 Source: Dig Dis Sci PMID: 12184521 DOI: 10.1023/a:1016476024293
OBJECTIVES: The aims of this retrospective study were 1) to determine the ability of single-toxin assays for Clostridium difficile to detect infection among pediatric patients with inflammatory bowel disease (IBD) and 2) to determine the toxin assays routinely used by pediatric tertiary care hospitals in the United States. METHODS: Stool …
N-acetyltransferase 2 genotype-related sulfapyridine acetylation and its adverse events
Publication Year: 2002 Source: Biol Pharm Bull PMID: 12186410 DOI: 10.1248/bpb.25.1058
A genetic component in the etiology of inflammatory bowel disease (IBD) has clearly been demonstrated by epidemiological and genetic linkage studies. Linkage to IBD on proximal Chromosome (Chr) 16p is well established and replicated. A stratification experiment showed that the recent identification of a disease gene on the q arm …
Inflammatory bowel disease in children 5 years of age and younger
Publication Year: 2002 Source: Am J Gastroenterol PMID: 12190168 DOI: 10.1111/j.1572-0241.2002.05915.x
Comment in Am J Gastroenterol. 2002 Nov;97(11):2920; author reply 2920-1. OBJECTIVES: Information on the occurrence and frequency of pulmonary involvement in patients with inflammatory bowel disease (IBD) is inconsistent. The aim of this prospective study was to determine the frequency and type of pulmonary dysfunction in patients with IBD. METHODS: …
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