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Treatment of inflammatory bowel disease in childhood
Publication Year: 2001 Source: Scand J Gastroenterol Suppl PMID: 11768561 DOI: 10.1080/003655201753265109
BACKGROUND: omega-Oxidation is regarded as the major pathway for leukotriene B4 (LTB4) metabolism. Very little is known about it in colonic mucosa with inflammatory bowel disease (IBD). METHODS: We investigated the metabolic ratio of omega-oxidation to LTB4 biosynthesis in colonic mucosa from patients with IBD and control subjects. After incubation …
Clinical perspectives--biologics in IBD: What's all the fuss?
Publication Year: 2001 Source: Can J Gastroenterol PMID: 11773946 DOI: 10.1155/2001/605398
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Quality of health care in inflammatory bowel disease: development of a reliable questionnaire (QUOTE-IBD) and first results
Publication Year: 2001 Source: Am J Gastroenterol PMID: 11774945 DOI: 10.1111/j.1572-0241.2001.05334.x
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Use of pharmaceuticals by inflammatory bowel disease patients: a population-based study
Publication Year: 2001 Source: Am J Gastroenterol PMID: 11774948 DOI: 10.1111/j.1572-0241.2001.05255.x
BACKGROUND AND OBJECTIVE: In recent decades, there has been a significant increase in the incidence of inflammatory bowel disease (IBD). It has yet to be established whether the manifestations of IBD are similar in paediatric and adult ages. The objective of this study was to compare the phenotypic expression of …
Platelet-derived growth factor and its receptors are expressed in areas of both active inflammation and active fibrosis in inflammatory bowel disease
Publication Year: 2001 Source: Tohoku J Exp Med PMID: 11780721 DOI: 10.1620/tjem.195.21
Among exocyclic DNA adducts, etheno (epsilon) bases (epsilond A, epsilond C, N(2),3-epsilond G) are generated by reactions of DNA bases with lipid peroxidation (LPO) products derived from endogenous sources and from the carcinogens vinyl chloride or urethane. The recent development of ultrasensitive methods has made it possible to detect these …
Indication of linkage and genetic heterogeneity of asthma according to age at onset on chromosome 7q in 107 French EGEA families
Publication Year: 2001 Source: Eur J Hum Genet PMID: 11781705 DOI: 10.1038/sj.ejhg.5200732
Caveolae are vesicular invaginations of the plasma membrane that act as a scaffold of the assembly of many classes of signaling molecules. Caveolins are the principal structural component of caveolae membranes, and three distinct forms of caveolins have been identified: caveolin-1, caveolin-2, and caveolin-3. In this study, we evaluated the …
IBD: how important are clinical epidemiological studies?
Publication Year: 2001 Source: Dig Liver Dis PMID: 11785708 DOI: 10.1016/s1590-8658(01)80039-6
Comment on Am J Gastroenterol. 2007 Apr;102(4):803-13.
Pooling data and linkage analysis in the chromosome 5q candidate region for asthma
Publication Year: 2001 Source: Genet Epidemiol PMID: 11793650 DOI: 10.1002/gepi.2001.21.s1.s103
BACKGROUND: In order to assess the usefulness of radiolabeled white cell scanning in the diagnosis of intestinal inflammation, subjects were asked to rank several dimensions of preference for white cell scanning in relation to other diagnostic tests. Two groups were surveyed: one known to have inflammatory bowel disease and the …
Meta-analysis of sib pair linkage studies of asthma and the interleukin-9 gene (IL9)
Publication Year: 2001 Source: Genet Epidemiol PMID: 11793651 DOI: 10.1002/gepi.2001.21.s1.s109
BACKGROUND & AIMS: Collagenous colitis (CC) is a well-described entity causing chronic diarrhea and characteristic histologic findings. Several treatment options have been suggested, but no controlled data are available. We conducted a placebo-controlled trial to show the clinical and histologic effects of budesonide in CC. METHODS: Twenty-eight patients were randomly …
Marker selection by Akaike information criterion and Bayesian information criterion
Publication Year: 2001 Source: Genet Epidemiol PMID: 11793681 DOI: 10.1002/gepi.2001.21.s1.s272
A multimarker linkage disequilibrium mapping method was developed for the fine mapping of quantitative trait loci (QTL) using a dense marker map. The method compares the expected covariances between haplotype effects given a postulated QTL position to the covariances that are found in the data. The expected covariances between the …
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