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Activity related increase of exhaled nitric oxide in Crohn's disease and ulcerative colitis: a manifestation of systemic involvement?
Publication Year: 2002 Source: Respir Med PMID: 12194639 DOI: 10.1053/rmed.2002.1312
Activated monocytes with increased expression of proinflammatory cytokines play a major role in inflammatory bowel disease (IBD). Immunoregulatory cytokines such as IL-4 and IL-10 can effectively suppress the proinflammatory response of activated monocytes. IL-13 is a recently described antiinflammatory agent in vitro. The aim of our study was to determine …
Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes
Publication Year: 2002 Source: Gastroenterology PMID: 12198697 DOI: 10.1053/gast.2002.35396
BACKGROUND: Patients presenting to gastroenterology clinics with symptoms suggestive of lower-bowel disorders often require extensive investigation to differentiate functional from organic disease. C-reactive protein (CRP) is a sensitive marker of systemic inflammation. Levels of CRP are frequently raised in cases of inflammatory bowel disease (IBD). However, using conventional assays, not …
The effects of drugs modulating K(+) transport on Rb(+) uptake and distribution in pig hearts following regional ischemia: (87)Rb MRI study
Publication Year: 2002 Source: NMR Biomed PMID: 12203226 DOI: 10.1002/nbm.777
BACKGROUND & AIMS: We investigated factors that affect long-term outcomes in Crohn's disease (CD). METHODS: We performed a retrospective study of 3403 patients with CD, diagnosed between 1988 and 2008 in Manitoba, Canada. Subjects were assigned to cohorts based on diagnosis year: cohort I (before 1996), cohort II (1996-2000), or …
Quantitative analysis for human glucocorticoid receptor alpha/beta mRNA in IBD
Publication Year: 2002 Source: Biochem Biophys Res Commun PMID: 12207914 DOI: 10.1016/s0006-291x(02)02030-2
Comment in Pharmacogenetics. 2002 Aug;12(6):421-3. Pharmacogenomics J. 2003;3(2):66-8. The efficacy of the immunosuppressants azathioprine and 6-mercaptopurine has been well established in the therapy of inflammatory bowel diseases (IBD). However, its use has been complicated by a high incidence of serious adverse drug reactions such as hematotoxicity, hepatotoxicity, pancreatitis and gastrointestinal …
Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: current perspectives
Publication Year: 2002 Source: Pharmacol Res PMID: 12208114 DOI: 10.1016/s1043-6618(02)00033-6
Once regarded as medical curiosities, ulcerative colitis and Crohn's disease have achieved a remarkable change in status recently and today are among the more compelling of all human illnesses. The cause(s) of inflammatory bowel disease (IBD) are not known. Genetic, environmental, microbial, and immunologic factors are involved, but the precise …
How common is celiac disease in Eastern Saudi Arabia?
Publication Year: 2002 Source: Ann Saudi Med PMID: 17146251 DOI: 10.5144/0256-4947.2002.315
When conducting genetic studies for complex traits, large samples are commonly required to detect any of the number of genes with relatively low effect thought to underly such traits. This is because, in contrast to monogenic diseases, complex traits typically result from a number of different genetic pathways (genetic heterogeneity) …
Update on genetics of inflammatory bowel disease
Publication Year: 2002 Source: Curr Opin Gastroenterol PMID: 17033314 DOI: 10.1097/00001574-200207000-00003
Despite many years of intensive research the pathogenesis of inflammatory bowel diseases is still enigmatic. All efforts to identify the cause of Crohn's disease and ulcerative colitis in a dysregulation of specific immune mechanisms have failed. This review presents a novel pathogenetic concept, based on the expression of natural mucosal …
Epidemiology of inflammatory bowel disease
Publication Year: 2002 Source: Curr Opin Gastroenterol PMID: 17033315 DOI: 10.1097/00001574-200207000-00004
OBJECTIVE: Patients with ankylosing spondylitis (AS) and approximately 50% of their first-degree relatives may have a genetic abnormality that results in subclinical intestinal inflammation. This study was undertaken to examine the familial occurrence and cosegregation of AS and inflammatory bowel disease (IBD) in order to determine whether there is a …
Immunopathogenesis of inflammatory bowel disease
Publication Year: 2002 Source: Curr Opin Gastroenterol PMID: 17033316 DOI: 10.1097/00001574-200207000-00005
Familial aspects of inflammatory bowel disease (IBD) were assessed as part of an age and sex matched case control study of 91 children with IBD and 131 controls. The prevalence of IBD in family members of the children was studied, the affected side (mother's side or father's side) of the …
Osteoporosis and other complications of inflammatory bowel disease
Publication Year: 2002 Source: Curr Opin Gastroenterol PMID: 17033317 DOI: 10.1097/00001574-200207000-00006
BACKGROUND & AIMS: Familial colorectal cancer (CRC) is a risk factor for CRC in healthy individuals and, as indicated by case-control studies, possibly in ulcerative colitis. Little is known about the cancer risk in familial inflammatory bowel disease (IBD). We assessed the significance of familial CRC, or IBD, on the …
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