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Implication of TNF-alpha convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis
Publication Year: 2001 Source: Cytokine PMID: 11884025 DOI: 10.1006/cyto.2001.0969
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Psychiatric predictors of noncompliance in inflammatory bowel disease: psychiatry and compliance
Publication Year: 2001 Source: J Clin Gastroenterol PMID: 11154175 DOI: 10.1097/00004836-200101000-00015
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Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease
Publication Year: 2001 Source: Gut PMID: 11156637 DOI: 10.1136/gut.48.2.176
6-mercaptopurine (6-MP) and azathioprine (AZA) are used to treat inflammatory bowel disease (IBD). Side effects include infection, leukopenia, hepatitis, and pancreatitis. The level of thiopurine methyltransferase (TPMT), which metabolizes 6-MP to 6-methylmercaptopurine, may reflect the risk of side effects. We sought to evaluate the relationship between the side effects of …
Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease
Publication Year: 2001 Source: Gut PMID: 11156639 DOI: 10.1136/gut.48.2.191
The human GNAI2 gene coding for G protein, Galphai2, is located on chromosome 3p21 in proximity to the region where an inflammatory bowel disease (IBD) locus has been suggested. Galphai2-deficient mice develop a lethal diffuse colitis that resembles human ulcerative colitis (UC) and frequently progresses to colon adenocarcinoma. Furthermore, the …
Interferon-gamma and interleukin-10 reciprocally regulate endothelial junction integrity and barrier function
Publication Year: 2001 Source: Microvasc Res PMID: 11162203 DOI: 10.1006/mvre.2000.2288
BACKGROUND: Inflammatory bowel diseases (IBD) are characterised by an intense infiltration of leucocytes that is mediated by adhesion molecules expressed on the surface of activated endothelial cells. AIMS: To determine whether drugs used in the treatment of IBD, specifically dexamethasone (DEX), 5-aminosalicylic acid (5-ASA), methotrexate (MTX), and 6-mercaptopurine (6-MP), alter …
Patients with inflammatory bowel disease (IBD) reveal increased induction capacity of intracellular interferon-gamma (IFN-gamma) in peripheral CD8+ lymphocytes co-cultured with intestinal epithelial cells
Publication Year: 2001 Source: Clin Exp Immunol PMID: 11167992 DOI: 10.1046/j.1365-2249.2001.01443.x
BACKGROUND/AIMS: Studies concerning red cell distribution width (RDW) for use in the assessment of inflammatory bowel disease (IBD) activity are limited. We investigated whether RDW is a marker of active disease in patients with IBD. METHODS: In total, 61 patients with ulcerative colitis (UC) and 56 patients with Crohn's disease …
Giant cells in pyoderma gangrenosum
Publication Year: 2001 Source: J Cutan Pathol PMID: 11168758 DOI: 10.1034/j.1600-0560.2001.280206.x
Empirical efforts to prove or disprove an association between stress and the course of inflammatory bowel disease (IBD) have had inconsistent results. Direct study of mediators of stress-related physiological processes may clarify this important area. METHODS: candidate mediators were selected based on evidence that they have a role in the …
Melatonin reduces dinitrobenzene sulfonic acid-induced colitis
Publication Year: 2001 Source: J Pineal Res PMID: 11168901 DOI: 10.1034/j.1600-079x.2001.300101.x
Reactive oxygen metabolites (ROM) are increased in the inflamed mucosa of inflammatory bowel disease (IBD) and may contribute to loss of intestinal barrier function in this disorder. Growth factors (GF) are protective. But the mechanisms of disruption and protection remain elusive. In the present investigation, we hypothesized that the microtubules …
Enteric bacterial antigens activate CD4(+) T cells from scid mice with inflammatory bowel disease
Publication Year: 2001 Source: Eur J Immunol PMID: 11169434 DOI: 10.1002/1521-4141(200101)31:1<23::aid-immu23>3.0.co;2-2
OBJECTIVE: There is a perception of increasing and widespread use of alternative medicine for inflammatory bowel disease (IBD). We assessed the usage of alternative therapies among patients with IBD, whether there were similar or contrasting variables that were predictive of such use, and contrasted the use in four different centers …
Increased expression of IL-16 in inflammatory bowel disease
Publication Year: 2001 Source: Gut PMID: 11171821 DOI: 10.1136/gut.48.3.326
BACKGROUND AND AIM: Colonoscopic perforation is a rare complication. We sought to determine its risk factors in patients with inflammatory bowel disease (IBD). MATERIALS AND METHODS: The study group consisted of 19 IBD patients who had perforation secondary to diagnostic or therapeutic colonoscopy from January 2002 to October 2010. The …
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