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Advances in the medical therapy of inflammatory bowel disease
Publication Year: 2002 Source: Curr Opin Gastroenterol PMID: 17033318 DOI: 10.1097/00001574-200207000-00007
Genomic technologies offer new approaches to the investigation of etiology and pathophysiology of inflammatory bowel disease (IBD). Several areas of application for these new technologies are possible. One such application is the search for gene variations predisposing to the development of the disorder in multiply-affected families. Genome-wide linkage studies have …
Pediatric inflammatory bowel disease: clinical and therapeutic aspects
Publication Year: 2001 Source: Curr Opin Gastroenterol PMID: 17031182 DOI: 10.1097/00001574-200107000-00009
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Induction of mucosal immune responses by bacteria and bacterial components
Publication Year: 2001 Source: Curr Opin Gastroenterol PMID: 17031218 DOI: 10.1097/00001574-200111000-00013
We report on the use of glass substrates for the infrared spectroscopic analysis of dried serum, amniotic fluid, and synovial fluid films. New analytical applications of infrared spectroscopy are emerging rapidly, spurred largely by ever-improving instrumentation, combined with the widespread availability of powerful chemometric methods. We have recently begun to …
Expression of B7 costimulatory molecules by cells infiltrating the colon in experimental colitis induced by oral dextran sulfate sodium in the mouse
Publication Year: 2001 Source: J Gastroenterol Hepatol PMID: 11903740 DOI: 10.1046/j.1440-1746.2001.02558.x
OBJECTIVES: Recent epidemiological studies suggest that mortality rates for inflammatory bowel disease (IBD) are similar to those of the general population. However, most of this work has been done in referred populations or larger urban centers. We intended to estimate mortality rates for ulcerative colitis (UC) and Crohn's disease (CD) …
Chronic narcotic use in inflammatory bowel disease patients: prevalence and clinical characteristics
Publication Year: 2001 Source: J Gastroenterol Hepatol PMID: 11903741 DOI: 10.1046/j.1440-1746.2001.02468.x
Comment in Am J Gastroenterol. 2002 Apr;97(4):1061-2. OBJECTIVE: The aim of this study was to determine the outcome of cytomegalovirus (CMV) infections complicating the course of inflammatory bowel disease (IBD). METHODS: The records and clinical courses were reviewed for all IBD patients who were evaluated at the IBD Center of …
Reduced serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in adults with inflammatory bowel disease
Publication Year: 2001 Source: Growth Horm IGF Res PMID: 11914023 DOI: 10.1054/ghir.2001.0248
Numerous extraintestinal manifestations in various organ systems have been reported to be associated with inflammatory bowel disease (IBD). Aim of the present paper was to evaluate the frequency of cutaneous manifestations in Crohn's disease (CD) and ulcerative colitis (UC) with respect to their location, the activity and location of the …
Inflammatory bowel disease is associated with a novel promoter polymorphism of natural resistance-associated macrophage protein 1 (NRAMP1) gene
Publication Year: 2001 Source: Tissue Antigens PMID: 11929588 DOI: 10.1034/j.1399-0039.2001.580606.x
BACKGROUND: Health Related Quality of Life (HRQoL) is an important outcome measure in Inflammatory Bowel Disease (IBD). The aim of our study was to assess HRQoL in a population of 135 Greek patients with IBD. METHODS: A cohort of 135 patients with IBD, 81 with ulcerative colitis (UC) and 54 …
Modification of enteral diets in inflammatory bowel disease
Publication Year: 2001 Source: Proc Nutr Soc PMID: 12069398 DOI: 10.1079/pns2001120
Even a minor decrease in birthweight predisposes to adult disease. Inflammatory bowel disease (IBD) in the mother is a risk factor for low birthweight and preterm infants. This study investigated the effect of IBD in the mother or father, adjusting for confounders, on the newborn infant, with the focus on …
Fecal calprotectin as an index of intestinal inflammation
Publication Year: 2001 Source: Drugs Today (Barc) PMID: 12783101 DOI: 10.1358/dot.2001.37.2.614846
The chronic inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are recognized as important causes of gastrointestinal disease in children and adults. In this review we delineate the clinical manifestations and diagnostic features of IBD. In addition, we summarize important recent advances in our understanding of the immune mediators …
The role of biological therapy in inflammatory bowel disease
Publication Year: 2001 Source: Drugs Today (Barc) PMID: 12783103 DOI: 10.1358/dot.2001.37.2.614848
Comment in Gut. 2004 Jul;53(7):1058. BACKGROUND AND AIMS: One major problem in the management of steroid refractory attacks of patients with inflammatory bowel disease (IBD) is the establishment of a rapidly acting immunosuppressive regimen. Based on its well known efficacy in systemic vasculitis, intravenous cyclophosphamide pulse therapy was used in …
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