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Mannan-binding lectin (MBL) gene polymorphisms in ulcerative colitis and Crohn's disease
Publication Year: 2001 Source: Genes Immun PMID: 11607788 DOI: 10.1038/sj.gene.6363784
We evaluated free plasma levels of protein S, a natural anticoagulant factor, the prevalence of anti-protein S antibodies, a possible cause of protein S deficiency, and their correlation with anti-phospholipid antibodies in 53 patients with inflammatory bowel disease (IBD) and 53 age- and sex-matched controls. Mean free plasma protein S …
Modeling of HLA class II susceptibility to Type I diabetes reveals an effect associated with DPB1
Publication Year: 2001 Source: Genet Epidemiol PMID: 11668578 DOI: 10.1002/gepi.1030
Comment in Am J Gastroenterol. 2001 Aug;96(8):2296-8. OBJECTIVE: Inflammatory bowel disease (IBD)-associated anemia responds to i.v. iron therapy. However, because of concurrent chronic inflammation, some patients do not respond adequately. Erythropoietin therapy has been shown to be effective in the latter cohort. Our goal was to find parameters that can …
Effects of flow and energy metabolism on injury and Rb(+) uptake in pig hearts: an (87)Rb and (31)P NMR study
Publication Year: 2001 Source: Magn Reson Med PMID: 11675649 DOI: 10.1002/mrm.1283
Ion flux studies were performed on Langendorff-perfused rat hearts using 87Rb, 7Li and 23Na NMR at 36, 20 and 10 degreesC, and at constant extracellular pH (7.40). Using 31P NMR, the intracellular pH was estimated and the high energy phosphate content monitored. Compared to 36 degreesC (k=0.044+/-0.015 min-1), our measurements …
Isotretinoin-induced inflammatory bowel disease in an adolescent
Publication Year: 2001 Source: Ann Pharmacother PMID: 11675849 DOI: 10.1345/aph.10368
A prospective study was undertaken throughout Wales over the period from 1 January 1995 to 30 March 1997, to determine the incidence of childhood inflammatory bowel disease (IBD). Thirty-eight (24 male) new cases of IBD were reported. Twenty (16 male) of the reported cases had Crohn's disease, 11 (5 male) …
Azathioprine treatment and male fertility in inflammatory bowel disease
Publication Year: 2001 Source: Gastroenterology PMID: 11677195 DOI: 10.1053/gast.2001.28692
OBJECTIVE: Endomysial autoantibodies (EmA) are specific for celiac disease. The target antigen has been identified as tissue tranglutaminase (tTG). Our aim was to study the accuracy of a newly developed enzyme-linked immunosorbent assay (ELISA) for easy detection of tTG autoantibodies. METHODS: Thirty-one sera from patients with histologically proven celiac disease …
Inflammatory bowel disease: pathogenesis and targets for therapeutic interventions
Publication Year: 2001 Source: Acta Physiol Scand PMID: 11678739 DOI: 10.1046/j.1365-201X.2001.00905.x
Comment on Eur J Gastroenterol Hepatol. 1999 Sep;11(9):1001-5. Mild arthritis/arthralgia is the most frequent extraintestinal manifestation in inflammatory bowel disease (IBD) and has been reported to occur in 10-35% of patients in different studies. A classification of peripheral arthropathy in relation to inflammatory bowel disease has recently been proposed. Type …
Differentiation of antineutrophil nuclear antibodies in inflammatory bowel and autoimmune liver diseases from antineutrophil cytoplasmic antibodies (p-ANCA) using immunofluorescence microscopy
Publication Year: 2001 Source: Clin Exp Immunol PMID: 11678897 DOI: 10.1046/j.1365-2249.2001.01649.x
A population of CD4+ T cells with TCR beta-chain without TCR alpha-chain (CD4+, betabeta T cells) producing Th2-type cytokines increased in the mucosal and peripheral tissues of TCR alpha-chain deficient mice with inflammatory bowel disease (IBD). Analysis of TCR-beta immunoprecipitates by two-dimensional electrophoresis and RT-PCR revealed TCR of the CD4+ …
Preventive effects of Bifidobacterium- and Lactobacillus-fermented milk on the development of inflammatory bowel disease in senescence-accelerated mouse P1/Yit strain mice
Publication Year: 2001 Source: Digestion PMID: 11684822 DOI: 10.1159/000048846
OBJECTIVE: Increasing evidence suggests that nitric oxide participates in the pathophysiology of intestinal barrier function/dysfunction and inflammation. Increases in inducible nitric oxide synthase (iNOS) mRNA and protein expression have been observed in colonic mucosal biopsies of adults with inflammatory bowel disease (IBD). It is unclear whether iNOS induction is specific …
Absence of a genetic association between IL-1RN and IL-1B gene polymorphisms in ulcerative colitis and Crohn disease in multiple populations from northeast England
Publication Year: 2001 Source: Scand J Gastroenterol PMID: 11686217 DOI: 10.1080/00365520152584806
BACKGROUND: Primary sclerosing cholangitis (PSC), which is a progressive cholestatic liver disease of unknown etiology, is strongly correlated with inflammatory bowel disease (IBD). GOALS: To determine the prevalence and describe the characteristics of PSC in patients with IBD in Turkey. STUDY: We determined the prevalence of PSC in patients with …
Serum tenascin-C is an indicator of inflammatory bowel disease activity
Publication Year: 2001 Source: Int J Colorectal Dis PMID: 11686525 DOI: 10.1007/s003840100312
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