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FR167653, a potent suppressant of interleukin-1 and tumor necrosis factor-alpha production, ameliorates colonic lesions in experimentally induced acute colitis
Publication Year: 2001 Source: J Gastroenterol Hepatol PMID: 11686836 DOI: 10.1046/j.1440-1746.2001.02584.x
OBJECTIVE: Alteration of mucosal and systemic immune responses may play an important role in the pathogenesis of inflammatory bowel disease (IBD). The aim of this study was to evaluate natural immune responses (i.e., phagocytosis, killing, and antibacterial activity), serum autoantibodies (antineutrophil cytoplasmic antibodies [ANCA] and anti-lactoferrin [LF] antibodies), and plasma …
Immunological basis of inflammatory bowel disease: role of the microcirculation
Publication Year: 2001 Source: Microcirculation PMID: 11687942 DOI: 10.1038/sj/mn/7800095
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology that is progressive in most symptomatic patients, advancing toward cirrhosis and liver failure. Liver transplantation is the only therapeutic option for patients with end stage liver disease resulting from this disorder. The results of transplantation for PSC …
(99m)Tc antigranulocyte monoclonal antibody imaging for the detection and assessment of inflammatory bowel disease newly diagnosed by colonoscopy in children
Publication Year: 2001 Source: Pediatr Radiol PMID: 11692237 DOI: 10.1007/s002470100537
OBJECTIVES: The objectives of this study were to compare the psychological status of patients in active and inactive disease states, to assess social support, and to identify correlates of psychological distress in patients with inflammatory bowel disease (IBD). METHODS: This cross-sectional study was conducted in 200 patients (mean age 36.7 …
CD40 and CD86 upregulation with divergent CMRF44 expression on blood dendritic cells in inflammatory bowel diseases
Publication Year: 2001 Source: Am J Gastroenterol PMID: 11693331 DOI: 10.1111/j.1572-0241.2001.04686.x
Recent studies have demonstrated that the complement system participates in the regulation of T cell functions. To address the local biosynthesis of complement components in inflammatory bowel disease (IBD) mucosa, we investigated C3 and interleukin (IL)-17 mRNA expression in mucosal samples obtained from patients with IBD. The molecular mechanisms underlying …
Inflammatory cytokines and mucosal injury
Publication Year: 2001 Source: J Natl Cancer Inst Monogr PMID: 11694562 DOI: 10.1093/oxfordjournals.jncimonographs.a003435
Inflammatory bowel diseases (IBD) are multifactorial traits involving both environmental and genetic factors. In order to identify the IBD susceptibility genes, two groups of strategies have been developed. In the candidate gene approach, a specific hypothesis is tested by usually investigating the prevalence of specific alleles in groups of affected …
Update on the genetics of inflammatory bowel disease
Publication Year: 2001 Source: Curr Gastroenterol Rep PMID: 11696282 DOI: 10.1007/s11894-001-0065-9
Surgery continues to be a central component in the treatment of patients with inflammatory bowel disease (IBD). The most important aspect of caring for patients with IBD is a close and ongoing interaction between the surgeon and gastroenterologist both before and after surgery. Surgery in patients with chronic ulcerative colitis …
Extraintestinal manifestations of inflammatory bowel disease
Publication Year: 2001 Source: Curr Gastroenterol Rep PMID: 11696285 DOI: 10.1007/s11894-001-0068-6
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Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide
Publication Year: 2001 Source: J Exp Med PMID: 11696587 DOI: 10.1084/jem.194.9.1207
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6-mercaptopurine metabolite levels in children with inflammatory bowel disease
Publication Year: 2001 Source: J Pediatr Gastroenterol Nutr PMID: 11698762 DOI: 10.1097/00005176-200110000-00006
BACKGROUND: miR-143 and miR-145 are believed to function as colon cancer tumor suppressors, as they inhibit colon cancer cell growth and are downregulated in sporadic colonic tumors. We speculated that miR-143 and miR-145 might also be downregulated and contribute to malignant transformation of colonic epithelium in longstanding ulcerative colitis (UC). …
Unusual presentation of Hodgkin's disease mimicking inflammatory bowel disease
Publication Year: 2001 Source: Leuk Lymphoma PMID: 11699419 DOI: 10.3109/10428190109064611
Comment on Gut. 2006 May;55(5):671-80. Transforming growth factor β (TGF‐β) and interleukin 2 may be involved in IBD peripheral regulatory T cell pathophysiology, raising the possibility of therapeutic application of TGF‐β induced regulatory T cells in IBD patients
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