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Selection and subsequent analysis of sib pair data for QTL detection
Publication Year: 2001 Source: Genet Res PMID: 11732095 DOI: 10.1017/s0016672301005225
Inflammatory bowel disease (IBD) follows a multigenic mode of inheritance, encompassing the clinically discrete phenotypes of ulcerative colitis (UC) and Crohn's disease (CD). The risk of malignant transformation of the colon increases with the duration and extent of IBD and is particularly high for patients with a longstanding history of …
Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins
Publication Year: 2001 Source: Am J Pathol PMID: 11733350 DOI: 10.1016/S0002-9440(10)63051-9
To investigate the role of IFN-gamma in the immunopathogenesis of inflammatory bowel disease (IBD), severe combined immunodeficient (SCID) mice were transplanted with in vitro activated CD4+ T cells from either wild-type (WT) or IFN-gamma-deficient (IFN-gammaKO) BALB/c mice. In vitro, the two types of T cells displayed comparable proliferation rates and …
Decreased CD44v6 expression in lamina propria lymphocytes of patients with inflammatory bowel disease
Publication Year: 2001 Source: Exp Mol Pathol PMID: 11733944 DOI: 10.1006/exmp.2001.2404
Inflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal inflammation, typically starting in early adulthood. IBD is subdivided into two subtypes, on the basis of clinical and histologic features: Crohn disease and ulcerative colitis (UC). Previous genomewide searches identified regions harboring susceptibility loci on chromosomes 1, 3, 4, …
Measles vaccination and inflammatory bowel disease: controversy laid to rest?
Publication Year: 2001 Source: Drug Saf PMID: 11735650 DOI: 10.2165/00002018-200124130-00001
Traditional fine-mapping approaches in mouse genetics that go from a linkage region to a candidate gene are very costly and time consuming. Shared ancestry regions, along with the combination of genetics and genomics approaches, provide a powerful tool to shorten the time and effort required to identify a causative gene. …
MHC class I chain-like gene A (MICA) and its associations with inflammatory bowel disease and peripheral arthropathy
Publication Year: 2001 Source: Clin Exp Immunol PMID: 11737059 DOI: 10.1046/j.1365-2249.2001.01662.x
Comment in Inflamm Bowel Dis. 2009 Apr;15(4):641-2. BACKGROUND: We sought to determine nationwide, population-based trends in rates of Clostridium difficile (C. difficile) infection among hospitalized inflammatory bowel disease (IBD) patients in the United States, and to determine its mortality and economic impact. METHODS: We analyzed discharge records from the Nationwide …
Inflammatory bowel disease associated with immune thrombocytopenic purpura in children
Publication Year: 2001 Source: J Pediatr Gastroenterol Nutr PMID: 11740233 DOI: 10.1097/00005176-200111000-00013
BACKGROUND: Immunocompromised travelers to developing countries are thought to have symptomatic infectious diseases more often and longer than non-immunocompromised travelers. Evidence for this is lacking. This study evaluates whether immunocompromised short-term travelers are at increased risk of diseases. METHODS: A prospective study was performed between October 2003 and May 2010 …
Association of HLA-DR genotypes and IL-1ra gene polymorphism with treatment failure of budesonide and disease patterns in Crohn's disease
Publication Year: 2001 Source: Eur J Gastroenterol Hepatol PMID: 11742191 DOI: 10.1097/00042737-200112000-00006
Comment in J Pediatr Gastroenterol Nutr. 2001 Jul;33(1):11-3. BACKGROUND: Calprotectin is an abundant neutrophil protein, which is extremely stable in feces. This study aimed to validate fecal calprotectin as a marker of bowel inflammation against invasive measures in children with inflammatory bowel disease (IBD), including colitis and small bowel Crohn …
Prediction of identity by descent probabilities from marker-haplotypes
Publication Year: 2001 Source: Genet Sel Evol PMID: 11742632 DOI: 10.1186/1297-9686-33-6-605
Extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD) occur rather frequently and may be found in up to 30% of patients. However, surprisingly few randomized, controlled studies have been conducted that were specifically aimed at the treatment of EIM of IBD patients. Therefore, most therapies of EIM are empiric or …
Immunomodulation of experimental colitis: the role of NK1.1 liver lymphocytes and surrogate antigens--bystander effect
Publication Year: 2001 Source: J Pathol PMID: 11745683 DOI: 10.1002/path.974
Inflammatory bowel disease (IBD) is characterized by altered immunoregulation and augmented intestinal synthesis of nitric oxide. The purpose of this study was to determine the effects of exogenous IL-4, introduced by a recombinant human type 5 adenovirus (Ad5) vector, on the tissue injury associated with an experimental model of colonic …
Expression of macrophage-colony stimulating factor in normal and inflammatory bowel disease intestine
Publication Year: 2001 Source: J Pathol PMID: 11745698 DOI: 10.1002/path.991
BACKGROUND: Dipeptidyl peptidase IV (DP IV, CD26), a serine protease with broad tissue distribution and known activity in serum, participates in T cell activation and promotes a Th1 cytokine response, a function in part attributable to its enzymatic activity. We hypothesized that the activity of DP IV in serum and …
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